Cytokine expression in periodontal health and disease

Critical Reviews in Oral Biology and Medicine

Volumn 9, Issue 3, 1998, Pages 248-266

  Okada, H ^a   Murakami, S ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

Cytokine; Homeostasis; Periodontal tissue; Periodontitis

Indexed keywords

FIBROBLAST GROWTH FACTOR; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; SOMATOMEDIN; TRANSFORMING GROWTH FACTOR BETA;

HEALTH; HUMAN; IMMUNOMODULATION; INFECTION SENSITIVITY; INFLAMMATORY CELL; PATHOGENESIS; PERIODONTITIS; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE;

EID: 0032468328     PISSN: 10454411     EISSN: None     Source Type: Journal    
DOI: 10.1177/10454411980090030101     Document Type: Review

References (171)

1. AAP (1996). The potential role of growth and differentiation factors in periodontal regeneration. J Periodontol 67:545-553.
2. Alexander MB, Damoulis PD (1994). The role of cytokines in the pathogenesis of periodontal disease. Curr Opin Periodontol 1:39-53.
3. Alvares O, Klebe R, Grant G, Cochran DL (1995). Growth factor effects on the expression of collagenase and TIMP-1 in periodontal ligament cells. J Periodontol 66:552-558.
4. Barber S, Powell RN, Seymour GJ (1984). Surface markers of human gingival fibroblasts in vitro. J Oral Pathol 13:221-230.
5. Bartold PM (1993). Platelet-derived growth factor stimulates hyaluronate but not proteoglycan synthesis by human gingival fibroblasts in vitro. J Dent Res 72:1473-1480.
6. Bartold PM, Haynes DR (1991). Interleukin-6 production by human gingival fibroblasts. J Periodont Res 26:339-345.
7. Bauer J, Herrmann F (1991). Interleukin-6 in clinical medicine. Ann Hematol 62:203-210.
8. Bertolini DR, Nedwin GE, Bringman TS, Smith DD, Mundy GR (1986). Stimulation of bone resorption and inhibition of bone formation in vitro by human tumor necrosis factors. Nature 319:516-518.
9. Bickel M (1993). The role of interleukin-8 in inflammation and mechanisms of regulation. J Periodontol 64:456-460.
10. Blaise D, Olive D, Hirn M, Viens P, Lafage M, Attal M, et al. (1991). Prevention of acute GVHD by in vivo use of anti-interleukin-2 receptor monoclonal antibody (33B3.1): a feasibility trial in 15 patients. Bone Marrow Transplant 8:105-111.
11. Blieden TM, Semponski GD, Padilla I, Suchkova VN, Chess P, Phipps RP (1997). Periodontal fibroblast activation via CD40 (abstract). J Dent Res 76(Spec Iss):176.
12. Bom-van Noorloos AA, van der Meer JWM, van der Gevel JS, Schepens E, van Steenbergen TJM, Burger EH (1990). Bacteroides gingivalis stimulates bone resorption via interleukin-1 production by mononuclear cells. The relative role for B. gingivalis endotoxin. J Clin Periodontol 17:409-413.
13. Bomford R, Henderson BE (1989). Interleukin-1, inflammation and disease. New York: Elsevier.
14. Canalis E (1980). Effect of insulin-like growth factor-I on DNA synthesis in cultured rat calvaria. J Clin Invest 66:709-719.
15. Canalis E, McCarthy T, Centrella M (1988). Effects of basic fibroblast growth factor on bone formation in vitro. J Clin Invest 81:1572-1577.
16. Chaudhary LR, Spelsberg TC, Riggs BL (1992). Production of various cytokines by normal human osteoblast-like cells in response to interleukin-1β and tumor necrosis factor-α: lack of regulation by 17β-estradiol. Endocrinology 130:2528-2534.
17. Chen JK, Hoshi H, McKeehan WL (1987). Transforming growth factor type β specifically stimulates synthesis of proteoglycan in human adult arterial smooth muscle cells. Proc Natl Acad Sci USA 84:5287-5291.
18. Cochran DL, Rouse CA, Lynch SE, Graves DT (1993). Effects of platelet-derived growth factor isoforms on calcium release from neonatal mouse calvaria. Bone 14:53-58.
19. + cells can switch to interleukin 5 production and induce airway eosinophilia. J Exp Med 181:1229-1233.
20. Del Prete GF, De Carli M, Mastromauro C, Biagiotti R, Macchia D, Falagiani P, et al. (1991). Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production. J Clin Invest 88:346-350.
