Abnormality of the DNA double-strand-break checkpoint/repair genes, ATM, BRCA1 and TP53, in breast cancer is related to tumour grade

British Journal of Cancer

Volumn 90, Issue 10, 2004, Pages 1995-2001

  Ding, S L ^a,b   Sheu, L F ^c   Yu, J C ^c   Yang, T L ^d   Chen, B F ^d   Leu, F J ^e   Shen, C Y ^b  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^c TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^d MACKAY MEMORIAL HOSPITAL   (Taiwan)

^e FU JEN CATHOLIC UNIVERSITY   (Taiwan)

Author keywords

ATM; BRCA1; Breast cancer; TP53

Indexed keywords

ATM PROTEIN; BRCA1 PROTEIN; DOUBLE STRANDED DNA; GENE PRODUCT; PROTEIN P53; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; PROTEIN SERINE THREONINE KINASE; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; ATM GENE; BREAST CANCER; CANCER GENETICS; CANCER GRADING; CELL DIFFERENTIATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DNA REPAIR; DNA STRAND BREAKAGE; FEMALE; GENE; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; GENETIC ANALYSIS; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MUTAGENIC ACTIVITY; ONCOGENE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TP53 GENE; TUMOR CELL; ADULT; BREAST TUMOR; CANCER STAGING; CELL TRANSFORMATION; DNA DAMAGE; GENE EXPRESSION REGULATION; GENETICS; HETEROZYGOSITY LOSS; IMMUNOHISTOCHEMISTRY; NUCLEOTIDE SEQUENCE; ONSET AGE; PAGET NIPPLE DISEASE; PATHOLOGY; POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE;

ADULT; AGE OF ONSET; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELL TRANSFORMATION, NEOPLASTIC; DNA DAMAGE; DNA MUTATIONAL ANALYSIS; DNA REPAIR; DNA-BINDING PROTEINS; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, BRCA1; GENES, P53; HUMANS; IMMUNOHISTOCHEMISTRY; LOSS OF HETEROZYGOSITY; NEOPLASM STAGING; POLYMERASE CHAIN REACTION; PROTEIN-SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEINS;

EID: 2942536701     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6601804     Document Type: Article

References (34)

