A gene cluster for the mevalonate pathway from Streptomyces sp. Strain CL190

Journal of Bacteriology

Volumn 182, Issue 15, 2000, Pages 4153-4157

  Takagi, Motoki ^a   Kuzuyama, Tomohisa ^a   Takahashi, Shunji ^a,b   Seto, Haruo ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA; FOSMIDOMYCIN; GLYCOLIPID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; ISOPENTENYL DIPHOSPHATE; ISOPRENOID; ISOPROPYL BETA THIOGALACTOSIDE; MEVALONIC ACID; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CARBOHYDRATE SYNTHESIS; CONTROLLED STUDY; DNA FLANKING REGION; ESCHERICHIA COLI; GENE CLUSTER; GENE FUNCTION; GENE INDUCTION; GENE ISOLATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN FAMILY; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SPECIES DIFFERENCE; STRAIN DIFFERENCE; STREPTOMYCES;

ANTIGENS, BACTERIAL; ESCHERICHIA COLI; FOSFOMYCIN; HEMITERPENES; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA-REDUCTASES, NADP-DEPENDENT; ISOPROPYL THIOGALACTOSIDE; MAGNETIC RESONANCE SPECTROSCOPY; MEVALONIC ACID; MODELS, CHEMICAL; OPEN READING FRAMES; ORGANOPHOSPHORUS COMPOUNDS; SEQUENCE ANALYSIS, DNA; STREPTOMYCES;

EID: 0033942391     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.182.15.4153-4157.2000     Document Type: Article

References (39)