21. Dennison DK, Vallone DR, Pinero GJ, Rittman B, Caffesse RG (1994). Differential effect of TGF-β1 and PDGF on proliferation of periodontal ligament cells and gingival fibroblast. J Periodontol 65:641-648.
22. Dinarello CA (1988). Biology of interleukin 1. FASEB J 2: 108-115.
23. Dinarello CA and Worff SM (1993). The role of interleukin-1 in disease. N Engl J Med 328: 106-113.
24. Dongari-Bagtzoglou AI and Ebersole JL (1996). Gingival fibroblast cytokine profiles in Actinobacillus actinomycetemcomitans-associated periodontitis. J Periodontol 67: 871-878.
25. Eastcott JW, Yamashita K, Taubman MA, Harada Y, Smith DJ (1994). Adoptive transfer of cloned T helper cells ameliorates periodontal disease in nude rats. Oral Microbiol Immunol 9:284-289.
26. Ebersole JL, Taubman MA (1994). The protective nature of host responses in periodontal diseases. Periodontology 2000 5:112-141.
27. Edwards DR, Murphy G, Reynolds JJ, Whitham SE, Docherty AJ, Angel P, et al. (1987). Transforming growth factor beta. J Bone Miner Res 6:1899-1904.
28. Elias JA, Gustilo K, Baeder W, Freundlich B (1987). Synergistic stimulation of fibroblast prostaglandin production by recombinant interleukin 1 and tumor necrosis factor. J Immunol 138:3812-3816.
29. Fine A, Goldstein RH (1987). The effect of transforming growth factor-β on cell proliferation and collagen formation by lung fibroblasts. J Biol Chem 262:3897-3902.
30. Fiorentino DF, Bond MW, Mosmann TR (1989). Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 170:2081-2095.
31. Fujihashi K, Beagley KW, Kono Y, Aicher WK, Yamamoto M, DiFabio S, et al. (1993a). Gingival mononuclear cells from chronic inflammatory periodontal tissues produce interleukin (IL)-5 and IL-6 but not IL-2 and IL-4. Am J Pathol 142:1239-1250.
32. Fujihashi K, Kono Y, Beagley KW, Yamamoto M, McGhee JR, Mestecky J, et al. (1993b). Cytokines and periodontal disease: Immunopathological role of interleukins for B cell responses in chronic inflamed gingival tissues. J Periodontol 64:400-406.
33. Garrison SW, Nichols FC (1989). LPS-elicited secretory responses in monocytes: altered release of PGE2 but not IL-1β in patients with adult periodontitis. J Periodont Res 24:88-95.
34. Geivelis M, Turner DW, Peterson ED, Lamberts BL (1993). Measurements of interleukin-6 in gingival crevicular fluid from adults with destructive periodontal disease. J Periodontol 64: 980-983.
35. Gemmell E, Seymour GJ (1993). Interleukin-1, interleukin-6 and transforming growth factor-β production by human gingival mononuclear cells following stimulation with Porphyromonas gingivalis and Fusobacterium nucleatum. J Periodont Res 28:122-129.
36. Gemmell E, Seymour GL (1994). Modulation of immune responses to periodontal bacteria. Curr Opin Periodont 2:28-38.
37. Gemmell E, Seymour GJ (1995). γδ T lymphocytes in human periodontal disease tissue. J Periodontol 66:780-785.
38. Genco RJ, Mashimo PA, Kreggier G, Ellison SA (1977). Antibody-mediated effects on the periodontium. J Periodontol 45:330-337.
39. Gerosa F, Paganin C, Peritt D, Paiola F, Scupoli MT, Aste Amezaga M, et al. (1996). Interleukin-12 primes human CD4 and CD8T cell clones for high production of both interferon-gamma and interleukin-10. J Exp Med 183:2559-2569.
40. Giannobile WV, Finkelman RD, Lynch SE (1994a). Comparison of canine and non-human primate animal models for periodontal regenerative therapy: Results following a single administration of PDGF/IGF-I. J Periodont Res 65:1158-1168.
41. Giannobile WV, Whitson SW, Lynch SE (1994b). Synergistic effects of insulin-like growth factor-I (IGF-I) with other growth factors on bone formation in vitro (abstract). J Dent Res 73(Spec Iss):205.
42. Giannobile WV, Hernandez RA, Finkelman RD, Ryan S, Kiritsy CP, D'Andrea M, et al. (1996). Comparative effects of platelet-derived growth factor-BB, insulin-like growth factor-I alone and in combination on periodontal regeneration in Macaca fascicularis. J Periodont Res 31:301-312.
