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1
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0036780841
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Regulation of mast-cell and basophil function and survival by IgE
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Kawakami T., Galli S.J. Regulation of mast-cell and basophil function and survival by IgE. Nat. Rev. Immunol. 2:2002;773-786.
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Kawakami, T.1
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2
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0037470496
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Antibody multispecificity mediated by conformational diversity
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The binding of IgE to FcεRI without the addition of antigen stimulates mast cell proliferation without overt degranulation. This paper shows that the crystal structure of the anti-DNP IgE, which has strong activity for this function, has multiple conformations, suggesting that the Fab of this IgE may bind with low affinity to different cell surface proteins to activate cellular enzymes that result in intracellular signals.
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James L.C., Roversi P., Tawfik D.S. Antibody multispecificity mediated by conformational diversity. Science. 299:2003;1362-1367 The binding of IgE to FcεRI without the addition of antigen stimulates mast cell proliferation without overt degranulation. This paper shows that the crystal structure of the anti-DNP IgE, which has strong activity for this function, has multiple conformations, suggesting that the Fab of this IgE may bind with low affinity to different cell surface proteins to activate cellular enzymes that result in intracellular signals.
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Science
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James, L.C.1
Roversi, P.2
Tawfik, D.S.3
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3
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0037099546
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Antigen-independent induction of histamine synthesis by immunoglobulin E in mouse bone marrow-derived mast cells
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Tanaka S., Takasu Y., Mikura S., Satoh N., Ichikawa A. Antigen-independent induction of histamine synthesis by immunoglobulin E in mouse bone marrow-derived mast cells. J. Exp. Med. 196:2002;229-235.
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Tanaka, S.1
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Ichikawa, A.5
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4
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0242389876
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Proceedings of the fourth international workshop on signal transduction in the activation and development of mast cells and basophils
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Proceedings of the fourth international workshop on signal transduction in the activation and development of mast cells and basophils. Mol Immunol 2002, 38:1171-1378.
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Mol Immunol
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5
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0035817631
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High resolution mapping of mast cell membranes reveals primary and secondary domains of FcεRI and LAT
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Wilson B.S., Pfeiffer J.R., Surviladze Z., Gaudet E.A., Oliver J.M. High resolution mapping of mast cell membranes reveals primary and secondary domains of FcεRI and LAT. J. Cell. Biol. 154:2001;645-658.
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Wilson, B.S.1
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Oliver, J.M.5
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6
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0031041581
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Compartmentalized activation of the high affinity immunoglobulin E receptor within membrane domains
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Field K.A., Holowka D., Baird B. Compartmentalized activation of the high affinity immunoglobulin E receptor within membrane domains. J. Biol. Chem. 272:1997;4276-4280.
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Field, K.A.1
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7
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0036498594
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Transmembrane phosphoprotein Csk-binding protein/phosphoprotein associated with glycosphingolipid-enriched microdomains as a negative feedback regulator of mast cell signaling through the FcεRI
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Ohtake H., Ichikawa N., Okada M., Yamashita T. Transmembrane phosphoprotein Csk-binding protein/phosphoprotein associated with glycosphingolipid-enriched microdomains as a negative feedback regulator of mast cell signaling through the FcεRI. J. Immunol. 168:2002;2087-2090.
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Ohtake, H.1
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8
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0036347746
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Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation
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3 by PI3K recruits proteins containing PH domains to the membrane that cooperate with signals generated by Syk. In the absence of Fyn, there is about a 70% decrease in mast cell degranulation.
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3 by PI3K recruits proteins containing PH domains to the membrane that cooperate with signals generated by Syk. In the absence of Fyn, there is about a 70% decrease in mast cell degranulation.
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Nat. Immunol.
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, pp. 741-748
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Parravicini, V.1
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Gonzalez-Espinosa, C.5
Furumoto, Y.6
Saitoh, S.7
Samelson, L.E.8
O'shea, J.J.9
Rivera, J.10
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9
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0036724531
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Fer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cells
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Craig A.W.B., Greer P.A. Fer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cells. Mol. Cell. Biol. 22:2002;6363-6374.
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Mol. Cell. Biol.