1. Armstrong, G. A., D. H. Burke, and J. E. Hearst. 1994. Functional assignment of Erwinia herbicola Eho10 carotenoid genes expressed in Escherichia coli. Mol. Gen. Genet. 245:406-416.
2. Bouvier, F., A. d'Harlingue, C. Suire, R. A. Backhous, and B. Camara. 1998. Dedicated roles of plastid transketolases during the early onset of isoprenoid biogenesis in pepper fruits. Plant Physiol. 117:1423-1431.
3. Bult, C. J., O. White, G. J. Olsen, L. Zhou, R. D. Fleischmann, G. G. Sutton, J. A. Blake, L. M. FitzGerald, R. A. Clayton, J. D. Gocayne, A. R. Kerlavage, M. A. Dougherty, J. F. Tomb, M. D. Adams, C. I. Reich, R. Overbeek, E. F. Kirkness, K. G. Weinstock, J. M. Merrick, A. Glodek, J. L. Scott, N. S. M. Geoghagen, and J. C. Venter. 1996. Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii. Science 273:1058-1073.
4. Dairi, T., Y. Motohira, T. Kuzuyama, S. Takahashi, N. Itoh, and H. Seto. 2000. Cloning of the gene encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase from terpenoid antibiotics-producing Streptomyces strains. Mol. Gen. Genet. 262:957-964.
5. Fraser, C. M., S. Casjens, W. M. Huang, G. G. Sutton, R. Clayton, R. Lathigra, O. White, K. A. Ketchum, R. Dodson, E. K. Hickey, M. Gwinn, B. Dougherty, J. F. Tomb, R. D. Fleischmann, D. Richardson, J. Peterson, A. R. Kerlavage, J. Quackenbush, S. Salzberg, M. Hanson, R. van Vugt, N. Palmer, M. D. Adams, J. Gocayne, J. C. Venter, et al. 1997. Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi. Nature 390: 580-586.
6. Funayama, S., M. Ishibashi, K. Komiyama, and S. Omura. 1990. Biosynthesis of furaquinocins A and B. J. Org. Chem. 55:1132-1133.
7. Horbach, S., H. Sahm, and R. Welle. 1993. Isoprenoid biosynthesis in bacteria: two different pathways? FEMS Microbiol. Lett. 111:135-140.
8. Ishikawa, J., and K. Hotta. 1999. FramePlot: a new implementation of the frame analysis for predicting protein-coding regions in bacterial DNA with a high G + C content. FEMS Microbiol. Lett. 174:251-253.
9. Isshiki, K., T. Tamamura, T. Sawa, H. Naganawa, T. Takeuchi, and H. Umezawa. 1986. Biosynthetic studies of terpentecin. J. Antibiot. 39:1634-1635.
10. Kawarabayasi, Y., M. Sawada, H. Horikawa, Y. Haikawa, Y. Hino, S. Yamamoto, M. Sekine, S. Baba, H. Kosugi, A. Hosoyama, Y. Nagai, M. Sakai, K. Ogura, R. Otsuka, H. Nakazawa, M. Takamiya, Y. Ohfuku, T. Funahashi, T. Tanaka, Y. Kudoh, J. Yamazaki, N. Kushida, A. Oguchi, K. Aoki, and H. Kikuchi. 1998. Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3. DNA Res. 5:55-76.
11. Klenk, H. P., R. A. Clayton, J. F. Tomb, O. White, K. E. Nelson, K. A. Ketchum, R. J. Dodson, M. Gwinn, E. K. Hickey, J. D. Peterson, D. L. Richardson, A. R. Kerlavage, D. E. Graham, N. C. Kyrpides, R. D. Fleischmann, J. Quackenbush, N. H. Lee, G. G. Sutton, S. Gill, E. F. Kirkness, B. A. Dougherty, K. McKenney, M. D. Adams, B. Loftus, J. C. Venter, et al. 1997. The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus. Nature 390:364-370.
12. Kuzuyama, T., M. Takagi, K. Kaneda, T. Dairi, and H. Seto. 2000. Formation of 4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol from 2-C-methyl-D-erythritol 4-phosphate by 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, a new enzyme in the nonmevalonate pathway. Tetrahedron Lett. 41:703-706.
13. Kuzuyama, T., M. Takagi, K. Kaneda, H. Watanabe, T. Dairi, and H. Seto. 2000. Studies on the nonmevalonate pathway: conversion of 4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol to its 2-phospho derivative by 4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol kinase. Tetrahedron Lett. 41: 2925-2928.
14. Kuzuyama, T., M. Takagi, S. Takahashi, and H. Seto. 2000. Cloning and characterization of 1-deoxy-D-xylulose 5-phosphate synthase from Streptomyces sp. strain CL190, which uses both the mevalonate and nonmevalonate pathways for isopentenyl diphosphate biosynthesis. J. Bacteriol. 182:891-897.
15. Kuzuyama, T., S. Takahashi, H. Watanabe, and H. Seto. 1998. Direct formation of 2-C-methyl-D-erythritol 4-phosphate from 1-deoxy-D-xylulose 5-phosphate by 1-deoxy-D-xylulose 5-phosphate reductoisomerase, a new enzyme in the non-mevalonate pathway to isopentenyl diphosphate. Tetrahedron Lett. 39:4509-4512.
16. Kuzuyama, T., S. Takahashi, and H. Seto. 1999. Construction and characterization of Escherichia coli disruptants defective in the yaeM gene. Biosci. Biotechnol. Biochem. 63:776-778.
17. Kuzuyama, T., T. Shimizu, S. Takahashi, and H. Seto. 1998. Fosmidomycin, a specific inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in the nonmevalonate pathway for terpenoid biosynthesis. Tetrahedron Lett. 39:7913-7916.