43. Gowen M, Nedwin GE, Mundy GR (1986). Preferential inhibition of cytokine-stimulated bone resorption by recombinant Interferon gamma. J Bone Miner Res 1:469-474.
44. Grant GA, Eisen AZ, Marmer BL, Roswit WT, Goldberg GI (1987). The activation of human skin fibroblast procollagenase. J Biol Chem 262:5886-5889.
45. Graves DT, Valentin-Opran A, Delgado R, Valente AJ, Mundy G, Piche J (1989). The potential role of platelet-derived growth factor as an autocrine and paracrine factor for bone cells. Connect Tissue Res 23:209-218.
46. Hanazawa S, Murakami Y, Hirose K, Amano S, Ohmori Y, Higuchi H, et al. (1991). Bacteroides (Porphyromonas) gingivalis fimbriae activate mouse peritoneal macrophages and induce gene expression and production of interleukin-1. Infect Immun 59:1972-1977.
47. Havemose-Poulsen A, Holmstrup P (1997). Factors affecting IL-1-mediated collagen metabolism by fibroblasts and the pathogenesis of periodontal disease: a review of the literature. Crit Rev Oral Biol Med 8:217-236.
48. Hazuda DJ, Lee JC, Young PR (1988). The kinetics of interleukin-1 secretion from activated monocytes. Differences between interleukin-1α and interleukin-1β. J Biol Chem 263:8473-8479.
49. Hefti A (1993). Aspects of cell biology of the normal periodontium. Periodontology 2000 3:64-75.
50. Heldin CH, Westermark B, Wasteson A (1981). Specific receptors for platelet-derived growth factor on cells derived from connective tissue and glia. Proc Natl Acad Sci USA 78:3663-3668.
51. Hirano T (1991). Interleukin-6. In: The cytokine handbook. 1st ed. Thomson A, editor. New York: Academic Press, pp. 169-190.
52. Hock JM, Canalis E (1994). Platelet-derived growth factor enhances bone cell replication but not differentiated function of osteoblast. Endocrinology 134:1423-1428.
53. Hock JM, Centrella M, Canalis E (1988). Insulin-like growth factor I has independent effects on bone matrix formation and replication. Endocrinology 122:254-260.
54. Horowitz MC (1993). Cytokines and estrogen in bone: Anti-osteoporotic effects. Science 260:626-627.
55. Hsu SM, Waldron JA, Xie SS, Barlogie B (1993). Expression of interleukin-6 in Castleman's disease. Hum Pathol 24:833-839.
56. Hughes EJ, Aubin JE, Heersche JN (1992). Differential chemotactic responses of different populations of fetal rat calvaria cells to platelet-derived growth factor and transforming growth factor beta. Bone Miner 19:63-74.
57. Idelgaufts H (1995). Dictionary of cytokine. 1st ed. Weinheim, Germany: VCH.
58. Ikezawa K, Hart CE, Williams DC, Narayanan AS (1997). Characterization of cementum derived growth factor as an insulin-like growth factor-I like molecule. Connect Tissue Res 36:309-319.
59. Ishimi Y, Miyaura C, Jin CH, Akatsu T, Abe E, Nakamura Y, et al. (1990). IL-6 is produced by osteoblasts and induces bone resorption. J Immunol 145:3297-3303.
60. Janeway CA Jr, Travers P (1994). Immunobiology - The immune system in health and disease. 1st rev. ed. Garland Publishing Inc.
61. Johnson RA, Boyce BF, Mundy GR, Roodman GD (1989). Tumors producing human tumor necrosis factor induce hypercalcemia and osteoclastic bone resorption in nude mice. Endocrinology 124:1424-1427.
62. Kawai T, Wilson ME, Nagasawa T, Watanabe H, Eastcott JW, Smith DJ, et al. (1997). Adoptive transfer of cloned antigen-specific Th1 lymphocytes produces periodontal bone loss (abstract). J Dent Res 76(Spec Iss):231.
63. Kishimoto T (1990). The biology of interleukin-6. Blood 74:1-10.
64. Kohler N, Lipton A (1974). Platelet as a source of fibroblast growth-promoting activity. Exp Cell Res 87:297-301.
65. Kono Y, Beagley KW, Fujihashi K, McGhee JR, Taga T, Hirano T, et al. (1991). Cytokine regulation of localized inflammation: induction of activated B cells and IL-6-mediated polyclonal IgG and IgA synthesis in inflamed human gingiva. J Immunol 146:1812-1821.