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Craig, A.W.B.1
Greer, P.A.2
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10
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0037100457
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Inhibition of allergic inflammation in the airways using aerosolized antisense to Syk kinase
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Stenton G.R., Ulanova M., Dery R.E., Merani S., Kim M.K., Gilchrist M., Puttagunta L., Musat-Marcu S., James D., Schreiber A.D., Befus A.D. Inhibition of allergic inflammation in the airways using aerosolized antisense to Syk kinase. J. Immunol. 169:2002;1028-1036.
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J. Immunol.
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Stenton, G.R.1
Ulanova, M.2
Dery, R.E.3
Merani, S.4
Kim, M.K.5
Gilchrist, M.6
Puttagunta, L.7
Musat-Marcu, S.8
James, D.9
Schreiber, A.D.10
Befus, A.D.11
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11
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0036721771
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Intracellular single-chain variable fragments directed to the Src homology 2 domains of Syk partially inhibit FcεRI signaling in the RBL-2H3 cell line
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Dauvillier S., Merida P., Visintin M., Cattaneo A., Bonnerot C., Dariavach P. Intracellular single-chain variable fragments directed to the Src homology 2 domains of Syk partially inhibit FcεRI signaling in the RBL-2H3 cell line. J. Immunol. 169:2002;2274-2283.
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J. Immunol.
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Dauvillier, S.1
Merida, P.2
Visintin, M.3
Cattaneo, A.4
Bonnerot, C.5
Dariavach, P.6
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12
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0036736779
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Proteasome-dependent regulation of Syk tyrosine kinase levels in human basophils
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Youssef L.A., Wilson B.S., Oliver J.M. Proteasome-dependent regulation of Syk tyrosine kinase levels in human basophils. J. Allergy Clin. Immunol. 110:2002;366-373.
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J. Allergy Clin. Immunol.
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Youssef, L.A.1
Wilson, B.S.2
Oliver, J.M.3
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13
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0037020143
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Activation of Syk tyrosine kinase is required for c-Cbl-mediated ubiquitination of FcεRI and Syk in RBL cells
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Syk kinase activity is required for the ubiquitination of Syk and the β and γ subunits of FcεRI, and c-Cbl is the E3 ligase responsible for this ubiquitination. This study suggests that the proteosome pathway degrades FcεRI and Syk after receptor aggregation.
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Paolini R., Molfetta R., Beitz L.O., Zhang J., Scharenberg A.M., Piccoli M., Frati L., Siraganian R., Santoni A. Activation of Syk tyrosine kinase is required for c-Cbl-mediated ubiquitination of FcεRI and Syk in RBL cells. J. Biol. Chem. 277:2002;36940-36947 Syk kinase activity is required for the ubiquitination of Syk and the β and γ subunits of FcεRI, and c-Cbl is the E3 ligase responsible for this ubiquitination. This study suggests that the proteosome pathway degrades FcεRI and Syk after receptor aggregation.
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J. Biol. Chem.
, vol.277
, pp. 36940-36947
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Paolini, R.1
Molfetta, R.2
Beitz, L.O.3
Zhang, J.4
Scharenberg, A.M.5
Piccoli, M.6
Frati, L.7
Siraganian, R.8
Santoni, A.9
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14
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0036888879
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Phosphorylation of Tyr342 in the linker region of Syk is critical for FcεRI signaling in mast cells
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This paper further demonstrates that the linker region of Syk is essential for mast cells signaling.
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Zhang J., Berenstein E., Siraganian R.P. Phosphorylation of Tyr342 in the linker region of Syk is critical for FcεRI signaling in mast cells. Mol. Cell. Biol. 22:2002;8144-8154 This paper further demonstrates that the linker region of Syk is essential for mast cells signaling.
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Mol. Cell. Biol.
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Zhang, J.1
Berenstein, E.2
Siraganian, R.P.3
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15
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0037063364
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Silencing of Bruton's tyrosine kinase (Btk) using short interfering RNA duplexes (siRNA)
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Heinonen J.E., Smith C.I.E., Nore B.F. Silencing of Bruton's tyrosine kinase (Btk) using short interfering RNA duplexes (siRNA). FEBS Lett. 527:2002;274-278.
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FEBS Lett.
