Increased Presence of Interleukin-6 (IL-6) and IL-8 Secreting Fibroblast Subpopulations in Adult Periodontitis

Journal of Periodontology

Volumn 69, Issue 8, 1998, Pages 899-910

  Dongari Bagtzoglou, Anna I ^a   Ebersole, Jeffrey L ^b  

^a Howard Hughes Medical Institute   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

CD40; Cytokines; Fibroblasts; Periodontitis pathogenesis

Indexed keywords

AUTACOID; CD40 ANTIGEN; INTERLEUKIN 1; INTERLEUKIN 6; INTERLEUKIN 8; PROSTAGLANDIN E2; VIMENTIN;

ADULT; AGED; ARTICLE; CELL CULTURE; CELL LINEAGE; CHRONIC DISEASE; CONNECTIVE TISSUE; FIBROBLAST; FLUORESCENT ANTIBODY TECHNIQUE; GINGIVA; HUMAN; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PATHOLOGY; PERIODONTITIS; PHENOTYPE; SECRETION;

ADULT; AGED; ANTIGENS, CD40; CELL LINEAGE; CELLS, CULTURED; CHRONIC DISEASE; CONNECTIVE TISSUE; DINOPROSTONE; FIBROBLASTS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GINGIVA; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-1; INTERLEUKIN-6; INTERLEUKIN-8; MIDDLE AGED; PERIODONTITIS; PHENOTYPE; VIMENTIN;

EID: 0032133297     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.1998.69.8.899     Document Type: Article

References (65)