66. Kornman KS, Crane A, Wang HY, di Giovine FS, Newman MG, Pirk FW, et al. (1997). The interleukin-1 genotype as a severity factor in adult periodontal disease. J Clin Periodontol 24:72-77.
67. Kurihara N, Bertolini D, Suda T, Akiyama Y, Roodman GD (1990). 1L-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release. J Immunol 144:4226-4230.
68. Laiho M, Keski-Oja J (1989). Growth factors in the regulation of pericellular proteolysis: a review. Cancer Res 49:2533-2553.
69. Lark MW, Walakovits LA, Shah TK, Vanmiddlesworth J, Cameron PM, Lin T-Y (1990). Production and purification of prostromelysin and procollagenase from IL-1 beta-stimulated human gingival fibroblasts. Connect Tissue Res 25:49-65.
70. Le J, Vilcek J (1987). Biology of disease. Tumor necrosis factor and interleukin 1: Cytokines with multiple overlapping biological activities. Lab Invest 56:234-248.
71. Liblau RS, Singer SM, McDevitt HO (1995). Th1 and Th2 CD44+ T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol Today 16:34-38.
72. Lindemann RA, Economou JS (1988). Actinobacillus actinomycetemcomitans and Bacteroides gingivalis activate human peripheral monocytes to produce interleukin-1 and tumor necrosis factor. J Periodontol 59:728-730.
73. Lindemann RA, Economou JS, Rothermel H (1988). Production of interleukin-1 and tumor necrosis factor by human peripheral monocytes activated by periodontal bacteria and extracted lipopolysaccharides. J Dent Res 67:1131-1135.
74. Lowik CWGM, Van der Pluijm G, Bloys H, Hoekman K, Bijvoet LM, Aarden LA, et al. (1989). Parathyroid hormone (PTH) and PTH like protein (PLP) stimulate interleukin-6 production by osteogenic cells: a possible role of interleukin-6 in osteoclastogenesis. Biochem Biophys Res Commun 162:1546-1552.
75. Lundqvist C, Hammarström M-L (1993). T-cell receptor γδ-expressing intraepithelial lymphocytes are present in normal and chronically inflamed human gingiva. Immunology 79:38-45.
76. Lundqvist C, Baranov V, Teglund S, Hammarström S, Hammarström M-L (1994). Cytokine profile and ultra-structure of intraepithelial γδ T cells in chronically inflamed human gingiva suggest a cytotoxic effector function. J Immunol 153:2302-2312.
77. Lynch SE, Williams RC, Polson AM, Howell TH, Reddy MS, Zappa UE, et al. (1989). A combination of platelet-derived and insulin-like growth factors enhances periodontal regeneration. J Clin Periodontol 16:545-548.
78. Lynch SE, de Castilla GR, Williams RC, Kiritsy CP, Howell TH, Reddy MS, et al. (1991). The effects of short-term application of a combination of platelet-derived and insulin-like growth factors on periodontal wound healing. J Periodontol 62:458-467.
79. Mackler BF, Frostad KB, Robertson PB, Levy B (1977). Immunoglobulin bearing lymphocytes and plasma cells in human periodontal disease. J Periodont Res 12:37-45.
80. Manhart SS, Reinhardt RA, Payne JB, Seymour GJ, Gemmell E, Dyer JK, et al. (1994). Gingival cell IL-2 and IL-4 in early-onset periodontitis. J Periodontol 65:807-813.
81. Mantovani A, Bussolino F, Introna M (1997). Cytokine regulation of endothelial cell function: from molecular level to the bedside. Immunol Today 18:231-240.
82. Masada MP, Persson R, Kenny JS, Lee SW, Page RC, Allison AC (1990). Measurement of interleukin-1α and -1β in gingival crevicular fluid: Implications for the pathogenesis of periodontal disease. J Periodont Res 25:156-163.
83. Matsuda N, Lin WL, Kumar NM, Cho MI, Genco RJ (1992). Mitogenic, chemotactic, and synthetic responses of rat periodontal ligament cells to polypeptide growth factors in vitro. J Periodontol 63:515-525.
84. Matsuki Y, Yamamoto T, Hara K (1992). Detection of inflammatory cytokine messenger RNA (mRNA)-expressing cells in human inflamed gingiva by combined in situ hybridization and immunohistochemistry. Immunology 76:42-47.
85. McFarlane CG, Reynolds JJ, Meikle MC (1990). The release of interleukin-1β, tumor necrosis factor-α and Interferon-γ by cultured peripheral blood mononuclear cells from patients with periodontitis. J Periodont Res 25:207-214.
