NMR solution structure of the antitumor compound PT523 and NADPH in the ternary complex with human dihydrofolate reductase

Biochemistry

Volumn 36, Issue 15, 1997, Pages 4399-4411

  Johnson, Jason M ^a   Meiering, Elizabeth M ^a,b   Wright, Joel E ^a   Pardo, Jorge ^a   Rosowsky, Andre ^a   Wagner, Gerhard ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF WATERLOO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; METHOTREXATE; NALPHA (4 AMINO 4 DEOXYPTEROYL) NDELTA HEMIPHTHALOYLORNITHINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; CONTROLLED STUDY; ENZYME CONFORMATION; ENZYME INHIBITOR INTERACTION; ENZYME SUBSTRATE COMPLEX; HUMAN; INHIBITION KINETICS; MOLECULAR INTERACTION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; FOLIC ACID ANTAGONISTS; HUMANS; KINETICS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; METHOTREXATE; NADP; ORNITHINE; PROTEIN CONFORMATION; PTERINS; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 0030936561     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi963039i     Document Type: Article

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