Antigen-presentation and the role of dendritic cells in periodontitis

Periodontology 2000

Volumn 35, Issue , 2004, Pages 135-157

  Cutler, Christopher W ^a   Jotwani, Ravi ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; CYTOKINE;

ANTIGEN PRESENTATION; DENDRITIC CELL; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; PERIODONTITIS; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANTIGEN PRESENTATION; ANTIGENS, BACTERIAL; CYTOKINES; DENDRITIC CELLS; HUMANS; LYMPHOCYTE ACTIVATION; PERIODONTITIS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 2942628114     PISSN: 09066713     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0906-6713.2004.003560.x     Document Type: Review

References (203)

1. Agarwal S, Suzuki JB, Piesco NP, Aichelmann-Reidy MB. Neutrophil function in juvenile periodontitis: induction of adherence. Oral Microbiol Immunol 1994: 9: 262-271.
2. Akbari O, DeKruyff RH, Umetsu DT. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat Immunol 2001: 2: 725-731.
3. Alawi F, Stratton D, Freedman PD. Solitary fibrous tumor of the oral soft tissues: a clinicopathologic and immunohistochemical study of 16 cases. Am J Surg Pathol 2001: 25: 900-910.
4. Aloisi F, Ria F, Adorini L. Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes. Immunol Today 2000: 21: 141-147.
5. von Andrian UH, Mackay CR. T cell function and migration. Two sides of the same coin. N Engl J Med 2000: 343: 1020-1034.
6. Aoyagi T, Yamazaki K, Kabasawa-Katoh Y, Nakajima T, Yamashita T, Yoshie H, Hara K. Elevated CTLA-4 expression on CD4 T cells from periodontitis patients stimulated with Porphyromonas gingivalis outer membrane antigen. Clin Exp Immunol 2000: 119: 280-286.
7. Arpinati M, Green CL, Heimfeld S, Heuser JE, Anasetti C. Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells. Blood 2000: 95: 2484-2490.
8. Athanasas-Platsis S, Savage NW, Winning TA, Walsh LJ. Induction of the CD1a Langerhans cell marker on human monocytes. Arch Oral Biol 1995: 40: 157-160.
9. Azuma M, Cayabyab M, Buck D, Phillips JH, Lanier LL. Involvement of CD28 in MHC-unrestricted cytotoxicity mediated by a human natural killer leukemia cell line. J Immunol 1992: 149: 1115-1123.
10. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998: 392: 245-252.
11. Banchereau J, Briere F, Caux C, Davoust J, LeBecque S, Liu Y-J, Pulendran B, Palucka K. Immunobiology of dendritic cells. Annu Rev Immunol 2000: 18: 767-811.
12. Barrett AW, Raja AM. The immunohistochemical identification of human oral mucosal melanocytes. Arch Oral Biol 1997: 42: 77-81.
13. + T cells. Nature 1994: 372: 691-694.
14. Bielecki J, Youngman P, Connelly P, Portnoy DA. Bacillus subtilis expressing a haemolysin gene from Listeria monocytogenes can grow in mammalian cells. Nature 1990: 345: 175-176.
15. Biron CA, Nguyen KB, Pien GC, Cousens LP, Salazar-Mather. Natural killer cell in antiviral defense: function and regulation by innate cytokines. Annu Rev Immunol 1999: 17: 189-220.
16. Bondad-Palmario GG. Histological and immunochemical studies of oral leukoplakia: phenotype and distribution of immunocompetent cells. J Philipp Dent Assoc 1995: 47: 3-18.
17. Borkowski TA, Letterio JJ, Farr AG, Udey MC. A role for endogenous transforming growth factor β 1 in Langerhans cell biology: the skin of transforming growth factor β 1 null mice is devoid of epidermal Langerhans cells. J Exp Med 1996: 184: 2417-2422.
18. Bos JD, Kapsenberg ML. The skin immune system: progress in cutaneous biology. Immunol Today 1993: 14: 75-78.
19. + hematopoietic progenitors from human cord blood differentiate along two independent pathways in response to GM-CSF and TNF-α. J Exp Med 1996: 184: 695-706.
20. + hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to granulocyte-macrophage colony-stimulating factor plus tumor necrosis factor α: II. Functional analysis. Blood 1997: 90: 1458-1470.
21. Chambers CA, Salcedo M, Ljunggren HG. Triggering of natural killer cells by the costimulatory molecule CD80 (B7-1). Immunity 1996: 5: 311-317.
22. Chang CC, Ciubotariu R, Manavalan JS, Yuan J, Colovai AI, Piazza F, Lederman S, Colonna M, Cortesini R, Dalla-Favera R, Suciu-Foca N. Tolerization of dendritic cells by TS cells: the crucial role of inhibitory receptors ILT3 and ILT4. Nat Immunol 2002: 3: 237-243.
23. Chou LL, Epstein J, Cassol SA, West DM, He W, Firth JD. Oral mucosal Langerhans' cells as target, effector and vector in HIV infection. J Oral Pathol Med 2000: 29: 394-402.
24. Chrysomali E, Papanicolaou SI, Dekker NP, Regezi JA. Benign neural tumors of the oral cavity: a comparative immunohistochemical study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997: 84: 381-390.
25. Cirrincione C, Pimpinelli N, Orlando L, Romagnoli P. Lamina propria dendritic cells express activation markers and contact lymphocytes in chronic periodontitis. J Periodontol 2002: 73: 45-52.
