Knowledge of the proposed chemical mechanism of action and cytochrome P450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides

Accounts of Chemical Research

Volumn 37, Issue 6, 2004, Pages 397-404

  Posner, Gary H ^a,b   O'Neill, Paul M ^c  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE; ALKYLATING AGENT; ANTIMALARIAL AGENT; ARTEMETHER; ARTEMISININ; ARTESUNATE; CARBONYL DERIVATIVE; CYTOCHROME P450; EPOXIDE; FERROUS ION; IRON; OXYGEN DERIVATIVE; PEROXIDE; PRODRUG; TRIOXANE DERIVATIVE; UNCLASSIFIED DRUG;

DRUG DESIGN; DRUG MECHANISM; DRUG METABOLISM; DRUG STRUCTURE; METABOLITE; REACTIVE INTERMEDIATE; REDUCTION; REVIEW;

ANIMALS; ANTIMALARIALS; ARTEMISININS; CYTOCHROME P-450 ENZYME SYSTEM; DRUG DESIGN; ELECTROCHEMISTRY; INDICATORS AND REAGENTS; PEROXIDES; SESQUITERPENES;

EID: 2942654745     PISSN: 00014842     EISSN: None     Source Type: Journal    
DOI: 10.1021/ar020227u     Document Type: Review

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