1. Schluger S, Yuodelis R, Page RC, Johnson RH. Periodontal Diseases. Philadelphia: Lea & Febiger; 1990:211-215.
2. Dzink JL, Tanner ACR, Haffajee AD, Socransky SS. Gram-negative species associated with active destructive periodontal lesions. J Clin Periodontol 1988;12:648-659.
3. Page RC. The role of inflammatory mediators in the pathogenesis of periodontal diseases. J Periodont Res 1991;26:230-242.
4. Birkedal-Hansen H. Role of cytokines and inflammatory mediators in tissue destruction. J Periodont Res 1993;28:500-510.
5. Dongari-Bagtzoglou AI, Ebersole JL. Production of inflammatory mediators and cytokines by human gingival fibroblasts following bacterial challenge. J Periodont Res 1996;31:90-98.
6. 2 synthesis in human gingival fibroblasts through a primary effect on circulating mononuclear cells. Infect Immun 1987;55:2148-2154.
7. Bartold PM, Haynes DR. Interleukin 6 production by human gingival fibroblasts. J Periodont Res 1991;26:339-345.
8. Hanazawa H, Hirosi K, Ohmori Y, Amano S, Kitano S. Bacteroides gingivalis fimbriae stimulate production of thymocyte activating factor by human gingival fibroblasts. Infect Immun 1988;56:272-274.
9. Tamura M, Takada H. Prevotella intermedia lipopolysaccharide induced IL-8 mRNA in human gingival fibroblast cultures. In: Hamada S, Holt SC, eds. Periodontal Disease: Pathogenesis & Host Immune Responses. Tokyo: Quintessence Publishing Co. Ltd.; 1991: 81.
10. Fries KM, Felch ME, Phipps RP. Interleukin 6 is an autocrine growth factor for murine lung fibroblast subsets. Am J Respir Cell Mol Biol 1994;11:552-560.
11. Mizel SB. Interleukin 1 and T-cell activation. Immunol Rev 1982; 63:51-72.
12. Stashenko P, Dewhirst FE, Peros WJ, Kent RL, Ago JE. Synergistic interactions between interleukin 1, tumor necrosis factor and lymphotoxin in bone resorption. J Immunol 1987;138:1464-1468.
13. Fries KM, Blieden T, Looney RJ, et al. Evidence of fibroblast heterogeneity and the role of fibroblast subpopulations in fibrosis. Clin Immunol Immunopathol 1994;72:283-292.
14. Feghali CA, Bost KL, Boulware DW, Levy LS. Mechanisms of pathogenesis in scleroderma. 1. Overproduction of IL-6 by fibroblasts cultured from affected skin sites of patients with scleroderma. J Rheumatol 1992;19:1207-1211.
15. Kawaguchi Y, Harigai M, Hara M, et al. Increased interleukin 1 receptor, type I, at messenger RNA and protein level in skin fibroblasts from patients with systemic sclerosis. Biochem Biophys Res Commun 1992;184:1504-1510.
16. Kawaguchi Y, Harigai M, Suzuki K, Hara M, et al. Interleukin 1 receptor on fibroblasts from systemic sclerosis patients induces excessive functional responses to interleukin 1 β. Biochem Biophys Res Commun 1993;190:154-161.
17. Breen E, Cutroneo KR. Biochemical and molecular aspects of pulmonary fibroblast heterogeneity. In: Phipps RP, ed. Pulmonary Fibroblast Heterogeneity. Boca Raton, FL: CRC Press, Inc; 1992:27-41.
18. Korn JH, Thrall RS, Willbur DC, Kream BE, Piela-Smith TH. Fibroblast heterogeneity: clonal selection of fibroblasts as a model for fibrotic disease. In: Phipps RP, ed. Pulmonary Fibroblast Heterogeneity. Boca Raton, FL: CRC Press, Inc; 1992:119-133.
19. Dongari-Bagtzoglou AI, Ebersole JL. Gingival fibroblast cytokine profiles in Actinobacillus actinomycetemcomitans-associated periodontitis. J Periodontol 1996;67:871-878.
20. Bird BR, Forrester FT. Basic Laboratory Techniques in Cell Culture. Atlanta: U.S. Department of Health and Human Services; 1981:81-92.
21. Irwin CR, Schor SL, Ferguson MWJ. Effects of cytokines on gingival fibroblasts in vitro are modulated by the extracellular matrix. J Periodont Res 1994;29:309-317.
22. Dongari-Bagtzoglou AI, Ebersole JL. Application of immunoprinting for assessment of fibroblast secretory heterogeneity. J Immunol Meth 1996;198:145-154.
23. Fries KM, Sempowski GD, Gaspari AA, Blieden T, Looney RJ, Phipps RP. CD40 expression by human fibroblasts. Clin Immunol Immunopathol 1995;77:42-51.
24. Yellin MJ, Winikoff S, Fortune SM, et al. Ligation of CD40 on fibroblasts induces CD54 (ICAM-1) and CD106 (VCAM-1) up-regulation and IL-6 production and proliferation. J Leuk Biol 1995; 58:209-216.
25. Stamenkovic I, Clark EA, Seed B. A B lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas. EMBO J 1989;8:1403-1410.
26. Yu X, Graves DT. Fibroblasts, mononuclear phagocytes, and endothelial cells express monocyte chemoattractant protein-1 (MCP-1) in inflamed human gingiva. J Periodontol 1995;66:80-88.
27. Gown A, Tsokada T, Ross R. Human atherosclerosis II. Immunohistochemical analysis of the cellular composition of human atherosclerotic lesions. Am J Pathol 1986;125:191-196.
28. Elias JA, Zitnik RJ, Ray P. Fibroblast immune-effector function. In: Phipps RP, ed. Pulmonary Fibroblast Heterogeneity. Boca Raton, FL: CRC Press, Inc; 1992:295-322.
29. Lotz M, Jink F, Kabouridis R, et al. B cell stimulation factor 2/interleukin-6 is a costimulant for human thymocytes and T lymphocytes. J Exp Med 1988;167:1253-1258.
30. Belch J. The role of eicosanoids in inflammation. In: Goodacre JA, Carson Dick W, eds. Immunopathogenetic Mechanisms of Arthritis. Lancaster, U.K.: MTP Press Ltd; 1988:26-50.
31. Pang G, Couch L, Baten R, Clancy R, Cripps A. GM-CSF, IL-1α, IL-1β, IL-6, IL-8, IL-10, ICAM-1 and VCAM-1 gene expression and cytokine production in human duodenal fibroblasts stimulated with lipopolysaccharide, IL-1α and TNFα. Clin Exp Immunol 1994; 96:437-443.
32. Elias JA, Reynolds MM, Kotloff RM, Kern JA. Fibroblast interleukin 1β: synergistic stimulation by recombinant interleukin 1 and tumor necrosis factor and posttranscriptional regulation. Proc Natl Acad Sci (USA) 1989;86:6171-6175.