26. Cutler CW, Jotwani R, Palucka KA, Davoust J, Bell D, Banchereau J. Evidence and a novel hypothesis for the role of dendritic cells and Porphyromonas gingivalis in adult periodontitis. J Periodontal Res 1999: 34: 406-412.
27. Cutler CW, Shindeling EA, Nunn M, Jotwani R, Kim BO, Nares S, Iacopino AM. Association between periodontitis and hyperlipidemia: cause or effect? J Periodontol 1999: 70: 1429-1434.
28. Cutler CW, Stanford TW, Abraham C, Cederberg RA, Boardman T, Ross C. Clinical benefits of oral irrigation for periodontitis are related to reduction of pro-inflammation cytokine levels and plaque. J Clin Periodontol 2000: 27: 134-143.
29. Cutler CW, Jotwani R, Pulendran B. Dendritic cells: Immune saviors or achilles' heel? Infect Immun 2001: 69: 4703-4708.
30. Dabelsteen E, Kirkeby S. ATP-ase positive cells in human oral mucosa transplanted to nude mice. Scand J Dent Res 1981: 89: 433-435.
31. Daniels TE. Human mucosal Langerhans cells: postmortem identification of regional variations in oral mucosa. J Invest Dermatol 1984: 82: 21-24.
32. Darji A, Chakraborty T, Wehland J, Weiss S. Listeriolysin generates a route for the presentation of exogenous antigens by major histocompatibility complex class I. Eur J Immunol 1995: 25: 2967-2971.
33. Darji A, Chakraborty T, Wehland J, Weiss S. TAP-dependent major histocompatibility complex class I presentation of soluble proteins using listeriolysin. Eur J Immunol 1997: 27: 1353-1359.
34. Daro E, Pulendran B, Brasel K, Teepe M, Pettit D, Lynch DH, Vremec D, Robb L, Shortman K, McKenna HJ, Maliszewski CR, Maraskovsky E. Polyethylene glycol modified GM-CSF expands CD11b (high) CD11c (high) but not CD11b (low) CD11c (high) murine dendritic cells in vivo: a comparative analysis with Flt3 ligand. J Immunol 2000: 165: 49-58.
35. Darveau RP, Tanner A, Page RC. The microbial challenge in periodontitis. Periodontol 2000 1997: 14: 12-32.
36. + T cells are poorly costimulated by ICAM-1. Eur J Immunol 1999: 29: 45-53.
37. Delves PJ, Roitt IM. The immune system. Second of two parts. N Engl J Med 2000: 343: 108-117.
38. Dietrich G, Hess J, Gentschev I, Knapp B, Kaufmann SH, Goebel W. From evil to good: a cytolysin in vaccine development. Trends Microbiol 2001: 9: 23-28.
39. Dieu-Nosjean MC, Massacrier C, Vanbervliet B, Fridman WH, Caux C. IL-10 induces CCR6 expression during Langerhans cell development while IL-4 and IFN-γ suppresses it. J Immunol 2001: 167: 5594-5602.
40. Dongari-Bagtzoglou AI, Ebersole JL. Increased presence of interleukin-6 (IL-6) and IL-8 secreting fibroblasts subpopulations in adult periodontitis. J Periodontol 1998: 69: 899-910.
41. Drakesmith H, Chain B, Beverly P. How can dendritic cells cause autoimmune disease? Immunol Today 2000: 21: 214-217.
42. + T cells. ICAM-1 or B7-1 can costimulate naive CD4 T cell activation but both are required for optimum response. J Immunol 1995: 155: 45-57.
43. El-Labban NG. The nature of Langerhans cells granules: an ultrastructural study. Histopathology 1982: 6: 317-325.
44. Engering AJ, Cella M, Fluitsma D, Brockhaus M, Hoefsmit EC, Lanzavecchia A, Pieters J. The mannose receptor functions as a high capacity and broad specificity antigen receptor in human dendritic cells. Eur J Immunol 1997: 27: 2417-2425.
45. Enk AH. Allergic contact dermatitis: understanding the immune response and potential for targeted therapy using cytokines. Mol Med Today 1997: 3: 423-428.
46. Facchetti F, de Wolf-Peeters C, van den Oord JJ, de Vos R, Desmet VJ. Plasmacytoid monocytes (so-called plasmacytoid T cells) in Kikuchi's lymphadenitis. An immunohistologic study. Am J Clin Pathol 1989: 92: 42-50.
47. Fairhurst RM, Wang CX, Sieling PA, Modlin RL, Braun J. CD1 presents antigens from a gram-negative bacterium, Haemophilus influenzae type B. Infect Immun 1998: 66: 3523-3526.
48. Fernandez NC, Lozier A, Flament C, Ricciardi-Castagnoli P, Bellet D, Suter M, Perricaudet M, Tursz T, Maraskovsky E, Zitvogel L. Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo. Nat Med 1999: 5: 405-411.
49. Figdor CG, van Kooyk Y, Adema GJ. C-type lectin receptors on dendritic cells and Langerhans cells. Nat Rev Immunol 2002: 2: 77-84.
50. Fiorentino DF, Bond MW, Mosmann TR. Two types of mouse helper T cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 1989: 170: 2081-2095.
51. Forster R, Schubel A, Breitfeld D, Kremmer E, Renner-Muller I, Wolf E, Lipp M. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 1999: 99: 23-33.
52. Foti M, Granucci F, Aggujaro D, Liboi E, Luini W, Minardi S, Mantovani A, Sozzani S, Ricciardi-Castagnoli P. Upon dendritic cell (dendritic cell) activation chemokines and chemokine receptor expression are rapidly regulated for recruitment and maintenance of dendritic cell at the inflammatory site. Int Immunol 1999: 11: 979-986.
