Quantitative structure-activity relationship analysis of 2,3-diaryl indoles as selective cyclooxygenase-2 inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 20, Issue 5, 2005, Pages 455-461

  Prasanna, S ^a,b   Manivannan, E ^a   Chaturvedi, S C ^a  

^a DEVI AHILYA UNIVERSITY   (India)

^b UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

Cyclooxygenase 2 inhibitors; Diaryl indoles; Fujita Ban approach; Indomethacin modifications; Quantitative structure activity relationship (QSAR); Semi empirical AM1

Indexed keywords

2 PHENYL 3 SULFONYLPHENYLINDOLE DERIVATIVE; 2 SULFONYLPHENYL 3 PHENYLINDOLE DERIVATIVE; CYCLOOXYGENASE 2 INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG DESIGN; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; GEOMETRY; IC 50; IN VITRO STUDY; LINEAR REGRESSION ANALYSIS; MOUSE; MULTIPLE REGRESSION; NONHUMAN; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STATISTICAL SIGNIFICANCE;

CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; INDOLES; MOLECULAR STRUCTURE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

ANIMALIA;

EID: 28244470051     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360500277251     Document Type: Article

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