33. Kostura MJ, Tocci MJ, Limjuco G, et al. Identification of a monocyte-specific pre-IL-1β convertase activity. Proc Natl Acad Sci (USA) 1989;86:5227-5235.
34. Di Giovine FS, Symons JA, Manson J, Duff GW. Soluble mediators of immunity. In: Immunopathogenetic Mechanisms of Arthritis. Goodacre JA, Carson Dick W, eds. Lancaster: MTP Press Ltd; 1988: 101-121.
35. Honing J, Rordorf AC, Seigmund C, Wiedermann W, Erard K. Increased IL-1β concentration in gingival tissues of periodontitis patients. J Periodont Res 1989;24:362-367.
36. Girgis RE, Basha MA, Mariarik M, Popovich J, Iannuzzi MC. Cytokines in the bronchoalveolar lavage fluid of patients with active pulmonary sarcoidosis. Am J Respir Crit Care Med 1995;152:71-75.
37. Mundy GR. Inflammatory mediators and the destruction of bone. J Periodont Res 1991;26:213-217.
38. Poli V, Balena R, Fattori E, et al. Interleukin 6-deficient mice are protected from bone loss caused by estrogen depletion. EMBO J 1994;13:1189-1196.
39. Sticherling M, Herzel F, Schroder J, Christophers E. Time- and stimulus-dependent secretion of NAP-1/IL-8 by human fibroblasts and endothelial cells. J Invest Dermatol 1993;101:573-576.
40. Takahashi K, Takashiba S, Nagai A, et al. Assessment of interleukin-6 in the pathogenesis of periodontal disease. J Periodontol 1994;65: 147-153.
41. Reinhardt RA, Masada MP, Kaldahl WB. Gingival crevicular fluid IL-1 and IL-6 levels in refractory periodontitis. J Clin Periodontol 1993;20:225-231.
42. Ko D, Page RC, Narayanan AS. Fibroblast heterogeneity and prostaglandin regulation of subpopulations. Proc Natl Acad Sci (USA) 1977;74:3429-3432.
43. Phipps RP, Baecher C, Frelinger JG, Penney DP, Keng P, Brown D. Differential expression of interleukin 1α by Thy-1 + and Thy-1 - lung fibroblast subpopulations: enhancement of Interleukin 1α production by TNFα. Eur J Immunol 1990;20:1723-1727.
44. 2 synthetic capacity of substrains are not stimulus-restricted. Arthr Rheum 1985; 28:315-322.
45. Korn JH. Clonal heterogeneity in the fibroblast response to mononuclear cell derived mediators. Arthr Rheum 1984;27:174-179.
46. Borello MA, Phipps RP. Differential Thy-1 expression by splenic fibroblasts defines functionally distinct subsets. Cell Immunol 1996; 173:198-203.
47. Holt PG, Plozza TM. Enumeration of antibody-secreting cells by immunoprinting: sequential readout of different antibody isotypes on individual cell monolayers employing the ELISA plaque assay. J Immunol Meth 1986;93:167-169.
48. Kahari VM, Sandberg M, Vuorio T, Vuorio E. Identification of fibroblasts responsible for increased collagen production in localized scleroderma by in situ hybridization. J Invest Dermatol 1988;90: 664-670.
49. Benditt EP, Benditt JM. Evidence for a monoclonal origin of human atherosclerotic plaques. Proc Natl Acad Sci (USA) 1973;70:1753-1756.
50. Narayanan AS, Raghu G. Phenotypic markers for pulmonary fibroblast subtypes. In: Phipps RP, ed. Pulmonary Fibroblast Heterogeneity. Boca Raton, FL: CRC Press, Inc; 1992:252-270.
51. Dongari-Bagtzoglou AI, Warren WD, Berton MT, Ebersole JL. CD40 expression by gingival fibroblasts: correlation of phenotype with function. Int Immunol 1997;9:1233-1241.
52. Alderson MR, Armitage RJ, Tough TW, Strockbine L, Fanslow WC, Spriggs MK. CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40. J Exp Med 1993;178:669-674.
53. Hess S, Rensing-Ehl A, Schwabe R, Butler P, Engelmann H. CD40 function in non-hematopoietic cells. Nuclear factor kB mobilization and induction of IL-6 production. J Immunol 1995;155:4588-4595.
54. Clark EA, Shu G. Association between IL-6 and CD40 signaling. IL-6 induces phosphorylation of CD40 receptors. J Immunol 1990; 145:1400-1406.
55. Gerritse K, Laman RJ, Noelle, Aruffo A, et al. CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis. Proc Natl Acad Sci (USA) 1996;93:2499-2504.
56. Ranheim EA, Kipps TJ. Elevated expression of CD80 (B7/BB1) and other accessory molecules on synovial fluid mononuclear cell subsets in rheumatoid arthritis. Arthr Rheum 1994;37:1637-1646.
57. Hollenbaugh D, Mischel-Petty N, Edwards CP, et al. Expression of functional CD40 by vascular endothelial cells. J Exp Med 1995;182: 33-40.
58. Potocnik AJ, Kinne R, Menninger H, Zacher J, Emmrich F, Kroczek RA. Expression of activation antigens on T cells in rheumatoid arthritis patients. Scand J Immunol 1990;31:213-224.
59. Sempowski GD, Chess PR, Moretti AJ, Padilla J, Phipps RP, Blieden TM. CD40 mediated activation of gingival and periodontal ligament fibroblasts. J Periodontol 1997;68:284-292.
60. Wilson TG, Kornman KS. Fundamentals of Periodontics. Carol Stream, IL; Quintessence Publishing Co; 1996:81-82.
61. Larsen CG, Anderson AO, Apella E, Openheim JJ, Matsusima K. Neutrophil-activating protein (NAP-1) is also chemotactic for T lymphocytes. Science 1989;243:1464-1467.
62. Armitage RJ, Fanslow WC, Strockbine L, et al. Molecular and biological characterization of a murine ligand for CD40. Nature 1992; 357:80-83.
63. Schroeder HE, Page RC. Lymphocyte-fibroblast interaction in the pathogenesis of inflammatory gingival disease. Experientia 1972;28: 1228-1230.
64. Murakami S, Shimabukuro Y, Teruyuki S, et al. Immunoregulatory roles of adhesive interactions between lymphocytes and gingival fibroblasts. In: Genco RJ, Mergenhagen SE, eds. Host-Parasite Interactions in Periodontal Diseases. Washington, DC: American Society for Microbiology; 1982:157.
65. Baggiolini M, Walz A, Kunkel SL. Neutrophil-activating peptide-1/interleukin-8: A novel cytokine that activates neutrophils. J Clin Invest 1989;84:1045-1049.