53. de Fougerolles AR, Springer TA. Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function associated molecule on resting lymphocytes. J Exp Med 1992: 175: 185-190.
54. Freeman GJ, Gribben JG, Boussiotis VA, Ng JW, Restivo VA Jr, Lombard LA, Gray GS, Nadler LM. Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation. Science 1993: 262: 909-911.
55. Freeman GJ, Boussiotis VA, Anumanthan A, Bernstein GM, Ke XY, Rennert PD, Gray GS, Gribben JG, Nadler LM. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immunity 1995: 2: 523-532.
56. Freudenthal PS, Steinman RM. The distinct surface of human blood dendritic cells, as observed after an improved isolation method. Proc Natl Acad Sci USA 1990: 87: 7698-7702.
57. + progenitors. J Immunol 2000: 164: 3600-3607.
58. Geijtenbeek TB, Kwon DS, Torensma R, van Vliet SJ, van Duijnhoven GC, Middel J, Cornelissen IL, Nottet HS, KewalRamani VN, Littman DR, Figdor CG, van Kooyk Y. Dendritic cell-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell 2000: 100: 587-597.
59. Geissmann F, Prost C, Monnet JP, Dy M, Brousse N, Hermine O. Transforming growth factor β1, in the presence of granulocyte/macrophage colony-stimulating factor and interleukin 4, induces differentiation of human peripheral blood monocytes into dendritic Langerhans cells. J Exp Med 1998: 187: 961-966.
60. Geissmann F, Revy P, Regnault A, Lepelletier Y, Dy M, Brousse N, Amigorena S, Hermine O, Durandy A. TGF-β 1 prevents the noncognate maturation of human dendritic Langerhans cells. J Immunol 1999: 162: 4567-4575.
61. Gemmell E, Seymour G. Immunoregulatory control of Th1/Th2 cytokine profiles in periodontal disease. Periodontol 2000 2004: 35: 21-41.
62. Germain RN, Margulies DH. The biochemistry and cell biology of Ag processing and presentation. Annu Rev Immunol 1993: 11: 403-150.
63. Gestrelius S, Lyngstadaas SP, Hammarstrom L. Emdogain-periodontal regeneration based on biomimicry. Clin Oral Investig 2000: 4: 120-125.
64. Goebel VV, Kreft J. Cytolysins and the intracellular life of bacteria. Trends Microbiol 1997: 5: 86-88.
65. Gong J, Chen D, Kashiwaba M, Li Y, Chen L, Takeuchi H, Qu H, Rowse GJ, Gendler SJ, Kufe D. Reversal of tolerance to human MUC1 antigen in MUC1 transgenic mice immunized with fusions of dendritic and carcinoma cells. Proc Natl Acad Sci USA 1998: 95: 6279-6283.
66. Grabbe S, Schwarz T. Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity. Immunol Today 1998: 19: 37-44.
67. Granelli-Piperno A, Delgado E, Finkel V, Paxton W, Steinman RM. Immature dendritic cells selectively replicate M-tropic HIV-1, while mature cells efficiently transmit both M- and T-tropic virus to T cells. J Virol 1998: 72: 2733-2737.
68. Granucci F, Vizzardelli C, Pavelka N, Feau S, Persico M, Virzi E, Rescigno M, Moro G, Ricciardi-Castagnoli P. Inducible IL-2 production by dendritic cells revealed by global gene expression analysis. Nat Immunol 2001: 2: 882-888.
69. Greenstein G, Lamster I. Changing periodontal paradigms: therapeutic implications. Int J Periodontics Restorative Dent 2000: 20: 336-357.
70. Guerder S, Carding SR, Flavell RA. B7 costimulation is necessary for the activation of the lytic function in cytotoxic T lymphocyte precursors. J Immunol 1995: 155: 5167-5174.
71. Gumperz JE, Brenner MB. CD1-specific T cells in microbial immunity. Curr Opin Immunol 2001: 13: 471-478.
72. Gunhan M, Gunhan O, Celasun B, Azal O, Bostanci H. Gingival Langerhans' cells in type I diabetes mellitus. J Periodontol 1996: 67: 37-10.
73. Haque MF, Harris M, Meghji S, Speight PM. An immunohistochemical study of oral submucous fibrosis. J Oral Pathol Med 1997: 26: 75-82.
74. Hart DNJ. Dendritic cells: unique leukocyte populations, which control the primary immune response. Blood 1997: 90: 3245-3287.
75. Hasseus B, Jontell M, Bergenholtz G, Eklund C, Dahlgren UI. Langerhans cells from oral epithelium are more effective in stimulating allogeneic T-cells in vitro than Langerhans cells from skin epithelium. J Dent Res 1999: 78: 751-758.
76. Hathcock KS, Laszlo G, Pucillo C, Linsley P, Hodes RJ. Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function. J Exp Med 1994: 180: 631-640.
77. Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, Underhill DM, Aderem A. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 2001: 410: 1099-1103.
78. Heasman PA, Lauffart BL, Preshaw PM. Crevicular fluid prostaglandin E2 levels in periodontitis-resistant and periodontitis-susceptible adults. J Clin Periodontol 1998: 25: 1003-1007.
79. Hess J, Miko D, Catic A, Lehmensiek V, Russell DG, Kaufmann SH. Mycobacterium bovis Bacille Calmette-Guérin strains secreting listeriolysin of Listeria monocytogenes. Proc Natl Acad Sci USA 1998: 95: 5299-5304.
