Antimalarial sulfone trioxanes

Tetrahedron Letters

Volumn 39, Issue 16, 1998, Pages 2273-2276

  Posner, Gary H ^a   O'Dowd, Hardwin ^a   Caferro, Thomas ^a   Cumming, Jared N ^a   Ploypradith, Poonsakdi ^a   Xie, Suji ^b   Shapiro, Theresa A ^b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,4 TRIOXANE DERIVATIVE; ANTIMALARIAL AGENT; ARTEMISININ; CHLOROQUINE;

ANTIMALARIAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

EID: 0032537147     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)00290-1     Document Type: Article

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32. 12. As a model system, monothioacetal i and its corresponding sulfoxide ii and sulfone iii were prepared. Their relative rates of ferrous, bromide-promoted hydrolysis in aqueous THF are ii ≫ i ≈ iii. Virtually no hydrolysis of sulfoxide ii occurred at r.t. for 1 h, however, in the absence of FeBr2. (equation presented)