Unified mechanistic framework for the Fe(II)-induced cleavage of Qinghaosu and derivatives/analogues. The first spin-trapping evidence for the previously postulated secondary C-4 radical

Journal of the American Chemical Society

Volumn 120, Issue 14, 1998, Pages 3316-3325

  Wu, Wen Min ^a   Wu, Yikang ^a   Wu, Yu Lin ^a   Yao, Zhu Jun ^a   Zhou, Cheng Ming ^a   Li, Ying ^b   Shan, Feng ^b  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMISININ; ARTEMISININ DERIVATIVE; ARTEMISININ EPOXIDE; RADICAL; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CHINESE MEDICINE; DERIVATIZATION; DNA CLEAVAGE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; SPIN TRAPPING; STRUCTURE ACTIVITY RELATION;

EID: 0032522115     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja973080o     Document Type: Article

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