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Heinonen, J.E.1
Smith, C.I.E.2
Nore, B.F.3
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16
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0036570013
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Enlargement of secretory vesicles by protein tyrosine phosphatase PTP-MEG2 in rat basophilic leukemia mast cells and Jurkat T cells
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Wang X.D., Huynh H., Gjorloff-Wingren A., Monosov E., Stridsberg M., Fukuda M., Mustelin T. Enlargement of secretory vesicles by protein tyrosine phosphatase PTP-MEG2 in rat basophilic leukemia mast cells and Jurkat T cells. J. Immunol. 168:2002;4612-4619.
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J. Immunol.
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Wang, X.D.1
Huynh, H.2
Gjorloff-Wingren, A.3
Monosov, E.4
Stridsberg, M.5
Fukuda, M.6
Mustelin, T.7
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17
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0036195935
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Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice
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Fukao T., Yamada T., Tanabe M., Terauchi Y., Ota T., Takayama T., Asano T., Takeuchi T., Kadowaki T., Hata J., Koyasu S. Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice. Nat. Immunol. 3:2002;295-304.
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Nat. Immunol.
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Fukao, T.1
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Ota, T.5
Takayama, T.6
Asano, T.7
Takeuchi, T.8
Kadowaki, T.9
Hata, J.10
Koyasu, S.11
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18
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0036569406
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SHIP negatively regulates IgE plus antigen-induced IL-6 production in mast cells by inhibiting NF-κB activity
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Kalesnikoff J., Baur N., Leitges M., Hughes M.R., Damen J.E., Huber M., Krystal G. SHIP negatively regulates IgE plus antigen-induced IL-6 production in mast cells by inhibiting NF-κB activity. J. Immunol. 168:2002;4737-4746.
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J. Immunol.
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Kalesnikoff, J.1
Baur, N.2
Leitges, M.3
Hughes, M.R.4
Damen, J.E.5
Huber, M.6
Krystal, G.7
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19
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0036200415
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Phosphoinositide 3-kinase γ is an essential amplifier of mast cell function
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2+ and degranulation.
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2+ and degranulation.
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(2002)
Immunity
, vol.16
, pp. 441-451
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Laffargue, M.1
Calvez, R.2
Finan, P.3
Trifilieff, A.4
Barbier, M.5
Altruda, F.6
Hirsch, E.7
Wymann, M.P.8
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21
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0036258094
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Protein kinase C-δ is a negative regulator of antigen-induced mast cell degranulation
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Leitges M., Gimborn K., Elis W., Kalesnikoff J., Hughes M.R., Krystal G., Huber M. Protein kinase C-δ is a negative regulator of antigen-induced mast cell degranulation. Mol. Cell. Biol. 22:2002;3970-3980.
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Mol. Cell. Biol.
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Leitges, M.1
Gimborn, K.2
Elis, W.3
Kalesnikoff, J.4
Hughes, M.R.5
Krystal, G.6
Huber, M.7
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22
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0036604342
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Phospholipases D1 and D2 regulate different phases of exocytosis in mast cells
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Choi W.S., Kim Y.M., Combs C., Frohman M.A., Beaven M.A. Phospholipases D1 and D2 regulate different phases of exocytosis in mast cells. J. Immunol. 168:2002;5682-5689.
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J. Immunol.
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Choi, W.S.1
Kim, Y.M.2
Combs, C.3
Frohman, M.A.4
Beaven, M.A.5
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23
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0036799931
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Continual production of phosphatidic acid by phospholipase D is essential for antigen-stimulated membrane ruffling in cultured mast cells
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O'Luanaigh N., Pardo R., Fensome A., Allen-Baume V., Jones D., Holt M.R., Cockcroft S. Continual production of phosphatidic acid by phospholipase D is essential for antigen-stimulated membrane ruffling in cultured mast cells. Mol. Biol. Cell. 13:2002;3730-3746.
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O'luanaigh, N.1
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Jones, D.5
Holt, M.R.6
Cockcroft, S.7
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24
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0036227573
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Antigen-stimulated activation of phospholipase D1b by Rac1, ARF6, and PKCα in RBL-2H3 cells
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Powner D.J., Hodgkin M.N., Wakelam M.J.O. Antigen-stimulated activation of phospholipase D1b by Rac1, ARF6, and PKCα in RBL-2H3 cells. Mol. Biol. Cell. 13:2002;1252-1262.
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Mol. Biol. Cell.
