In silico models for cellular and molecular immunology: Successes, promises and challenges

Nature Immunology

Volumn 4, Issue 10, 2003, Pages 933-936

  Chakraborty, Arup K ^a,b   Dustin, Michael L ^c   Shaw, Andrey S ^d  

^a University of California   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; I KAPPA B ALPHA; I KAPPA B BETA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; PROTEIN CDC42; T LYMPHOCYTE RECEPTOR;

ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNITY; BINDING KINETICS; CELL INTERACTION; CELL POLARITY; CELL SELECTION; CELLULAR IMMUNITY; COMPUTER MODEL; HELPER CELL; IMMUNOGENETICS; LYMPHOCYTE MIGRATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MATHEMATICAL MODEL; MOLECULAR BIOLOGY; OBSERVATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; THEORETICAL MODEL; THYMOCYTE;

ANIMALS; ANTIGEN PRESENTATION; CELL MOVEMENT; COMPUTER SIMULATION; IMMUNOLOGIC TECHNIQUES; MICE; MODELS, IMMUNOLOGICAL; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0142092630     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni1003-933     Document Type: Article

References (23)

1. Watson, J. & Crick, F. Nature 171, 737 (1953).
2. Burnet, F.M. The Clonal Selection Theory of Acquired Immunity (Vanderbilt Univ. Press, Nashville, 1959).
3. Billingham, R.E., Brent, L. & Medawar, P.B. Nature 172, 603-606 (1953).
4. Bretscher, P. & Cohn, M. Science 169, 1042 (1970).
5. Afferty, K.J. & Cunningham, A. Aust. J. Exp. Biol. Med. Sci. 53, 27-42 (1975).
6. Perelson, A.S. Nat. Rev. Immunol. 2, 28-36 (2002).
7. Vallitutti, S., Muller, S., Cella, M., Padovan, E. & Lanzavecchia, A. Nature 375, 148-151 (1995).
8. McKeithan, K. Proc. Natl. Acad. Sci. USA 92, 5042-5046 (1995).
9. Monks, C.R., Freiberg, B.A., Kupfer, H., Sciaky, N. & Kupfer, A. Nature 395, 82-86 (1998).
10. Grakoui, A. et al. Science 285, 221-227 (1999).
11. Ritchie, L.I. et al. Immunity 16, 595-606 (2002).
12. Lee, K.H. et al. Science 295, 1539-1542 (2002).
13. Hailman, E., Burack, W.R., Shaw, A.S., Dustin, M.L. & Allen, P.M. Immunity 16, 839-848 (2002).
14. Irvine, D.J., Purbhoo, M.A., Krogsgaard, M. & Davis, M.M. Nature 419, 845-849 (2002).
15. Coombs, D., Kalergis, A.M., Nathenson, S.G., Wofsy, C. & Goldstein, B. Nat. Immunol. 3, 926-931 (2002).
16. Qi, S.Y., Groves, J.T. & Chakraborty, A.K. Proc. Natl. Acad. Sci. USA 98, 6548-6553 (2001).
17. Lee, K. et al. Science, published online 25 September 2003 (doi:10.1126/Science.1086507).
18. Hoffmann, A., Levchenko, A., Scott, M.L. & Baltimore, D. Science 298, 1241-1245 (2002).
19. Miller, M.J., Wei, S.H., Cahalan, M.D. & Parker, I. Proc. Natl. Acad. Sci. USA 100, 2604-2609 (2003).
20. del Pozo, M.A. et al. Eur. J. Immunol. 29, 3609-3620 (1999).
21. Wedlich-Sodner, A. et al. Science 299, 1231-1235 (2003).
22. Stoll, S., Delon, J., Brotz, T.M. & Germain, R.N. Science 296, 1873-1876 (2002).
23. Bousso, P., Bhakta, N.R., Lewis, R.S. & Robey, E. Science 296, 1876-1880 (2002).