80. Hirschfeld M, Weis JJ, Toshchakov V, Salkowski CA, Cody MJ, Ward DC, Qureshi N, Michalek SM, Vogel SN. Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages. Infect Immun 2001: 69: 1477-1482.
81. Homey B, Dieu-Nosjean MC, Wiesenborn A, Massacrier C, Pin JJ, Oldham E, Catron D, Buchanan ME, Muller A, deWaal Malefyt R, Deng G, Orozco R, Ruzicka T, Lehmann P, Lebecque S, Caux C, Zlotnik A. Up-regulation of macrophage inflammatory protein-3 α/CCL20 and CC chemokine receptor 6 in psoriasis. J Immunol 2000: 164: 6621-6632.
82. Hussain LA, Lehner T. Comparative investigation of Langerhans' cells and potential receptors for HIV in oral genitourinary and rectal epithelia. Immunology 1995: 85: 475-484.
83. Ito H, Takekoshi T, Miyauchi M, Ogawa I, Takata T, Nikai H, Takemoto K. Three-dimensional appearance of Langerhans cells in human gingival epithelium as revealed by confocal laser scanning microscopy. Arch Oral Biol 1998: 43: 741-744.
84. Jiang W, Swiggard WJ, Heufler C, Peng M, Mirza A, Steinman RM, Nussenzweig MC. The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature 1995: 375: 151-155.
85. Jiang Y, Magli L, Russo M. Bacterium-dependent induction of cytokines in mononuclear cells and their pathologic consequences in vivo. Infect Immun 1999: 67: 2125-2130.
86. Jontell M, Okiji T, Dahlgren U, Bergenholtz G. Immune defense mechanisms of the dental pulp. Crit Rev Oral Biol Med 1998: 9: 179-200.
87. Jotwani R, Palucka AK, Al-Quotub M, Nouri-Shirazi M, Kim J, Bell D, Banchereau J, Cutler CW. Mature dendritic cells infiltrate the T cell-rich region of oral mucosa in chronic periodontitis: in situ, in vivo, and in vitro studies. J Immunol 2001: 167: 4693-4700.
88. Kaisho T, Akira S. Critical roles of Toll-like receptors in host defense. Crit Rev Immunol 2000: 20: 393-105.
89. Kalinski P, Hilkens CM, Wierenga EA, van der Pouw-Kraan TC, van Lier RA, Bos JD, Kapsenberg ML, Snijdewint FG. Functional maturation of human naive T helper cells in the absence of accessory cells. Generation of IL-4-producing T helper cells does not require exogenous IL-4. J Immunol 1995: 154: 3753-3760.
90. Kalinski P, Hilkens CM, Snijders A, Snijdewint FG, Kapsenberg ML. Dendritic cells, obtained from peripheral blood precursors in the presence of PGE2, promote Th2 responses. Adv Exp Med Biol 1997: 417: 363-367.
91. + dendritic cells: the levels of IL-12 are determined during the final dendritic cell maturation and are resistant to further modulation. J Immunol 1998: 161: 2804-2809.
92. Kalinski P, Lotze MT, Kapsenberg ML. Dendritic cell-related imunoregulation: signals and mediators. In: Lotze MT, Thomson AW, eds. Dendritic Cells, 2nd edn. San Diego: Academic Press, 2001: 51-74.
93. Karpinia K, Magnusson I. Recent approaches to periodontal therapy. Expert opinion on pharmacotherapy. Expert Opin Pharmacother 2000: 1: 1219-1226.
94. Kashihara M, Ueda M, Horiguchi Y, Furukawa F, Hanaoka M, Imamura S. A monoclonal antibody specifically reactive to human Langerhans cells. J Invest Dermatol 1986: 87: 602-607.
95. Katou F, Ohtani H, Saaristo A, Nagura H, Motegi K. Immunological activation of dermal Langerhans cells in contact with lymphocytes in a model of human inflamed skin. Am J Pathol 2000: 156: 519-527.
96. Katz SI, Tamaki K, Sachs DH. Epidermal Langerhans cells are derived from cells originating in bone marrow. Nature 1979: 282: 324-326.
97. Kawai T, Eisen-Lev R, Seki M, Eastcott JW, Wilson ME, Taubman MA. Requirement of B7 costimulation for Th1-mediated inflammatory bone resorption in experimental periodontal disease. J Immunol 2000: 164: 2102-2109.
98. van Kooten C, Banchereau J. CD40-CD40 ligand. J Leukoc Biol 2000: 67: 2-17.
99. Kosco-Vilbois MH. Follicular dendritic cells: molecules associated with function. In: Lotze MT, Thomson AW, eds. Dendritic Cells. Biology and Clinical Application, 2nd edn. San Diego: Academic Press, 2001: 29-34.
100. Krisanaprakornkit S, Kimball JR, Weinberg A, Darveau RP, Bainbridge BW, Dale BA. Inducible expression of human β-defensin 2 by Fusobacterium nucleatum in oral epithelial cells: multiple signaling pathways and role of commensal bacteria in innate immunity and the epithelial barrier. Infect Immun 2000: 68: 2907-2915.
101. Kropshofer H, Hammerling GJ, Vogt AB. The impact of the non-clasical MHC proteins HLA-DM and HLA-DO on loading of MHC class II molecules. Immunol Rev 1999: 172: 267-278.
102. Laine ML, van Winkelhoff AJ. Virulence of six capsular serotypes of Porphyromonas gingivalis in a mouse model. Oral Microbiol Immunol 1998: 13: 322-325.
103. Larsen CP, Steinman RM, Witmer-Pack M, Hankins DF, Morris PJ, Austyn JM. Migration and maturation of Langerhans cells in skin transplants and explants. J Exp Med 1990: 172: 1483-1493.
