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Volumn 35, Issue 5, 2002, Pages 255-259

How might qinghaosu (artemisinin) and related compounds kill the intraerythrocytic malaria parasite? A chemist's view

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ARTEMISININ; ARTEMISININ DERIVATIVE; FREE RADICAL; SCAVENGER; SESQUITERPENE;

EID: 0036001107     PISSN: 00014842     EISSN: None     Source Type: Journal    
DOI: 10.1021/ar000080b     Document Type: Review
Times cited : (161)

References (45)
  • 1
    • 0002776039 scopus 로고    scopus 로고
    • How Chinese scientists discovered qinghaosu (artemisinin) and developed its derivatives? What are the future perspectives?
    • and the references therein
    • (1998) Med. Trop. , vol.58 , Issue.SUPPL. 3 , pp. 9-12
    • Li, Y.1    Wu, Y.-L.2
  • 2
    • 0021948029 scopus 로고
    • Qinghaosu (artemisinin): An antimalarial drug from China
    • (1985) Science , vol.228 , pp. 1049-1055
    • Klayman, D.L.1
  • 6
    • 0031002808 scopus 로고    scopus 로고
    • Time to put malaria control on the global agenda
    • (1997) Nature , vol.386 , pp. 535-536
    • Butler, D.1
  • 7
    • 0018612308 scopus 로고
    • Antimalarial studies on qinghaosu
    • (1979) Chin. Med. J. , vol.92 , pp. 811-816
  • 8
    • 0020097267 scopus 로고
    • Antimalarial efficacy and mode of action of qinghaosu and its derivatives in experimental models
    • Cf. also ref 1b above
    • (1982) J. Trad. Chin. Med. , vol.2 , pp. 17-24
  • 9
    • 0026746574 scopus 로고
    • A regiospecifically oxygen-18 labeled 1,2,4-trioxane: A simple chemical model to probe the mechanism(s) for the antimalarial activity of artemisinin (qinghaosu)
    • (1992) J. Am. Chem. Soc. , vol.114 , pp. 8328-8329
    • Posner, G.H.1    Oh, C.H.2
  • 17
    • 0033580871 scopus 로고    scopus 로고
    • Ring opening of artemisinin (qinghaosu) and dihydroartemisinin and interception of the open hydroperoxides with formation of N-oxides - A chemical model for antimalarial mode of action
    • (1999) Tetrahedron Lett. , vol.40 , pp. 4714-4718
    • Haynes, R.K.1    Pai, H.H.-O.2    Voerste, A.3
  • 33
    • 0035047259 scopus 로고    scopus 로고
    • New insights into the degradation of qinghaosu (artemisinin) mediated by non-heme iron chelates, and their relevance to the antimalarial mechanism
    • (2001) Helv. Chim. Acta , vol.84 , pp. 928-932
    • Wu, Y.-K.1    Yue, Z.-Y.2    Liu, H.-H.3
  • 35
    • 0031822599 scopus 로고    scopus 로고
    • Alkylating properties of antimalarial artemisinin derivatives and synthetic trioxanes when activated by a reduced heme model
    • (1998) Chem. Eur. J. , vol.4 , pp. 1287-1296
    • Robert, A.1    Meunier, B.2
  • 44
    • 0006202853 scopus 로고    scopus 로고
    • Reference 1b above and the original Chinese papers cited therein


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.