86. Meikle MC, Atkinson SJ, Ward RV, Murphy G, Reynolds JJ (1989). Gingival fibroblasts degrade type I collagen films when stimulated with tumor necrosis factor and interleukin 1: evidence that breakdown is mediated by metalloproteinases. J Periodont Res 24:207-213.
87. Mergia A, Eddy R, Abraham JA, Fiddes JC, Shows TB (1986). The genes for basic and acidic fibroblast growth factors are on different human chromosomes. Biochem Biophys Res Commun 138:644-651.
88. Miki Y, Shimabukuro Y, Kitamura M, Takayama S, Yanagi K, Ikezawa K, et al. (1994). The effect of application of bFGF on regeneration of the periodontal tissues (abstract). J Dent Res 73:354.
89. Mizel SB (1989). The interleukins. FASEB J 3:2379-2388.
90. Mizel SB, Dayer JM, Krane SM, Mergenhagen SE (1981). Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activation factor (Interleukin 1). Proc Natl Acad Aci USA 78:2474.
91. Mochan E, Armor L, Sporer R (1988). Interleukin 1 stimulation of plasminogen activator production in cultured gingival fibroblasts. J Periodont Res 23:28-32.
92. Mochizuki H, Hakeda Y, Wakatuki N, Usui N, Akashi S, Sato T, et al. (1992). Insulin-like growth factor-I supports formation and activation of osteoclasts. Endocrinology 131:2297-2305.
93. Moscatelli D, Presta M, Joseph-Silverstein J, Rifkin DB (1986). Both normal and tumor cells produce basic fibroblast growth factors. J Cell Physiol 129:273-276.
94. Mosmann TR, Coffman RL (1989). Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties. Ann Rev Immunol 7:145-173.
95. Mosmann TR, Sad S (1996). The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 17:138-146.
96. Moughal NA, Adonogianaki E, Thornhill MH, Kinane DF (1992). Endothelial cell leucocyte adhesion molecule-1 (ICAM-1) expression in gingival tissue during health and experimentally-induced gingivitis. J Periodont Res 27:623-630.
97. Mundy GR (1989). Local factors in bone remodeling. Rec Progr Horm Res 45:507-531.
98. Murakami S, Okada H (1997). Lymphocyte-fibroblast interactions. Crit Rev Oral Biol Med 8:40-50.
99. Murakami S, Shimabukuro Y, Saho T, Hino E, Kasai D, Hashikawa T, et al. (1997). Immunoregulatory roles of adhesive interactions between lymphocytes and gingival fibroblasts. J Periodont Res 32:110-114.
100. Murakami S, Hino E, Shimabukuro Y, Nozaki T, Kusumoto Y, Saho T, et al. (1998). Direct interaction between gingival fibroblasts and lymphoid cells induces inflammatory cytokine mRNA expression in gingival fibroblasts. J Dent Res (in press).
101. Narayanan SA, Yonemura K (1993). Purification and characterization of a novel growth factor from cementum. J Periodont Res 28:563-565.
102. Nguyen I, Dewhirst FE, Hauschka PV, Stashenko P (1991). Interleukin-1β stimulates bone resorption and inhibits bone formation in vivo. Lymphokine Cytokine Res 10:15-21.
103. Nozaki T, Kusumoto Y, Kitamura M, Murakami S, Okada H (1997). Differential mRNA expression of inflammatory cytokines in inflamed gingival tissues (abstract). J Dent Res 76:301.
104. Dates TW, Rouse CA, Cochran DL (1993). Mitogenic effects of growth factors on human periodontal ligament cells in vitro. J Periodontol 64:142-148.
105. Odake H, Koizumi F, Hatakeyama S, Furuta I, Nakagawa H (1993). Production of cytokines belonging to the interleukin-8 family by human gingival fibroblasts stimulated with interleukin-1β in culture. Exp Mol Pathol 58:14-24.
106. Ohasaki Y, Takahashi S, Scarcez T, Demulder A, Nishihara T, Williams R, et al. (1992). Evidence of an autocrine/paracrine role for interleukin-6 in bone resorption by giant cells from giant cell tumors of bone. Endocrinology 131:2229-2234.
107. Okada H, Kida T, Yamagami H (1983). Identification and distribution of immunocompetent cells in inflamed gingiva of human chronic periodontitis. Infect Immun 41:365-374.
108. Okada H, Murakami S, Kitamura M, Nozaki T, Kusumoto Y, Hirano H, et al. (1996). Diagnostic strategies of periodontitis based on the molecular mechanisms of periodontal tissue destruction. Oral Diseases 2:87-95.
