The catalytic cycle of biosynthetic thiolase: A conformational journey of an acetyl group through four binding modes and two oxyanion holes

Biochemistry

Volumn 41, Issue 52, 2002, Pages 15543-15556

  Kursula, Petri ^a   Ojala, Juha ^a   Lambeir, Anne Marie ^b   Wierenga, Rik K ^a  

^a UNIVERSITY OF OULU   (Finland)

^b UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CATALYSIS; CONDENSATION; CRYSTALLOGRAPHY; HORMONES; KETONES; NEGATIVE IONS;

SIDE CHAINS;

ENZYMES;

ACETYL COENZYME A ACETYLTRANSFERASE; KETONE BODY; NITROGEN; OXYGEN; STEROID HORMONE; THIOESTER;

ARTICLE; CATALYSIS; CHEMICAL MODIFICATION; CHEMICAL REACTION; CLAISEN CONDENSATION; CONFORMATIONAL TRANSITION; CRYSTALLOGRAPHY; ENZYME MECHANISM; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; ZOOGLOEA;

ACETYL-COA C-ACETYLTRANSFERASE; ACETYLATION; ACYL COENZYME A; ALANINE; ANIONS; BACTERIAL PROTEINS; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ENZYME INHIBITORS; GLUTAMINE; LIGANDS; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; ZOOGLOEA;

NEGIBACTERIA; ZOOGLOEA; ZOOGLOEA RAMIGERA;

EID: 0037207126     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0266232     Document Type: Article

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