104. Larsson A, Warfvinge G. Immunohistochemistry of 'tertiary lymphoid follicles' in oral amalgam-associated lichenoid lesions. Oral Dis 1998: 4: 187-193.
105. Le Guiner S, Le Drean E, Labarriere N, Fonteneau JF, Viret C, Diez E, Jotereau F. LFA-3 co-stimulates cytokine secretion by cytotoxic T lymphocytes by providing a TCR-independent activation signal. Eur J Immunol 1998: 28: 1322-1331.
106. Le Naour F, Hohenkirk L, Grolleau A, Misek DE, Lescure P, Geiger JD, Hanash S, Beretta L. Profiling changes in gene expression during differentiation and maturation of monocyte-derived dendritic cells using both oligonucleotide microarrays and proteomics. J Biol Chem 2001: 276: 17920-17931.
107. Lenschow DJ, Walunas TL, Bluestone JA. CD28/B7 system of T cell costimulation. Annu Rev Immunol 1996: 14: 233-58.
108. Lombardi T, Hauser C, Budtz-Jorgensen E. Langerhans cells: structure, function and role in oral pathological conditions. J Oral Pathol Med 1993: 22: 193-202.
109. van Loon LA, van Elsas PW, Bos JD, ten Harkel-Hagenaar HC, Krieg SR, Davidson CL. T-lymphocyte and Langerhans cell distribution in normal and allergically induced oral mucosa in contact with nickel-containing dental alloys. J Oral Pathol 1988: 17: 129-137.
110. van Loon LA, Krieg SR, Davidson CL, Bos JD. Quantification and distribution of lymphocyte subsets and Langerhans cells in normal human oral mucosa and skin. J Oral Pathol Med 1989: 18: 197-201.
111. Lotze MT, Thomson AW, eds. Dendritic Cells. Biology and Clinical Application, 2nd edn. San Diego: Academic Press, 2001.
112. Luksch CR, Winqvist O, Ozaki ME, Karlsson L, Jackson MR, Peterson PA, Webb SR. Intercellular adhesion molecule-1 inhibits interleukin 4 production by naive T cells. Proc Natl Acad Sci USA 1999: 96: 3023-3028.
113. Lundqvist C, Hammarstrom ML. T-cell receptor γ δ-expressing intraepithelial lymphocytes are present in normal and chronically inflamed human gingiva. Immunology 1993: 79: 38-45.
114. MacDonald AS, Straw AD, Dalton NM, Pearce EJ. Cutting edge. Th2 response induction by dendritic cells: a role for CD40. J Immunol 2002: 168: 537-540.
115. Maraskovsky E, Brasel K, Teepe M, Roux ER, Lyman SD, Shortman K, McKenna HJ. Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified. J Exp Med 1996: 184: 1953-1962.
116. McAdam AJ, Schweitzer AN, Sharpe AH. The role of B7 costimulation in activation and differentiation of CD4 and CD8 T cells. Immunol Rev 1998: 165: 231-247.
117. McCartan BE, Lamey PJ. Expression of CD1 and HLA-DR by Langerhans cells (LC) in oral lichenoid drug eruptions (LDE) and idiopathic oral lichen planus (LP). J Oral Pathol Med 1997: 26: 176-180.
118. Mizukawa N, Sugiyama K, Yamachika E, Ueno T, Mishima K, Takagi S, Sugahara T. Presence of defensin in epithelial Langerhans cells adjacent to oral carcinomas and precancerous lesions. Anticancer Res 1999: 19 (4B): 2969-2971.
119. Mogi M, Otogoto J, Ota N, Inagaki H, Minami M, Kojima K. Interleukin I β, interleukin 6, β 2-microglobulin, and transforming growth factor-α in gingival crevicular fluid from human periodontal disease. Arch Oral Biol 1999: 44: 535-539.
120. Moody DB, Reinhold BB, Guy MR, Beckman EM, Frederique DE, Furlong ST, Ye S, Reinhold VN, Sieling PA, Modlin RL, Besra GS, Porcelli SA. Structural requirements for glycolipid antigen recognition by CD1b-restricted T cells. Science 1997: 278: 283-286.
121. Mostafa KA, Takata T, Ogawa I, Ijuhin N, Nikai H. Verruciform xanthoma of the oral mucosa: a clinicopathological study with immunohistochemical findings relating to pathogenesis. Virchows Arch A Pathol Anat Histopathol 1993: 423: 243-248.
122. Moughal NA, Adonogianaki E, Kinane DF. Langerhans cell dynamics in human gingiva during experimentally induced inflammation. J Biol Buccale 1992: 20: 163-167.
123. Myint M, Yuan ZN, Schenck K. Reduced numbers of Langerhans cells and increased HLA-DR expression in keratinocytes in the oral gingival epithelium of HIV-infected patients with periodontitis. J Clin Periodontol 2000: 27: 513-519.
124. Natah SS, Hayrinen-Immonen R, Hietanen J, Malmstrom M, Konttinen YT. Factor XIIIa-positive dendrocytes are increased in number and size in recurrent aphthous ulcers (RAU). J Oral Pathol Med 1997: 26: 408-413.
125. Nestle FO, Filgueira L, Nickoloff BJ, Burg G. Human dermal dendritic cells process and present soluble protein antigens. J Invest Dermatol 1998: 110: 762-766.
126. Newcomb GM, Seymour GJ, Powell RN. Association between plaque accumulation and Langerhans cell numbers in the oral epithelium of attached gingiva. J Clin Periodontol 1982: 9: 297-304.