109. Oppenheim JJ, Kovacs EJ, Matsushima K, Durum SK (1986). There is more than one interleukin 1. Immunol Today 7:45-56.
110. Overall CM, Wrana JL, Sodek J (1989). Independent regulation of collagenase 72-kDa progelatinase, and metalloproteinase inhibitor expression in human fibroblasts by transforming growth factor-β. J Biol Chem 264:1860-1869.
111. Overall CM, Wrana JL, Sodek J (1991). Induction of formative and resorptive cellular phenotypes in human gingival fibroblasts by TGF-β1 and concanavalin A: regulation of matrix metalloproteinases and TIMP. J Periodont Res 26:279-282.
112. Page RC (1991). The role of inflammatory mediators in the pathogenesis of periodontal disease. J Periodont Res 26:230-242.
113. Payne JB, Reinhardt RA, Masada MP, DuBois LM, Allison AC (1993). Gingival crevicular fluid IL-8: correlation with local IL-1β levels and patient estrogen status. J Periodont Res 28:451-453.
114. Peichl P, Ceska M, Effenberger F, Haberhauer G, Broell H, Lindley IJ (1991). Presence of NAP-/IL-8 in synovial fluids indicates a possible pathogenic role in rheumatoid arthritis. Scand J Immunol 34:333-339.
115. Pfeilschifter J, Oeschsner M, Naumann A, Gronwald RG, Minne HW, Ziegler R (1990). Stimulation of bone matrix apposition in vitro by local growth factors. A comparison between insulin-like growth factor-I, platelet-derived growth factor and transforming growth factor-β. Endodontology 127:69-75.
116. Piche JE, Carnes DL, Graves DT (1989). Initial characterization of cells derived from the human periodontia. J Dent Res 68:761-767.
117. Reinhardt RA, Masada MP, Kaldahl WB, DuBois LM, Kornman KS, Choi J-I, et al. (1993). Gingival fluid IL-1 and IL-6 levels in refractory periodontitis. J Clin Periodontol 20:225-231.
118. Richards D, Rutherford RB (1990). Interleukin-1 regulation of procollagenase mRNA and protein in periodontal fibroblasts in vitro. J Periodont Res 25:222-229.
119. Romagnani S, Maggi E, Del Prete G (1994). An alternative view of the Th1/Th2 switch hypothesis in HIV infection. AIDS Res Hum Retroviruses 10:iii-ix.
120. Ross R, Glomset I, Kariya B, Harku L (1974). A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc Natl Acad Sci USA 71:1207-1210.
121. Rossomando EF, White L (1993). A novel method for the detection of TNF-alpha in gingival crevicular fluid. J Periodontol 64:445-449.
122. Rossomando EF, Kennedy JE, Hadjimichael J (1990). Tumor necrosis factor alpha in gingival crevicular fluid as a possible indicator of periodontal disease in humans. Arch Oral Biol 35:431-434.
123. Rutherford RB, Niekrash CE, Kennedy JE, Charette MF (1992). Platelet-derived and insulin-like growth factors stimulate regeneration of periodontal attachment in monkeys. J Periodont Res 27:285-290.
124. Rutherford RB, Ryan ME, Kennedy JE, Tucker MM, Charett MF (1993). Platelet-derived growth factor and dexamethasone combined with a collagen matrix induce regeneration of the periodontium in monkeys. J Clin Periodontol 20:537-544.
125. Saito K, Kusumoto Y, Hirano H, Hirano F, Nozaki T, Ogo H, et al. (1997). Inflammatory cytokine mRNA expression in human gingival epithelial cells (abstract). J Dent Res 76:441.
126. Salgame P, Abrams JS, Clayberger C, Goldstein H, Convit J, Modlin RL, et al. (1991). Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science 254:279-282.
127. Schmidt JA, Mizel SB, Cohen D, Green I (1982). Interleukin 1, a potential regulator of fibroblast proliferation. J Immunol 128:2177-2182.
128. Schweigerer L, Ferrara N, Haaparanta T, Neufeld G, Gospodarowicz D (1988). Basic fibroblast growth factor: expression in cultured cells derived from corneal endothelium and lens epithelium. Exp Eye Res 46:71-80.
129. + T-cell subsets in the regulation of parasite immunity and disease. Immunol Rev 112:161-182.
130. Seymour GJ (1987). Possible mechanisms involved in the immunoregulation of chronic inflammatory periodontal disease. J Dent Res 66:2-9.
