3-hydroxy-3-methylglutaryl-CoA synthase intermediate complex observed in "real-time"

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 47, 2004, Pages 16442-16447

  Theisen, Michael J ^a   Misra, Ila ^b   Saadat, Dana ^b,d   Campobasso, Nino ^c   Miziorko, Henry M ^b,e   Harrison, David H T ^a  

^a ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c GLAXOSMITHKLINE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; ACETYL COENZYME A; CARBON; CYSTEINE; FATTY ACID; GLUTAMIC ACID; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; ISOPRENOID; METHYL GROUP; OXYGEN 18; POLYKETIDE; PROTEIN;

ARTICLE; CATALYSIS; COMPLEX FORMATION; CRYSTALLIZATION; DYNAMICS; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; POLYMERASE CHAIN REACTION; POLYMERIZATION; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS;

ACYL COENZYME A; BASE SEQUENCE; CATALYTIC DOMAIN; COENZYME A LIGASES; CRYSTALLOGRAPHY, X-RAY; DNA, BACTERIAL; ELECTROSTATICS; GENES, BACTERIAL; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; STAPHYLOCOCCUS AUREUS;

BACTERIA (MICROORGANISMS); POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 9344249564     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0405809101     Document Type: Article

References (27)

1. Greenspan, M. D., Yudkovitz, J. B., Lo, C. Y., Chen, J. S., Alberts, A. W., Hunt, V. M., Chang, M. N., Yang, S. S., Thompson, K. L., Chiang, Y. C., et al. (1987) Proc. Natl. Acad. Sci. USA 84, 7488-7492.
2. Too, K. K. & Burton, J. R. (2002) Drugs 62, 1707-1715.
3. Wilding, E. I., Brown, J. R., Bryant, A. P., Chalker, A. F., Holmes, D. J., Ingraham, K. A., Iordanescu, S., So, C. Y., Rosenberg, M. & Gwynn, M. N. (2000) J. Bacteriol. 182, 4319-4327.
4. Campobasso, N., Patel, M., Wilding, E. I., Kallender, H., Rosenberg, M. & Gwynn, M. (2004) J. Biol. Chem. 279, 44883-44888.
5. Edwards, D. J., Marquez, B. L., Nogle, L. M., McPhail, K., Goeger, D. E., Roberts, M. A. & Gerwick, W. H. (2004) Chem. Biol. 11, 817-833.
6. Miziorko, H. M. & Lane, M. D. (1977) J. Biol. Chem. 252, 1414-1420.
7. Miziorko, H. M., Clinkenbeard, K. D., Reed, W. D. & Lane, M. D. (1975) J. Biol. Chum. 250, 5768-5773.
8. Misra, I., Narasimhan, C. & Miziorko, H. M. (1993) J. Biol. Chem. 268, 12129-12135.
9. Chun, K. Y., Vinarov, D. A., Zajicek, J. & Miziorko, H. M. (2000) J. Biol. Chem. 275, 17946-17953.
10. Chun, K. Y., Vinarov, D. A. & Miziorko, H. M. (2000) Biochemistry 39, 14670-14681.
11. Schlichting, I., Berendzen, J., Phillips, G. N., Jr., & Sweet, R. M. (1994) Nature 371, 808-812.
12. Schlichting, I., Almo, S. C., Rapp, G., Wilson, K., Petratos, K., Lentfer, A., Wittinghofer, A., Kabsch, W., Pai, E. F., Petsko, G. A., et al. (1990) Nature 345, 309-315.
13. Stoddard, B. L., Bruhnkc, J., Koenigs, P., Porter, N., Ringe, D. & Petsko, G. A. (1990) Biochemistry 29, 8042-8051.
14. Otwinowski, Z. & Minor, W. (1997) Methods Enzymol. 276, 307-326.
15. Collaborative Computational Project No. 4 (1994) Acta Crystallogr. D 50, 760-763.
16. Brünger, A. T. (1992) Nature 355, 472-475.
17. Read, R. J. (2001) Acta Crystallogr. D 57, 1373-1382.
18. Jones,T. A., Zou, J. Y., Cowan, S. W. & Kjeldgaard, M. (1991) Acta Crystallogr. A 47, 110-119.
19. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., et al. (1998) Acta Crystallogr. D 54, 905-921.
20. Kraulis, P. J. (1991) J. Appl. Cryslallogr. 24, 946-950.
21. Fenn, T. (2003) J. Appl. Crystallogr. 36, 944-947.
22. Luzatti, P. V. (1952) Acta Crystallogr. A 5, 802-810.
23. Modis, Y. & Wierenga, R. K. (2000) J. Mol. Biol. 297, 1171-1182.
24. Qiu, X., Janson, C. A., Konstantinidis, A. K., Nwagwu, S., Silverman, C., Smith, W. W., Khandekar, S., Lonsdale, J. & Abdel-Meguid, S. S. (1999) J. Biol. Chem. 274, 36465-36471.
25. Davies, C., Heath, R. J., White, S. W. & Rock, C. O. (2000) Struct. Fold. Des. 8, 185-195.
26. Menahan, L. A., Hron, W. T., Hinkelman, D. G. & Miziorko, H. M. (1981) Eur. J. Biochem. 119, 287-294.
27. Agarwal, P. K., Billeter, S. R., Rajagopalan, P. T., Benkovic, S. J. & Hammes-Schiffer, S. (2002) Proc. Natl. Acad. Sci. USA 99, 2794-2799.