127. Nichols FC, Levinbook H, Shnaydman M, Goldschmidt J. Prostaglandin E2 secretion from gingival fibroblasts treated with interleukin-1β: effects of lipid extracts from Porphyromonas gingivalis or calculus. J Periodontal Res 2001: 36: 142-152.
128. Okada H, Murakami S. Cytokine expression in periodontal health and disease. Crit Rev Oral Biol Med 1998: 9: 248-266.
129. O'Malley M, Pogrel MA, Stewart JC, Silva RG, Regezi JA. Central giant cell granulomas of the jaws: phenotype and proliferation-associated markers. J Oral Pathol Med 1997: 26: 159-163.
130. Palucka KA, Banchereau J. Dendritic cells: a link between innate and adaptive immunity. J Clin Immunol 1999: 19: 12-25.
131. + T cells. J Immunol 1997: 159: 591-598.
132. Paroli M, Schiaffella E, Di Rosa F, Barnaba V. Persisting viruses and autoimmunity. J Neuroimmunol 2000: 107: 201-204.
133. Pope M, Betjes MG, Romani N, Hirmand H, Cameron PU, Hoffman L, Gezelter S, Schuler G, Steinman RM. Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1. Cell 1994: 78: 389-398.
134. Porcelli SA. The CD1 family: a third lineage of antigen-presenting molecules. Adv Immunol 1995: 59: 1-98.
135. - T-lymphocytes to a microbial antigen. Nature 1992: 360: 593-597.
136. Portnoy DA, Chakraborty T, Goebel W, Cossart P. Molecular determinants of Listeria monocytogenes pathogenesis. Infect Immun 1992: 60: 1263-1267.
137. Pulendran B, Lingappa J, Kennedy MK, Smith J, Teepe M, Rudensky A, Maliszewski CR, Maraskovsky E. Developmental pathways of dendritic cells in vivo: distinct function, phenotype and localization of dendritic cell subsets in FLT3-ligand treated mice. J Immunol 1997: 159: 2222-2231.
138. Pulendran B, Smith JL, Caspary G, Brasel K, Pettit D, Maraskovsky E, Maliszewski CR. Distinct dendritic cell subsets differentially regulate the class of an immune response in vivo. Proc Natl Acad Sci USA 1999: 96: 1036-1041.
139. Pulendran B, Banchereau J, Burkeholder S, Kraus E, Guinet E, Chalouni C, Caron D, Maliszewski C, Davoust J, Fay J, Palucka K. Flt3-ligand and granulocyte-colony stimulating factor mobilize distinct human dendritic cell subsets in - vivo. J Immunol 2000: 165: 566-572.
140. Pulendran B, Banchereau J, Maraskovsky E, Maliszewski C. Modulating the immune response with dendritic cells and their growth factors. Trends Immunol 2001: 22: 41-47.
141. Pulendran B, Kumar P, Cutler CW, Mohamadzadeh M, Van Dyke T, Banchereau J. Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo. J Immunol 2001: 167: 5067-5076.
142. Qureshi MN, Barr CE, Hewlitt I, Boorstein R, Kong F, Bagasra O, Bobroski LE, Joshi B. Detection of HIV in oral mucosal cells. Oral Dis 1997: 3: S73-S78.
143. + dendritic cell populations in normal tissue and fibrovascular lesions. J Cutan Pathol 1992: 19: 398-406.
144. Regezi JA, Daniels TE, Saeb F, Nickoloff BJ. Increased submucosal factor XIIIa-positive dendrocytes in oral lichen planus. J Oral Pathol Med 1994: 23: 114-118.
145. Rescigno M, Granucci F, Citterio S, Foti M, Ricciardi-Castagnoli P. Coordinated events during bacterial-induced dendritic cell maturation. Immunol Today 1999: 20: 200-203.
146. Rescigno M, Granucci F, Ricciardi-Castagnoli P. Molecular events of bacterial-induced maturation of dendritic cells. J Clin Immunol 2000: 20: 161-166.
147. Rescigno M, Rittig M, Citterio S, Matyszak MK, Foti M, Granucci F, Martino M, Fascio U, Rovere P, Ricciardi-Castagnoli P. Interaction of dendritic cells with bacteria. In: Lotze MT, Thomson AW, eds. Dendritic Cells. Biology and Clinical Application, 2nd edn. San Diego: Academic Press, 2001: 403-419.
148. Romagnoli P, Pimpinelli N, Mori M, Reichart PA, Eversole LR, Ficarra G. Immunocompetent cell in oral candidiasis of HIV-infected patients: an immunohistochemical and electron microscopical study. Oral Dis 1997: 3: 99-105.
149. + α β T cell pool. J Immunol 1999: 162: 366-371.
150. Rothkotter HJ, Pabst R. Lymphocyte subsets in jejunal and ileal Peyer's patches of normal and gnotobiotic minipigs. Immunology 1989: 67: 103-108.
151. de Saint-Vis B, Fugier-Vivier I, Massacrier C, Gaillard C, Vanbervliet B, Ait-Yahia S, Banchereau J, Liu YJ, Lebecque S, Caux C. The cytokine profile expressed by human dendritic cells is dependent on cell subtype and mode of activation. J Immunol 1998: 160: 1666-1676.
152. Sallusto F, Cella M, Danieli C, Lanzavecchia A. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: down-regulation by cytokines and bacterial products. J Exp Med 1995: 182: 389-400.
153. Schnare M, Holt AC, Takeda K, Akira S, Medzhitov R. Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88. Curr Biol 2000: 10: 1139-1142.
