Inflammatory Cytokines Enhance the in Vivo Clonal Expansion and Differentiation of Antigen-Activated CD4+ T Cells

Journal of Immunology

Volumn 159, Issue 2, 1997, Pages 591-598

  Pape, Kathryn A ^a   Khoruts, Alexander ^a   Mondino, Anna ^a   Jenkins, Marc K ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; LIPOPOLYSACCHARIDE;

ADOPTIVE TRANSFER; ANIMAL; ANTIGEN PRESENTATION; ARTICLE; CD4+ T LYMPHOCYTE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MOUSE; TRANSGENIC MOUSE;

ADOPTIVE TRANSFER; ANIMALS; ANTIGEN PRESENTATION; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC;

EID: 0031570928     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Chan, A. C., D. M. Desai, and A. Weiss. 1994. The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction. Annu. Rev. Immunol. 12:555.
2. Lenschow, D. J., T. L. Walunas, and J. A. Bluestone. 1996. CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14:233.
3. Dresser, D. W. 1961. Effectiveness of lipid and lipidophilic substances as adjuvants. Nature 191:1169.
4. Freund, J., J. Casals, and E. P. Hosmer. 1937. Sensitization and antibody formation after injection of tubercle bacilli and paraffin oil. Proc. Soc. Exp. Biol. Med. 37:509.
5. Kyburz, D., P. Aichele, D. E. Speiser, H. Hengartner, R. M. Zinkernagel, and H. Pircher. 1993. T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides. Eur. J. Immunol 23:1956.
6. Warren, H. S., F. R. Vogel, and L. A. Chedid. 1986. Current status of immunological adjuvants. Annu. Rev. Immunol. 4:369.
7. Liu, Y., and C. A. Janeway, Jr. 1991. Microbial induction of co-stimulatory activity for CD4 T-cell growth. Int. Immunol. 3:323.
8. Alving, C. R. 1993. Lipopolysaccharide, Lipid A, and liposomes containing lipid A as immunologic adjuvants. Immunobiology 187:430.
9. lo thymocytes in vivo. Science 250: 1720.
10. Kearney, E. R., K. A. Pape, D. Y. Loh, and M. K. Jenkins. 1994. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity 1:327.
11. Haskins, K., R. Kubo, J. White, M. Pigeon, J. Kappler, and P. Marrack. 1983. The MHC-restricted antigen receptor on T cells. I. Isolation of a monoclonal antibody. J. Exp. Med. 157:1149.
12. Openshaw, P., E. E. Murphy, N. A. Hosken, V. Maino, K. Davis, K. Murphy, and A. O'Garra. 1995. Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J. Exp. Med. 182: 1357.
13. + T cells. J. Immunol. 154:4195.
14. Brouckaert, P., C. Libert, B. Everaerdt, N. Takahashi, A. Cauwels, and W. Fiers. 1993. Tumor necrosis factor, its receptors and the connection with interleukin 1 and interleukin 6. Immunobiology 187:317.
15. Paul, W. E., and R. A. Seder. 1994. Lymphocyte responses and cytokines. Cell 76:241.
16. Trinchieri, G. 1995. IL-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251.
17. Wolf, S. F., D. Sieburth, and J. Sypek. 1994. Interleukin 12: a key modulator of immune function. Stem Cells 12:154.
18. Skeen, M. J., M. A. Miller, T. M. Shinnick, and H. K. Ziegler. 1996. Regulation of murine macrophage IL-12 production. J. Immunol. 156:1196.
19. Wysocka, M., M. Kubin, L. Q. Vieira, L. Ozmen, G. Garotta, P. Scott, and G. Trinchieri. 1995. Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice. Eur. J. Immunol. 25: 672.
20. Parks, D. E., S. M. Walker, and W. Weigle. 1981. Bacterial lipopolysaccharide (endotoxin) interferes with the induction of tolerance and primes thymus-derived lymphocytes. J. Immunol. 126:938.
21. Vella, A. T., J. E. McCormack, P. S. Linsley, J. W. Kappler, and P. Marrack. 1995. Lipopolysaccharide interferes with the induction of peripheral T cell death. Immunity 2:261.
22. Pasparakis, M., L. Alexopoulou, V. Episkopou, and G. Kollias. 1996. Immune and inflammatory responses in TNF-α deficient mice: a critical requirement for TNF-α in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J. Exp. Med. 184:1397.
23. Weigle, W. O., W. V. Scheuer, M. V. Hobbs, E. L. Morgan, and D. E. Parks. 1987. Modulation of the induction and circumvention of immunological tolerance to human γ-globulin by interleukin 1. J. Immunol. 138:2069.
24. Reed, S. G., D. L. Pihl, P. J. Conlon, and K. H. Grabstein. 1989. Role of T cells in the augmentation of specific antibody production by recombinant human IL-1α. J. Immunol. 142:3129.
25. Nohria, A., and R. Rubin. 1994. Cytokines as potential vaccine adjuvants. Biotherapy 7:261.
26. Weaver, C. T., C. M. Hawrylowicz, and E. R. Unanue. 1988. T helper subsets require the expression of distinct costimulatory signals by antigen-presenting cells. Proc. Natl. Acad. Sci. USA 85:8181.
27. Dinarello, C. A. 1988. Biology of interleukin 1. FASEB J. 2:108.
28. Kurt-Jones, E. A., S. Hamberg, J. Ohara, W. E. Paul, and A. K. Abbas. 1987. Heterogeneity of helper/inducer T lymphocytes. I. Lymphokine production and lymphokine response. J. Exp. Med. 166:1774.
29. Lenschow, D. J., C. H.-T. Su, L. A. Zuckerman, N. Nabavi, C. L. Jellis, G. S. Gray, J. Miller, and J. A. Bluestone. 1993. Expression and functional significance of an additional ligand for CTLA-4. Proc. Natl. Acad. Sci. USA 90: 11054.
30. DeSmedt, T., B. Pajak, E. Muraille, L. Lespagnard, E. Heinen, P. D. Baetselier, J. Urbain, O. Leo, and M. Moser. 1996. Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo. J. Exp. Med. 184:1413.
31. McLellan, A. D., R. V. Sorg, L. A. Williams, and D. N. J. Hart. 1996. Human dendritic cells activate T lymphocytes via a CD40:CD40 ligand-dependent pathway. Eur. J. Immunol. 26:1204.
32. Inaba, K., M. Witmer-Pack, M. Inaba, K. S. Hathcock, H. Sakuta, M. Azuma, H. Yagita, K. Okumura, P. S. Linsley, S. Ikehara, S. Muramatsu, R. J. Hodes, and R. M. Steinman. 1994. The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro. J. Exp. Med. 180:1849.
33. Grewal, I. S., J. Xu, and R. A. Flavell. 1995. Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand. Nature 378:617.
34. Grewal, I. S., H. G. Foellmer, K. D. Grewal, J. Xu, F. Hardardottir, J. L. Baron, C. A. Janeway, Jr, and R. A. Flavell. 1996. Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis. Science 273:1864.
35. Yang, Y., and J. M. Wilson. 1996. CD40 ligand-dependent T cell activation: requirement of B7-CD28 signaling through CD40. Science 273:1862.
36. Forster, R., A. E. Mattis, E. Kremmer, E. Wolf, G. Brem, and M. Lipp. 1996. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 87:1037.
37. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547.
38. Matzinger, P. 1994. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12:991.
39. Janeway, C. A., Jr. 1992. The immune system evolved to discriminate infectious nonself from noninfectious self. Immunol. Today 13:11.