131. Seymour GJ, Crouch MS, Powell RN, Brooks D, Beckman I, Zola H, et al. (1982). The identification of lymphoid cell subpopulations in sections of human lymphoid tissue and gingivitis in children using monoclonal antibodies. J Periodont Res 17:247-256.
132. Seymour GJ, Powell RN, Cole KL, Aitken JF, Brooks D, Beckman I, et al. (1983). Experimental gingivitis in humans: a histochemical and immunological characterisation of the lymphoid cell subpopulations. J Periodont Res 18:375-385.
133. Seymour GL, Gemmell E, Kjeldsen M, Yamazaki K, Nakajima T, Hara K (1996). Cellular immunity and hypersensitivity as components of periodontal destruction. Oral Diseases 2:96-101.
134. Shimabukuro Y, Murakami S, Okada H (1992). Interferon-gamma-dependent immunosuppressive effects of human gingival fibroblasts. Immunology 76:344-347.
135. Shimabukuro Y, Murakami S, Okada H (1996). Antigen-presenting cell function of IFNγ-treated human gingival fibroblasts. J Periodont Res 31:217-228.
136. Shimizu N, Ogura N, Yamaguchi H (1992). Stimulation by interleukin-1 of interleukin-6 production by human periodontal ligament cells. Arch Oral Biol 37:743-748.
137. Shimizu N, Yamaguchi H, Goseki T, Ogura N, Saito K, Takiguchi H, et al. (1994). Cyclic-tension force stimulates interleukin-1β production by human periodontal ligament cells. J Periodont Res 29:328-333.
138. Skerka C, Irving SG, Bialonski A, Zipfel PF (1993). Cell type specific expression of members of the IL-8/NAP-1 gene family. Cytokine 5:112-116.
139. Slootweg MC, Most WW, van Beek E, Schot LP, Papopoulos SE, Lowick CW (1992). Osteoclast forming together with interleukin-6 production in mouse long bones is increased by insulin-like growth factor-I. J Endocrinol 132:433-438.
140. Stashenko P, Dewhirst FE, Peros WJ, Kent RL, Age JM (1987a). Synergistic interactions between interleukin-1, tumor necrosis factor and lymphotoxin in bone resorption. J Immunol 138:1464-1468.
141. Stashenko P, Dewhirst FE, Rooney ML, Desjardins LA, Heeley JD (1987b). Interleukin-1β is a potent inhibitor of bone formation in vitro. J Bone Miner Res 2:559-565.
142. Stashenko P, Fujiyoshi P, Obernesser MS, Prostak L, Haffajee AD, Socransky SS (1991). Levels of interleukin Iß in tissue from sites of active periodontal disease. J Clin Periodontol 18:548-554.
143. Takada H, Mihara J, Morisaki I, Hamada S (1991). Induction of interleukin-1 and -6 in human gingival fibroblast cultures stimulated with Bacteroides lipopolysaccharides. Infect Immun 59:295-301.
144. Takashiba S, Takigawa M, Myokai F, Nishimura F, Chihara T, Kurihara H, et al. (1992). Interleukin-8 is a major neutrophil chemotactic factor derived from cultured human gingival fibroblasts stimulated with interleukin-1β or tumor necrosis factor α. Infect Immun 60:5253-5258.
145. Takayama S, Murakami S, Miki Y, Ikezawa K, Tasaka S, Terashima A, et al. (1997). Effects of basic fibroblast growth factor on human periodontal ligament cells. J Periodont Res 32:667-675.
146. Tamura M, Tokuda M, Nagaoka S, Takada H (1992). Lipopolysaccharides of Bacteroides intermedius (Prevotella intermedia) and Bacteroides (Porphyromonas) gingivalis induce interleukin-8 gene expression in human gingival fibroblast cultures. Infect Immun 60:4932-4937.
147. Tamura T, Udagawa N, Takahashi N, Miyaura C, Tanaka S, Yamada Y, et al. (1993). Soluble interleukin-6 receptor triggers osteoclast formation by interleukin-6. Proc Natl Acad Sci USA 90:11924-11928.
148. Tatakis DN (1993). Interleukin-1 bone metabolism: A review. J Periodontol 64:416-431.
149. Taubman M, Eastcott JW, Shimauchi H, Takeichi O, Smith DJ (1994). Modulatory role of T lymphocytes in periodontal inflammation. In: Molecular pathogenesis of periodontal diseases. Genco R, Hamada S, Lehner T, McGhee J, Mergenhagen S, editors. Washington, DC: ASM Press, pp. 147-157.