1. Angèle S, Treilleux I, Tanière P, Martel-Planche G, Vuillaume M, Bailly C, Brémond A, Montesano R, Hall J (2000) Abnormal expression of the ATM and TP53 genes in sporadic breast carcinomas. Clin Cancer Res 6: 3536-3544
2. Balmain A (2002) Cancer as a complex genetic trait: tumor susceptibility in humans and mouse models. Cell 108: 145-152
3. Bay JO, Grancho M, Pernin D, Presneau N, Rio P, Tchirkov A, Uhrhammer N, Verrelle P, Gatti RA, Bignon YJ (1998) No evidence for constitutional ATM mutation in breast/gastric cancer families. Int J Oncol 12: 1385-1390
4. Bishop JM (1991) Molecular themes in oncogenesis. Cell 64: 235-248
5. Bogdani M, Teugels E, De Greve J, Bourgain C, Neyns B, Pipeleers-Marichal M (2002) Loss of nuclear BRCA1 localization in breast carcinoma is age dependent. Virchows Arch 440: 274-279
6. Buchholz TA, Weil MM, Story MD, Strom EA, Brock WA, McNeese MD (1999) Tumor suppressor genes and breast cancer. Radiat Oncol Investig 7: 55-65
7. Cressman VL, Backlund DC, Avrutskaya AV, Leadon SA, Godfrey V, Koller BH (1999) Growth retardation, DNA repair defects, and lack of spermatogenesis in BRCA1-deficient mice. Mol Cell Biol 19: 7061-7075
8. Dobrovic A, Simpfendorfer D (1997) Methylation of the BRCA1 gene in sporadic breast cancer. Cancer Res 57: 3347-3350
9. Finlay CA, Hinds PW, Tan TH, Eliyahu D, Oren M, Levine J (1988) Activating mutations for transformation by p53 produce a gene product that forms a hsc70-p53 complex with an altered half life. Mol Cell Biol 8: 531-539
10. Fu YP, Yu JC, Cheng TC, Lou MA, Hsu GC, Wu CY, Chen ST, Wu HS, Wu PE, Shen CY (2003) Breast cancer risk associated with genotypic polymorphism of the nonhomologous end-joining genes. Cancer Res 63: 2440-2446
11. Gatei M, Scott SP, Filippovitch I, Soronika N, Lavin MF, Weber B, Khanna KK (2000) Role for ATM in DNA damage-induced phosphorylation of BRCA1. Cancer Res 60: 3299-3304
12. Holt JT, Thompson ME, Szabo C, Robinson-Benion C, Artega CL, King MC, Jensen RA (1996) Growth retardation and tumor inhibition by BRCA1. Nat Genet 12: 298-302
13. Huang CS, Chern HD, Chang KJ, Cheng CW, Hsu SM, Shen CY (1999) Breast cancer risk associated with genotype polymorphism of the estrogen-metabolizing genes CYP17, CYP1A1, and COMT: a multigenic study on cancer susceptibility. Cancer Res 59: 4870-4875
14. Jones PA, Baylin SB (2002) The fundamental role of epigenetic events in cancer. Nat Rev Genet 3: 415-428
15. Jones PA, Laird PW (1999) Cancer epigenetics comes of age. Nat Genet 21: 163-167
16. Khanna KK, Jackson SP (2001) DNA double-strand breaks: signaling, repair and the cancer connection. Nat Genet 27: 247-254
17. Knudson Jr AG (1971) Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 68: 820-823
18. Kurose K, Gilley K, Matsumoto S, Watson PH, Zhou XP, Eng C (2002) Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas. Nat Genet 32: 355-357
19. Le Doussal V, Tubiana-Hulin M, Friedman S, Hacene K, Spyratos F, Brunet M (1989) Prognostic value of histologic grade nuclear components of Scarff-Bloom-Richardson (SBR). An improved score modification based on a multivariate analysis of 1262 invasive ductal breast carcinomas. Cancer 64: 1914-1921
20. Liao DJ, Du QQ, Yu BW, Grignon D, Sarkar FH (2003) Novel perspective: focusing on the X chromosome in reproductive cancers. Cancer Invest 21: 641-658
21. Lo YL, Yu JC, Huang CS, Tseng SL, Chang TM, Chang KJ, Wu CW, Shen CY (1998) Allelic loss of the BRCA1 and BRCA2 genes and other regions on 17q and 13q in breast cancer among women from Taiwan (area of low incidence but early onset). Int J Cancer 79: 580-587
22. Loeb KR, Loeb LA (2000) Significance of multiple mutations in cancer. Carcinogenesis 21: 379-385
23. Lou MA, Tseng SL, Chang SF, Yue CT, Chang BL, Chou CH, Yang SL, The BH, Wu CW, Shen CY (1997) Novel patterns of p53 abnormality in breast cancer from Taiwan: experience from a low incidence area. Br J Cancer 75: 746-751
24. Orr-Weaver TL, Weinberg RA (1998) A checkpoint on the road to cancer. Nature 392: 223-224
25. Papa S, Seripa D, Merla G, Gravina C, Giai M, Sismondi P, Rinaldi M, Serra A, Saglio G, Fazio VM (1998) Identification of a possible somatic BRCA1 mutation affecting translation efficiency in an early-onset sporadic breast cancer patient. J Natl Cancer Inst 90: 1011-1012
26. Rio PG, Pernin D, Bay JO, Albuisson E, Kwiatkowski F, De Latour M, Bernard-Gallon DJ, Bignon YJ (1998) Loss of heterozygosity of BRCA1, BRCA2 and ATM genes in sporadic invasive ductal breast carcinoma. Int J Oncol 13: 849-853
27. Shen CY, Yu IC, Lo YL, Kuo CH, Yue CT, Jou YS, Huang CS, Lung JC, Wu CW (2000) Genome-wide search for loss of heterozygosity using laser capture microdissected tissue of breast carcinoma: an implication for mutator phenotype and breast cancer pathogenesis. Cancer Res 60: 3884-3892
28. Vorechovsky I, Rasio D, Luo L, Monaco C, Hammarstrom L, Webster AD, Zaloudik J, Barbanti-Brodani G, James M, Russo G (1996) The ATM gene and susceptibility to breast cancer: analysis of 38 breast tumors reveals no evidence for mutation. Cancer Res 56: 2726-2732
29. Waha A, Sturne C, Kessler A, Koch A, Kreyer E, Fimmers R, Wiestler OD, Deimling AV, Krebs D, Schmutzler RK (1998) Expression of the ATM gene is significantly reduced in sporadic breast carcinomas. Int J Cancer 78: 306-309
30. Wang JY (2000) New link in a web of human genes. Nature 405: 404-405
31. Wilson CA, Ramos L, Villasenor MR, Anders KH, Press MF, Clarke K, Karlan B, Chen JJ, Scully R, Livingston D, Zuch RH, Kanter MH, Cohen S, Calzone FJ, Slamon DJ (1999) Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas. Nat Genet 21: 236-240
32. Xu X, Wagner KU, Larson D, Weaver Z, Li C, Ried T, Hennighausen L, Wynshaw -Boris A, Deng CX (1999) Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation. Nat Genet 22: 37-43
33. Yang PS, Yang TL, Liu CL, Wu CW, Shen CY (1997) A case-control study of breast cancer in Taiwan - a low-incidence area. Br J Cancer 75: 752-756
34. Yoshikawa K, Honda K, Inamoto T, Shinohara H, Yamauchi A, Suga K, Okuyama T, Shimada T, Kodama H, Noguchi S, Gazdar AF, Yamaoka Y, Takahashi R (1999) Reduction of BRCAl protein expression in Japanese sporadic breast carcinomas and its frequent loss in BRCA1-associated cases. Clin Cancer Res 5: 1249-1261