Production of the carotenoids lycopene, β-carotene, and astaxanthin in the food yeast Candida utilis

Applied and Environmental Microbiology

Volumn 64, Issue 4, 1998, Pages 1226-1229

  Miura, Yutaka ^a   Kondo, Keiji ^a   Saito, Toshiko ^a   Shimada, Hiroshi ^a   Fraser, Paul D ^a,b   Misawa, Norihiko ^a  

^a KIRIN BREWERY CO LTD   (Japan)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ASTAXANTHIN; BETA CAROTENE; CAROTENOID; ERGOSTEROL; FUNGAL PROTEIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; LYCOPENE; RIBOSOME DNA;

ARTICLE; BIOSYNTHESIS; CANDIDA UTILIS; CONTROLLED STUDY; DIET SUPPLEMENTATION; FOOD SAFETY; FUNGUS GROWTH; GENE EXPRESSION; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PROMOTER REGION; YEAST;

AGROBACTERIUM AURANTIACUM; BACTERIA (MICROORGANISMS); CANDIDA; CANDIDA UTILIS; ERWINIA; ERWINIA UREDOVORA; FUNGI; PANTOEA ANANATIS; PICHIA JADINII; UNCULTURED MARINE BACTERIUM;

EID: 0031980175     PISSN: 00992240     EISSN: None     Source Type: Journal    
DOI: 10.1128/aem.64.4.1226-1229.1998     Document Type: Article

References (20)

1. Boze, H., G. Moulin, and P. Galzy. 1992. Production of food and fodder yeasts. Crit. Rev. Biotechnol. 12:65-86.
2. Giovannucci, E., A. Ascherio, E. B. Rimm, M. J. Stampfer, G. A. Colditz, and W. C. Willet. 1995. Intake of carotenoids and retinol in relation to risk of prostate cancer. J. Natl. Cancer Inst. 87:1767-1776.
3. Goodwin, T. W., and G. Britton. 1988. Distribution and analysis of carotenoids, p. 61-132. In T. W. Goodwin (ed.), Plant pigments. Academic Press, London, United Kingdom.
4. Ichii, T., S. Takenaka, H. Konno, T. Ishida, H. Sato, A. Suzuki, and K. Yamazumi. 1993. Development of a new commercial-scale airlift fermentor for rapid growth of yeast. J. Ferment. Bioeng. 75:375-379.
5. Johnson, E. A., and G.-H. An. 1991. Astaxanthin from microbial sources. Crit. Rev. Biotechnol. 11:297-326.
6. Jyocouchi, H., J. Hill, Y. Tomita, and R. A. Good. 1991. Studies of immunomodulating actions of carotenoids. I. Effects of β-carotene and astaxanthin on murine lymphocyte functions and cell surface marker expression in in vivo culture system. Nutr. Cancer 6:93-105.
7. Kondo, K. Unpublished data.
8. Kondo, K., S. Kajiwara, and N. Misawa. 1995. A transformation system for the yeast Candida utilis and the expression of heterologous genes therewith. Japanese patent application PCT/JP95/01005.
9. Kondo, K., Y. Miura, H. Sone, K. Kobayashi, and H. Iijima. 1997. High-level expression of a sweet protein, monellin, in the food yeast Candida utilis. Nature Biotechnol. 15:453-457.
10. Kondo, K., T. Saito, S. Kajiwara, M. Takagi, and N. Misawa. 1995. A transformation system for the yeast Candida utilis: use of a modified endogenous ribosomal protein gene as a drug-resistant marker and ribosomal DNA as an integration target for vector DNA. J. Bacteriol. 177:7171-7177.
11. Krinsky, N. I. 1989. Carotenoids in medicine, p. 279-291. In N. I. Krinsky, M. M. Mathews-Roth, and R. F. Taylor (ed.), Carotenoids. Chemistry and biochemistry. Plenum Press, New York, N.Y.
12. Miki, W. 1991. Biological functions and activities of animal carotenoids. Pure Appl. Chem. 63:141-146.
13. Misawa, N., M. Nakagawa, K. Kobayashi, S. Yamano, Y. Izawa, K. Nakamura, and K. Harashima. 1990. Elucidation of the Erwinia uredovora carotenoid biosynthetic pathway by functional analysis of gene products expressed in Escherichia coli. J. Bacteriol. 172:6704-6712.
14. Misawa, N., Y. Satomi, K. Kondo, A. Yokoyama, S. Kajiwara, T. Saito, T. Ohtani, and W. Miki. 1995. Structure and functional analysis of a marine bacterial carotenoid biosynthesis gene cluster and astaxanthin biosynthetic pathway proposed at the gene level. J. Bacteriol. 177:6575-6584.
15. Miura, Y., K. Kondo, H. Shimada, T. Saito, K. Nakamura, and N. Misawa. Production of lycopene by the food yeast, Candida utilis, that does not naturally synthesize carotenoid. Biotechnol. Bioeng., in press.
16. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
17. Shimada, H., Y. Miura, and N. Misawa. Unpublished data.
18. Wery, J., D. Gutker, A. C. H. M. Renniers, J. C. Verdoes, and A. J. J. Van Ooyen. 1997. High copy number integration into the ribosomal DNA of the yeast Phaffia rhodozyma. Gene 184:89-97.
19. Yamano, S., T. Ishii, M. Nakagawa, H. Ikenaga, and N. Misawa. 1994. Metabolic engineering for production of β-carotene and lycopene in Saccharomyces cerevisiae. Biosci. Biotechnol. Biochem. 58:1112-1114.
20. Yokoyama, A., H. Izumida, and W. Miki. 1994. Production of astaxanthin and 4-ketozeaxanthin by the marine bacterium, Agrobacterium aurantiacum. Biosci. Biotechnol. Biochem. 58:1842-1844.