150. Taubman MA, Stoufi ED, Ebersole JL, Smith DJ (1984). Phenotypic studies of cells from periodontal disease tissues. J Periodont Res 19:587-590.
151. Terranova VP, Odziemiec C, Tweden KS, Spadone DP (1989). Repopulation of dentin surfaces by periodontal ligament cells and endothelial cells: Effect of basic fibroblast growth factor. J Periodontol 60:293-301.
152. Tewari DS, Qian Y, Tewari M, Pieringer J (1994). Mechanistic features associated with induction of metalloproteinases in human gingival fibroblasts by interleukin-1. Arch Oral Biol 39:657-664.
153. van der Pluijm G, Most W, van der Wee-Pals L, De Groot H, Papapoulos S, Lowic C (1991). Two distinct effects of recombinant human tumor necrosis factor-α on osteoclast development and subsequent resorption of mineralized matrix. Endocrinology 129:1596-1604.
154. Van Dyke TE, Lester MA, Shapira L (1993). The role of the host response in periodontal disease progression. J Periodontol 64:792-806.
155. Varga I, Rosenbloom J, Jimenez SA (1987). Transforming growth factor-β (TGF-β) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts. Biochem J 247:597-604.
156. Wahl SM, Allen JB, Costa GL, Wong HL, Dasch JR (1993a). Reversal of acute and chronic synovial inflammation by anti-transforming growth factor beta. J Exp Med 177:225-230.
157. Wahl SM, Costa GL, Mizel DE, Allen JB, Skaleric U, Mangan DF (1993b). Role of transforming growth beta in the pathophysiology of chronic inflammation. J Periodontol 64:450-455.
158. Waldmann TA, Goldman C, Top L, Grant A, Burton J, Bamford R, et al. (1993). The interleukin-2 receptor: a target for immunotherapy. Ann NY Acad Sci 685:603-610.
159. Walsh LJ, Stritzel F, Yamazaki K, Bird PS, Gemmell E, Seymour GJ (1989). Interleukin-1 and interleukin-1 inhibitor production by human adherent cells stimulated with periodontopathic bacteria. Arch Oral Biol 34:679-683.
160. Waxman J, Balkwill F, editors (1992). Interleukin 2. Oxford: Blackwell Scientific Publ.
161. Westergren-Thorsson G, Särnstrand B, Fransson L-A, Malmström A (1990). TGF-β enhances the production of hyaluronan in human lung but not in skin fibroblasts. Exp Cell Res 186:192-195.
162. Westermark B, Wasteson A (1976). A platelet factor stimulating human normal glial cells. Exp Cell Res 98:170-174.
163. Williams RC (1990). Periodontal disease. N Engl J Med 322:373-376.
164. Wilton JMA, Bampton JLM, Hurst TJ, Caves J, Powell JR (1993). Interleukin-1β and IgG subclass concentrations in gingival crevicular fluid from patients with adult periodontitis. Arch Oral Biol 38:55-60.
165. Windhagen A, Anderson DE, Carrizosa A, Williams RE, Hafler DA (1996). IL-12 induces human T cells secreting IL-10 with IFN-gamma. J Immunol 157:1127-1131.
166. Yamamoto M, Fujihashi K, Hiroi T, McGhee JR, Van Dyke TE, Kiyono H (1997). Molecular and cellular mechanisms for periodontal diseases: role of Th1 and Th2 type cytokines in induction of mucosal inflammation. J Periodont Res 32:115-119.
167. Yamamura M, Uyemura K, Deans RJ, Weinberg K, Rea T, Bloom B, et al. (1991). Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science 254:277-279.
168. Yamashita K, Eastcott JW, Taubman MA, Smith DJ, Cox DS (1991). Effect of adoptive transfer of cloned Actinobacillus actinomycetemcomitans-specific T helper cells on periodontal disease. Infect Immun 59:1529-1534.
169. Yamazaki K, Nakajima T, Aoyagi T, Hara K (1993). Immunohistological analysis of memory T lymphocytes and activated B lymphocytes in tissues with periodontal disease. J Periodont Res 28:324-334.
170. Yamazaki K, Nakajima T, Gemmell E, Polak B, Seymour GJ, Hara K (1994). IL-4 and IL-6-producing cells in human periodontal disease tissue. J Oral Pathol Med 23:347-353.
171. Yoshizaki K, Matsuda T, Nishimoto N, Kuritani T, Taeho L, Aozasa K, et al. (1989). Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease. Blood 74:1360-1367.