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Powner, D.J.1
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Wakelam, M.J.O.3
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25
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0037052338
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2+ signals triggered by different phospholipid pathways in antigen stimulation of human mast cells
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2+ signals triggered by different phospholipid pathways in antigen stimulation of human mast cells. J. Biol. Chem. 277:2002;17255-17262.
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J. Biol. Chem.
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Melendez, A.J.1
Khaw, A.K.2
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27
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0037129193
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SWAP-70 is a guanine-nucleotide-exchange factor that mediates signalling of membrane ruffling
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•] describe the function of SWAP-70 and its expression in mast cells. This protein is shown to be a guanine-nucleotide exchange factor and is present in immature but not mature mast cells and BMMCs. There is decreased degranulation of SWAP-70-negative BMMCs; however, the lack of SWAP-70 in mature mast cells suggests that SWAP-70 is not essential for degranulation.
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•] describe the function of SWAP-70 and its expression in mast cells. This protein is shown to be a guanine-nucleotide exchange factor and is present in immature but not mature mast cells and BMMCs. There is decreased degranulation of SWAP-70-negative BMMCs; however, the lack of SWAP-70 in mature mast cells suggests that SWAP-70 is not essential for degranulation.
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(2002)
Nature
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Shinohara, M.1
Terada, Y.2
Iwamatsu, A.3
Shinohara, A.4
Mochizuki, N.5
Higuchi, M.6
Gotoh, Y.7
Ihara, S.8
Nagata, S.9
Itoh, H.10
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28
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0037172775
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Transbilayer asymmetry of phospholipids in the plasma membrane regulates exocytotic release in mast cells
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Kato N., Nakanishi M., Hirashima N. Transbilayer asymmetry of phospholipids in the plasma membrane regulates exocytotic release in mast cells. Biochemistry. 41:2002;8068-8074.
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Biochemistry
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Kato, N.1
Nakanishi, M.2
Hirashima, N.3
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29
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0037029646
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Vav1 is a component of transcriptionally active complexes
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After prolonged activation of FcεRI, the cytoplasmic protein Vav1 is detected in the nucleus, where it is an integral component of transcriptionally active NFAT- and NF-κB-like complexes.
-
Houlard M., Arudchandran R., Regnier-Ricard F., Germani A., Gisselbrecht S., Blank U., Rivera J., Varin-Blank N. Vav1 is a component of transcriptionally active complexes. J. Exp. Med. 195:2002;1115-1127 After prolonged activation of FcεRI, the cytoplasmic protein Vav1 is detected in the nucleus, where it is an integral component of transcriptionally active NFAT- and NF-κB-like complexes.
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J. Exp. Med.
, vol.195
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Houlard, M.1
Arudchandran, R.2
Regnier-Ricard, F.3
Germani, A.4
Gisselbrecht, S.5
Blank, U.6
Rivera, J.7
Varin-Blank, N.8
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30
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0037379217
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Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (FcεRI) in mast cells
-
These studies further dissect the essential role of SLP-76 in FcεRI-induced signaling. The amino-terminal and GADS-binding domains of SLP-76, but not the SH2 domain, are essential for FcεRI-mediated degranulation and IL-6 secretion. However, there are differences between the SLP-76 domains required for degranulation and those required for the release of IL-6.
-
Kettner A., Pivniouk V., Kumar L., Falet H., Lee J.S., Mulligan R., Geha R.S. Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (FcεRI) in mast cells. Mol. Cell. Biol. 23:2003;2395-2406 These studies further dissect the essential role of SLP-76 in FcεRI-induced signaling. The amino-terminal and GADS-binding domains of SLP-76, but not the SH2 domain, are essential for FcεRI-mediated degranulation and IL-6 secretion. However, there are differences between the SLP-76 domains required for degranulation and those required for the release of IL-6.
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Mol. Cell. Biol.
, vol.23
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Kettner, A.1
Pivniouk, V.2
Kumar, L.3
Falet, H.4
Lee, J.S.5
Mulligan, R.6
Geha, R.S.7
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31
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0037430982
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Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cells
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Fujii Y., Wakahara S., Nakao T., Hara T., Ohtake H., Komurasaki T., Kitamura K., Tatsuno A., Fujiwara N., Hozumi N., et al. Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cells. FEBS Lett. 540:2003;111-116.
