Characterization of rates of ring-flipping in trimethoprim in its ternary complexes with Lactobacillus casei dihydrofolate reductase and coenzyme analogues

Biochemistry

Volumn 38, Issue 48, 1999, Pages 15962-15969

  Polshakov, Vladimir I ^a,b   Birdsall, Berry ^b   Feeney, James ^b  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b Center for Drug Chemistry   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; NICOTINAMIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRIMETHOPRIM;

ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME STRUCTURE; LACTOBACILLUS CASEI; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; STRUCTURE ANALYSIS;

BINDING SITES; KINETICS; LACTOBACILLUS CASEI; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; NADP; TETRAHYDROFOLATE DEHYDROGENASE; THERMODYNAMICS; TRIMETHOPRIM;

EID: 0033619679     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9915263     Document Type: Article

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