Transfer of a protein binding epitope to a minimal designed peptide

Biopolymers - Peptide Science Section

Volumn 47, Issue 4, 1998, Pages 265-275

  Quan, C ^a   Skelton, N J ^a   Clark, K ^a   Jackson, D Y ^a   Renz, M E ^a   Chiu, H H ^a   Keating, S M ^a   Beresini, M H ^a   Fong, S ^a   Artis, D R ^a  

^a GENENTECH INC   (United States)

Author keywords

4 1, integrins; Antagonists, nmr spectroscopy; Epitope transfer; Peptides, receptor; Structure based design; Vascular Cell Adhesion Molecule

Indexed keywords

EPITOPE; INTEGRIN; OCTAPEPTIDE; VASCULAR CELL ADHESION MOLECULE 1;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CIRCULAR DICHROISM; CRYSTAL STRUCTURE; MOLECULAR MIMICRY; MOLECULAR MODEL; MUTAGENESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDE SYNTHESIS; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; BINDING, COMPETITIVE; EPITOPES; INTEGRIN ALPHA4BETA1; INTEGRINS; MAGNETIC RESONANCE SPECTROSCOPY; METHOTREXATE; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; PEPTIDES, CYCLIC; PROTEIN BINDING; RECEPTORS, LYMPHOCYTE HOMING; STRUCTURE-ACTIVITY RELATIONSHIP; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0000732512     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0282(1998)47:4<265::AID-BIP2>3.0.CO;2-K     Document Type: Article

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