Dynamics of trimethoprim bound to dihydrofolate reductase - A deuterium NMR study

Solid State Nuclear Magnetic Resonance

Volumn 7, Issue 3, 1996, Pages 193-201

  Yang, Qing Xian ^a,e   Huang, Fu Yung ^b   Lin, Ta Hsien ^b   Gelbaum, Leslie ^c   Howell, Elizabeth E ^d   Huang, Tai Huang ^a  

^a INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^d UNIVERSITY OF TENNESSEE   (United States)

^e PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Antifolate drug; Deuterium NMR; Dihydrofolate reductase; Protein dynamics; Trimethoprim

Indexed keywords

DEUTERIUM; DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRIMETHOPRIM;

ARTICLE; CHEMISTRY; ENZYMOLOGY; ESCHERICHIA COLI; METABOLISM; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CONFORMATION; THERMODYNAMICS;

DEUTERIUM; ESCHERICHIA COLI; FOLIC ACID ANTAGONISTS; MAGNETIC RESONANCE SPECTROSCOPY; NADP; PROTEIN CONFORMATION; TETRAHYDROFOLATE DEHYDROGENASE; THERMODYNAMICS; TRIMETHOPRIM;

BINARY MIXTURES; CHEMICAL BONDS; COMPUTER SIMULATION; DEUTERIUM; MACROMOLECULES; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLYCRYSTALLINE MATERIALS; POWDERS; RELAXATION PROCESSES;

ANTIFOLATE DRUG; DIHYDROFOLATE REDUCTASE; TRIMETHOPRIM;

PROTEINS;

EID: 0030300094     PISSN: 09262040     EISSN: None     Source Type: Journal    
DOI: 10.1016/0926-2040(95)01223-0     Document Type: Article

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