Conversion of a T cell antagonist into an agonist by repairing a defect in the TCR/Peptide/MHC interface: Implications for TCR signaling

Immunity

Volumn 13, Issue 4, 2000, Pages 475-484

  Baker, Brian M ^a   Gagnon, Susan J ^c   Biddison, William E ^c   Wiley, Don C ^a,b  

^a HARVARD UNIVERSITY   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; HLA A2 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROLINE; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; TAX PROTEIN;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; EFFECTOR CELL; HUMAN; HUMAN T CELL LEUKEMIA VIRUS 1; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR AFFINITY; T LYMPHOCYTE; THERMODYNAMICS;

EID: 0033711639     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)00047-9     Document Type: Article

References (46)

1. T-cell receptor affinity and thymocyte positive selection
2. Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands
3. Lack of strict correlation of functional sensitization with the apparent affinity of MHC/peptide complexes for the TCR
4. Structural, biochemical, and biophysical studies of HLA-A2/altered peptide ligands binding to viral-peptide-specific human T-cell receptors
5. Protein-protein interactions of HIV-1 reverse transcriptase: Implication of central and C-terminal regions in subunit binding
6. The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers
7. A functional hot spot for antigen recognition in a superagonist TCR/MHC complex
8. Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids
9. Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical
10. The entropic cost of bound water in crystals and biomolecules
11. Response to a protein structure to cavity-creating mutations and its relation to the hydrophobic effect
12. Evidence for multivalent structure of T-cell antigen receptor complex
13. Multivalent structure of an αβT cell receptor
14. HLA-A2-peptide complexes: Refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides
15. Structure of the complex between T-cell receptor, viral peptide, and HLA-A2
16. Assembly, specific binding, and crystallization of a human TCR-αβ with an antigenic tax peptide from human T lymphotropic virus type 1 and the class I MHC molecule HLA-A2
17. Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen
18. Peptide recognition by two HLA-A2/Tax11-19-specific T cell clones in relationship to their MHC/peptide/TCR crystal structures
19. Structure of a covalently stabilized complex of a human αβ T cell receptor, influenza HA peptide, and MHC class II molecule, HLA-DR1
20. Effect of cavity-creating mutations in the hydrophobic core of chymotrypsin inhibitor 2
21. Ligands for the T-cell receptor: Hard times for avidity models
22. Cross-linking and conformational change in T-cell receptors: Role in activation and in repertoire selection
23. Nonlinear least-squares analysis
24. High-and low-potency ligands with similar affinities for the TCR: The importance of kinetics in TCR signaling
25. The structure and stability of an HLA-A201/Octameric Tax peptide complex with an empty conserved peptide-N-terminal binding site
26. Comparison of experimental binding data and theoretical models in proteins containing subunits
27. SURFNET: A program for visualizing molecular surfaces, cavities, and intermolecular interactions
28. A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists
29. The antigenic identity of peptide-MHC complexes: A comparison of the conformations of five viral peptides presented by HLA-A2
30. Kinetics of the T-cell receptor binding to peptide/I-K(k) complexes: Correlation of the dissociation rate with T-cell responsiveness
31. Kinetic proofreading in T-cell receptor signal transduction
32. On the nature of allosteric transitions: A plausible model
33. Improving biosensor analysis
34. Exploiting the basis of proline recognition by SH3 and WW domains: Design of N-substituted inhibitors
35. Peptide velcro: Design of a heterodimeric coiled coil
36. Mechanisms of cooperativity and allosteric regulation in proteins
37. Ligand-specific oligomerization of T-cell receptor molecules
38. The crystal structure of a T cell receptor in complex with peptide and MHC class II
39. Assembly of the TCR/CD3 complex: CD3ε/δ and CD3ε/γ dimers associate indistinctly with both TCRα and TCRβ chains. Evidence for a double TCR heterodimer model
40. Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology
41. Peptide antagonism and T cell receptor interactions with peptide-MHC complexes
42. Self-MHC-restricted recognized by an alloreactive T lymphocyte clone
43. + cytotoxic T lymphocytes from patients with HTLV-1 associated disease: Evidence for oligoclonal expansion
44. Human cell-adhesion molecule CD2 binds CD58 (LFA-3) with a very low affinity and an extremely fast dissociation rate but does not bind CD48 or CD59