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FEBS Lett.
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Fujii, Y.1
Wakahara, S.2
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Ohtake, H.5
Komurasaki, T.6
Kitamura, K.7
Tatsuno, A.8
Fujiwara, N.9
Hozumi, N.10
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33
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0037121939
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Non-T cell activation linker (NTAL): A transmembrane adaptor protein involved in immunoreceptor signaling
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2+ influx.
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2+ influx.
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J. Exp. Med.
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Brdicka, T.1
Imrich, M.2
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Spicka, J.6
Hilgert, I.7
Luskova, P.8
Draber, P.9
Novak, P.10
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34
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20244366689
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Requirement of Gab2 for mast cell development and KitL/c-Kit signaling
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Nishida K., Wang L., Morii E., Park S.J., Narimatsu M., Itoh S., Yamasaki S., Fujishima M., Ishihara K., Hibi M., et al. Requirement of Gab2 for mast cell development and KitL/c-Kit signaling. Blood. 99:2002;1866-1869.
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Blood
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Nishida, K.1
Wang, L.2
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Park, S.J.4
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Itoh, S.6
Yamasaki, S.7
Fujishima, M.8
Ishihara, K.9
Hibi, M.10
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35
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0035849822
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Essential role for Gab2 in the allergic response
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Gu H.H., Saito K., Klaman L.D., Shen J.Q., Fleming T., Wang Y.P., Pratt J.C., Lin G.S., Lim B., Kinet J.P., Neel B.G. Essential role for Gab2 in the allergic response. Nature. 412:2001;186-190.
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Nature
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Gu, H.H.1
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Shen, J.Q.4
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Wang, Y.P.6
Pratt, J.C.7
Lin, G.S.8
Lim, B.9
Kinet, J.P.10
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36
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0036569710
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The adapter molecule Gab2 regulates FcεRI-mediated signal transduction in mast cells
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Xie Z.H., Ambudkar I., Siraganian R.P. The adapter molecule Gab2 regulates FcεRI-mediated signal transduction in mast cells. J. Immunol. 168:2002;4682-4691.
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J. Immunol.
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Xie, Z.H.1
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Siraganian, R.P.3
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37
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0037378588
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Gab3-deficient mice exhibit normal development and hematopoiesis and are immunocompetent
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Seiffert M., Custodio J.M., Wolf I., Harkey M., Liu Y., Blattman J.N., Greenberg P.D., Rohrschneider L.R. Gab3-deficient mice exhibit normal development and hematopoiesis and are immunocompetent. Mol. Cell. Biol. 23:2003;2415-2424.
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Mol. Cell. Biol.
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Seiffert, M.1
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Liu, Y.5
Blattman, J.N.6
Greenberg, P.D.7
Rohrschneider, L.R.8
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38
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0037255263
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Dok protein family members are involved in signaling mediated by the type 1 Fcε receptor
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Abramson J., Rozenblum G., Pecht I. Dok protein family members are involved in signaling mediated by the type 1 Fcε receptor. Eur. J. Immunol. 33:2003;85-91.
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Eur. J. Immunol.
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Abramson, J.1
Rozenblum, G.2
Pecht, I.3
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40
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0037105464
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Regulation of FcεRI-mediated degranulation by an adaptor protein 3BP2 in rat basophilic leukemia RBL-2H3 cells
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Sada K., Miah S.M.S., Maeno K., Kyo S., Qu X.J., Yamamura H. Regulation of FcεRI-mediated degranulation by an adaptor protein 3BP2 in rat basophilic leukemia RBL-2H3 cells. Blood. 100:2002;2138-2144.
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Blood
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Sada, K.1
Miah, S.M.S.2
Maeno, K.3
Kyo, S.4
Qu, X.J.5
Yamamura, H.6
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41
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0036521977
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Dissociation of the store-operated calcium current/(CRAC) and the Mg-nucleotide-regulated metal ion current MagNuM
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Hermosura M.C., Monteilh-Zoller M.K., Scharenberg A.M., Penner R., Fleig A. Dissociation of the store-operated calcium current/(CRAC) and the Mg-nucleotide-regulated metal ion current MagNuM. J. Physiol. 539:2002;445-458.
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J. Physiol.
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