18. Lange, B. M., M. R. Wildung, D. McCaskill, and R. Croteau. 1998. A family of transketolases that directs isoprenoid biosynthesis via a mevalonate-independent pathway. Proc. Natl. Acad. Sci. USA 95:2100-2104.
19. Lipman, D. J., and W. R. Pearson. 1985. Rapid and sensitive similarity protein searches. Science 227:1435-1441.
20. Lois, L. M., N. Campos, S. R. Putra, K. Danielsen, M. Rohmer, and A. Boronat. 1998. Cloning and characterization of a gene from Escherichia coli encoding a transketolase-like enzyme that catalyzes the synthesis of D-1-deoxylylulose 5-phosphate, a common precursor for isoprenoid, thiamine, and pyridoxol biosynthesis. Proc. Natl. Acad. Sci. USA 95:2105-2110.
21. Lüttgen, H., F. Rohdich, S. Herz, J. Wungsintaweekul, S. Hecht, C. A. Schuhr, M. Fellermeier, S. Sagner, M. H. Zenk, A. Bacher, and E. Eisenreich. 2000. Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Proc. Natl. Acad. Sci. USA 97:1062-1067.
22. Montamat, F., M. Guilloton, F. Karst, S. Delrot. 1995. Isolation and characterization of a cDNA encoding Arabidopsis thaliana 3-hydroxy-3-methyl-glutaryl-coenzyme A synthase. Gene 167:197-201.
23. Pearson, W. R., and D. J. Lipman. 1988. Improved tools for biological sequence comparison. Proc. Natl. Acad. Sci. USA 85:2444-2448.
24. Putra, S. R., A. Disch, J. M. Bravo, and M. Rohmer. 1998. Distribution of mevalonate and glyceraldehyde 3-phosphate/pyruvate routes for isoprenoid biosynthesis in some gram-negative bacteria and mycobacteria. FEMS Microbiol. Lett. 164:169-175.
25. Riou, C., Y. Tourte, F. Lacroute, and F. Karst. 1994. Isolation and characterization of a cDNA encoding Arabidopsis thaliana mevalonate kinase by genetic complementation in yeast. Gene 148:293-297.
26. Rohdich, F., J. Wungsintaweekul, M. Fellermeier, S. Sagner, S. Herz, K. Kis, W. Eisenreich, A. Bacher, and M. H. Zenk. 1999. Cytidine 5′-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol. Proc. Natl. Acad. Sci. USA 96:11758-11763.
27. Rohmer, M. 1999. Isoprenoids including carotenoids and steroids, p. 45-67. In D. Barton and K. Nakanishi (ed.), Comprehensive natural products chemistry, vol. 2. Elsevier, Amsterdam, The Netherlands.
28. Sacchettini, J. C., and C. D. Poulter. 1997. Creating isoprenoid diversity. Science 277:1788-1789.
29. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
30. Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463-5467.
31. Seto, H., H. Watanabe, and K. Furihata. 1996. Simultaneous operation of the mevalonate and non-mevalonate pathways in the biosynthesis of isopentenyl diphosphate in Streptomyces aeriouvifer. Tetrahedron Lett. 37:7979-7982.
32. Shin-ya, K., K. Furihata, Y. Hayakawa, and H. Seto. 1990. Biosynthetic studies of naphterpin, a terpenoid metabolite of Streptomyces. Tetrahedron Lett. 31:6025-6026.
33. Shin-ya, K., S. Imai, K. Furihata, Y. Hayakawa, Y. Kato, G. D. Vanduyne, J. Clardy, and H. Seto. 1990. Isolation and structural elucidation of an antioxidative agent, naphterpin. J. Antibiot. 43:444-447.
34. Shiomi, K., H. Iinuma, H. Naganawa, K. Isshiki, T. Takeuchi, and H. Umezawa. 1987. Biosynthesis of napyradiomycins. J. Antibiot. 40:1740-1745.
35. Smith, D. R., L. A. Doucette-Stamm, C. Deloughery, H. Lee, J. Dubois, T. Aldredge, R. Bashirzadeh, D. Blakely, R. Cook, K. Gilbert, D. Harrison, L. Hoang, P. Keagle, W. Lumm, B. Pothier, D. Qiu, R. Spadafora, R. Vicaire, Y. Wang, J. Wierzbowski, R. Gibson, N. Jiwani, A. Caruso, D. Bush, H. Safer, D. Patwell, S. Prabhakar, S. McDougall, G. Shimer, A. Goyal, S. Pietrokovski, G. M. Church, C. J. Daniels, J.-I. Mao, P. Rice, J. Nölling, and J. N. Reeve. 1997. Complete genome sequence of Methanobacterium thermoautotrophicum ΔH: functional analysis and comparative genomics. J. Bacteriol. 179:7135-7155.
36. Sprenger, G. A., U. Schorken, T. Wiegert, S. Grolle, A. A. Graaf, S. V. Taylar, T. P. Begley, S. Bringer-Meyer, and H. Sahm. 1997. Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol. Proc. Natl. Acad. Sci. USA 94:12857-12862.
37. Takahashi, S., T. Kuzuyama, and H. Seto. 1999. Purification, characterization, and cloning of a eubacterial 3-hydroxy-3-methylglutaryl coenzyme A reductase, a key enzyme involved in biosynthesis of terpenoids. J. Bacteriol. 181:1256-1263.
38. Takahashi, S., T. Kuzuyama, H. Watanabe, and H. Seto. 1998. A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis. Proc. Natl. Acad. Sci. USA 95:9879-9884.
39. Toth, M. J., and L. Huwyler. 1996. Molecular cloning and expression of the cDNAs encoding human and yeast mevalonate pyrophosphate decarboxylase. J. Biol. Chem. 271:7895-7898.