Biomimetic Fe(II)-mediated degradation of arteflene (Ro-42-1611). The first EPR spin-trapping evidence for the previously postulated secondary carbon-centered cyclohexyl radical

Journal of Organic Chemistry

Volumn 65, Issue 5, 2000, Pages 1578-1582

  O'Neill, Paul M ^a   Bishop, Laurence P D ^b   Searle, Natalie L ^a   Maggs, James L ^a   Storr, Richard C ^b   Ward, Stephen A ^a   Kevin Park, B ^a   Mabbs, Frank ^b  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEFLENE;

ANTIMALARIAL ACTIVITY; ARTICLE; DRUG ACTIVATION; DRUG DEGRADATION; ELECTRON SPIN RESONANCE; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

ALKYLATION; ANIMALS; ANTIMALARIALS; ARTEMISININS; BENZENESULFONATES; BICYCLO COMPOUNDS, HETEROCYCLIC; CYCLOHEXANES; DRUGS, CHINESE HERBAL; ELECTRON SPIN RESONANCE SPECTROSCOPY; FERROUS COMPOUNDS; FREE RADICALS; HEME; MAGNETIC RESONANCE SPECTROSCOPY; NITROSO COMPOUNDS; OXIDATION-REDUCTION; PLASMODIUM FALCIPARUM; SPIN LABELS; STYRENES;

EID: 0034629138     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo991585m     Document Type: Article

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