154. +) cytotoxic T lymphocyte priming capacity upon activation by T helper cell-independent or -dependent stimuli. J Exp Med 2000: 192: 145-150.
155. Seguier S, Godeau G, Brousse N. Immunohistological and morphometric analysis of intra-epithelial lymphocytes and Langerhans cells in healthy and diseased human gingival tissues. Arch Oral Biol 2000: 45: 441-452.
156. Seguier S, Godeau G, Leborgne M, Pivert G, Brousse N. Quantitative morphological analysis of Langerhans cells in healthy and diseased human gingiva. Arch Oral Biol 2000: 45: 1073-1081.
157. Seymour GJ, Gemmell E. Cytokines in periodontal disease: where to from here? Acta Odontol Scand 2001: 59: 167-173.
158. Seymour GJ, Gemmell E, Reinhardt RA, Eastcott J, Taubman MA. Immunopathogenesis of chronic inflammatory periodontal disease: cellular and molecular mechanisms. J Periodontal Res 1993: 28: 478-486.
159. Sharpe AH, Freeman GJ. The B7-CD28 superfamily. Nat Rev Immunol 2002: 2: 116-126.
160. Sieling PA, Chatterjee D, Porcelli SA, Prigozy TI, Mazzaccaro RJ, Soriano T, Bloom BR, Brenner MB, Kronenberg M, Brennan PJ, et al. CD1-restricted T cell recognition of microbial lipoglycan antigens. Science 1995: 269: 227-230.
161. Sieling PA, Jullien D, Dahlem M, Tedder TF, Rea TH, Modlin RL, Porcelli SA. CD1 expression by dendritic cells in human leprosy lesions: correlation with effective host immunity. J Immunol 1999: 162: 1851-1858.
162. + T cells in the CD1-restricted repertoire: derivation of mycobacteria-reactive T cells from leprosy lesions. J Immunol 2000: 164: 4790-4796.
163. Sigal LJ, Crotty S, Andino R, Rock KL. Cytotoxic T-cell immunity to virus-infected non-hematopoietic cells requires presentation of exogenous antigen. Nature 1999: 398: 77-80.
164. Sloan-Lancaster J, Evavold BD, Allen PM. Induction of T-cell anergy by altered Tcell receptor ligand on live antigen-presenting cells. Nature 1993: 363: 156-159.
165. Sloberg K, Jonsson R, Jontell M. Assessment of Langerhans cells in oral lichen planus using monoclonal antibodies. J Oral Pathol 1984: 13: 516-524.
166. Sohoel DC, Johannessen AC, Kristoffersen T, Nilsen R. Expression of HLA class II antigens in marginal periodontitis of patients with Down's syndrome. Eur J Oral Sci 1995: 103: 207-213.
167. Sozzani S, Luini W, Borsatti A, Polentarutti N, Zhou D, Piemonti L, D'Amico G, Power CA, Wells TN, Gobbi M, Allavena P, Mantovani A. Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines. J Immunol 1997: 159: 1993-2000.
168. Sozzani S, Allavena P, Vecchi A, Mantovani A. Chemokines and dendritic cell traffic. J Clin Immunol 2000: 20: 151-160.
169. Steinsvoll S, Halstensen TS, Schenck K. Extensive expression of TGF-β1 in chronically-inflamed periodontal tissue. J Clin Periodontol 1999: 26: 366-373.
170. Stenger S, Mazzaccaro RJ, Uyemura K, Cho S, Barnes PF, Rosat JP, Sette A, Brenner MB, Porcelli SA, Bloom BR, Modlin RL. Differential effects of cytolytic T cell subsets on intracellular infection. Science 1997: 276: 1684-1687.
171. Stenger S, Hanson DA, Teitelbaum R, Dewan P, Niazi KR, Froelich CJ, Ganz T, Thoma-Uszynski S, Melian A, Bogdan C, Porcelli SA, Bloom BR, Krensky AM, Modlin RL. An antimicrobial activity of cytolytic T cells mediated by granulysin. Science 1998: 282: 121-125.
172. Stewart JC, Regezi JA, Lloyd RV, McClatchey KD. Immunohistochemical study of idiopathic histiocytosis of the mandible and maxilla. Oral Surg Oral Med Oral Pathol 1986: 61: 48-53.
173. Suresh M, Whitmire JK, Harrington LE, Larsen CP, Pearson TC, Altman JD, Ahmed R. Role of CD28-B7 interactions in generation and maintenance of CD8 T cell memory. J Immunol 2001: 167: 5565-5573.
174. Takahashi K, Takigawa M, Takashiba S, Nagai A, Miyamoto M, Kurihara H, Murayama Y. Role of cytokine in the induction of adhesion molecules on cultured human gingival fibroblasts. J Periodontol 1994: 65: 230-235.
175. Takeichi O, Haber J, Kawai T, Smith DJ, Moro I, Taubman MA. Cytokine profiles of T-lymphocytes from gingival tissues with pathological pocketing. J Dent Res 2000: 79: 1548-1555.
176. Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, Takeda K, Akira S. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 1999: 11: 443-451.
177. Thery C, Amigorena S. The cell biology of antigen presentation in dendritic cells. Curr Opin Immunol 2001: 13: 45-51.
178. Thomas R, Davis LS, Lipsky PE. Isolation and characterization of human peripheral blood dendritic cells. J Immunol 1993: 150: 821-834.
179. Thoma-Uszynski S, Kiertscher SM, Ochoa MT, Bouis DA, Norgard MV, Miyake K, Godowski PJ, Roth MD, Modlin RL. Activation of toll-like receptor 2 on human dendritic cells triggers induction of IL-12, but not IL-10. J Immunol 2000: 165: 3804-3810.
