Polyglutamine-expanded ataxin-7 activates mitochondrial apoptotic pathway of cerebellar neurons by upregulating Bax and downregulating Bcl-xL

Cellular Signalling

Volumn 18, Issue 4, 2006, Pages 541-552

  Wang, Hung Li ^a   Yeh, Tu Hsueh ^a,b   Chou, An Hsun ^a,b   Kuo, Yu Li ^a   Luo, Li Jean ^a   He, Cai Ying ^a   Huang, Pei Chen ^a   Li, Allen H ^b  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Apoptosis; Ataxin 7; Cerebellum; Polyglutamine neurodegenerative disorders; Polyglutamine expanded ataxin 7; Spinocerebellar ataxia type 7

Indexed keywords

ATAXIN 7; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; MESSENGER RNA; MUTANT PROTEIN; POLYGLUTAMINE; PROTEIN BAX; PROTEIN BCL XL; PROTEIN SUBUNIT; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE;

APOPTOSIS; ARTICLE; BRAIN NERVE CELL; CEREBELLUM; CONTROLLED STUDY; DEGENERATIVE DISEASE; DOWN REGULATION; EMBRYO; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRION; MOLECULAR MECHANICS; MOLECULAR MODEL; NERVE CELL CULTURE; NERVE CELL NECROSIS; NICK END LABELING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPINOCEREBELLAR DEGENERATION; TISSUE CULTURE; UPREGULATION; VIRUS RECOMBINANT;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; CASPASE 3; CASPASE 9; CASPASES; CELLS, CULTURED; CEREBELLUM; CYTOCHROMES C; DOWN-REGULATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NERVE TISSUE PROTEINS; NEURONS; PEPTIDES; RATS; UP-REGULATION;

ATAXIA;

EID: 29044445801     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellsig.2005.05.024     Document Type: Article

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