180. Underhill DM, Ozinsky A, Hajjar AM, Stevens A, Wilson CB, Bassetti M, Aderem A. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 1999: 401: 811-815.
181. Valladeau J, Ravel O, Dezutter-Dambuyant C, Moore K, Kleijmeer M, Liu Y, Duvert-Frances V, Vincent C, Schmitt D, Davoust J, Caux C, Lebecque S, Saeland S. Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity 2000: 12: 71-81.
182. Vetvicka V, Tlaskalova-Hogenova H, Stepankova R. Effects of microflora antigens on lymphocyte migration patterns in germfree and conventional rats. Folia Biol (Praha) 1983: 29: 412-418.
183. Viola A, Lanzavecchia A. T cell activation determined by T cell receptor number and tunable thresholds. Science 1996: 273: 104-106.
184. Walsh LJ, Seymour GJ, Powell RN. Modulation of class II (DR and DQ) antigen expression on gingival Langerhans cells in vitro by γ interferon and prostaglandin E2. J Oral Pathol 1986: 15: 347-351.
185. Walsh LJ, Seymour GJ, Savage NW. Oral mucosal Langerhans cells express DR and DQ antigens. J Dent Res 1986: 65: 390-393.
186. Walsh LJ, Lander PE, Seymour GJ, Powell RN. In vitro modulation of T6 expression on gingival Langerhans cells by interleukin-1 inhibitors and ETAF. J Dent Res 1987: 66: 766-769.
187. Walton LJ, Macey MG, Thornhill MH, Farthing PM. Intra-epithelial subpopulations of T lymphocytes and Langerhans cells in oral lichen planus. J Oral Pathol Med 1998: 27: 116-123.
188. + T cell clones from peripheral blood of a chronic adult periodontitis patient. Clin Exp Immunol 1998: 113: 105-110.
189. Weiskirch LM, Paterson Y. Listeria monocytogenes: a potent vaccine vector for neoplastic and infectious disease. Immunol Rev 1997: 158: 159-169.
190. Werts C, Tapping RI, Mathison JC, Chuang TH, Kravchenko V, Saint Girons I, Haake DA, Godowski PJ, Hayashi F, Ozinsky A, Underhill DM, Kirschning CJ, Wagner H, Aderem A, Tobias PS, Ulevitch RJ. Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism. Nat Immunol 2001: 2: 346-352.
191. Winning T, Gemmell E, Polak B, Savage NW, Seymour GJ, Walsh LJ. Expression of CD1a monocytes cultured with supernatants from periodontally diseased gingival epithelial cells. Oral Dis 1996: 2: 247-252.
192. Wolf PR, Ploegh HL. How MHC class II molecules acquire peptide cargo: biosynthesis and trafficking through the endocytic pathway. Annu Rev Cell Dev Biol 1995: 11: 267-306.
193. Wu SJ, Grouard-Vogel G, Sun W, Mascola JR, Brachtel E, Putvatana R, Louder MK, Filgueira L, Marovich MA, Wong HK, Blauvelt A, Murphy GS, Robb ML, Innes BL, Birx DL, Hayes CG, Frankel SS. Human skin Langerhans cells are targets of dengue virus infection. Nat Med 2000: 6: 816-820.
194. Yamamoto M, Fujihashi K, Hiroi T, McGhee JR, Van Dyke TE, Kiyono H. Molecular and cellular mechanisms for periodontal diseases: role of Th1 and Th2 type cytokines in induction of mucosal inflammation. J Periodontal Res 1997: 32: 115-119.
195. Yamazaki K, Nakajima T, Kubota Y, Gemmell E, Seymour GJ, Hara K. Cytokine messenger RNA expression in chronic inflammatory periodontal disease. Oral Microbiol Immunol 1997: 12: 281-287.
196. Yamazaki K, Ohsawa Y, Yoshie H. Elevated proportion of natural killer T cells in periodontitis lesions: a common feature of chronic inflammatory diseases. Am J Pathol 2001: 158: 1391-1398.
197. Yang D, Chertov O, Bykovskaia SN, Chen Q, Buffo MJ, Shogan J, Anderson M, Schroder JM, Wang JM, Howard OM, Oppenheim JJ. Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science 1999: 286: 525-528.
198. + T cell responses to infectious agents, tumors, transplants and vaccines. Adv Immunol 1999: 73: 1-77.
199. Yoshimura S, Bondeson J, Foxwell BM, Brennan FM, Feldmann M. Effective antigen-presentation by dendritic cells is NF-κB dependent: coordinate regulation of MHC, costimulatory molecules and cytokines. Int Immunol 2001: 13: 675-683.
200. + T lymphocytes by human blood dendritic cells in vitro. J Clin Invest 1992: 90: 229.
201. Yun PL, Decarlo AA, Collyer C, Hunter N. Hydrolysis of interleukin-12 by Porphyromonas gingivalis major cysteine proteinases may affect local γ interferon accumulation and the Th1 or Th2 T-cell phenotype in periodontitis. Infect Immun 2001: 69: 5650-5660.
202. Zabel U, Baeuerle PA. Purified human I κ B can rapidly dissociate the complex of the NF-κB transcription factor with its cognate DNA. Cell 1990: 61: 255-265.
203. Zeng Z, Castano AR, Segelke BW, Stura EA, Peterson PA, Wilson IA. Crystal structure of mouse CD1: an MHC-like fold with a large hydrophobic binding groove. Science 1997: 277 339-345.