SCOPUS 정보 검색 플랫폼

Farmaco

Volumn 57, Issue 8, 2002, Pages 677-683

Synthesis and biological evaluation of N-substituted indole esters as inhibitors of cyclo-oxygenase-2 (COX-2)

(2) Olgen, Sureyya a Nebioglu, Dogu a

a ANKARA UNIVERSITY (Turkey)

Author keywords

1H NMR and mass spectra; COX 2 inhibitors; Indole carboxylic, acetic and propionic acids; Indole esters; N substitution

Indexed keywords

ACETIC ACID DERIVATIVE; BENZYL DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; DICYCLOHEXYLCARBODIIMIDE; DIMETHYLAMINOPYRIDINE; EG 1817; EG 1918; EG 2732; ESTER DERIVATIVE; INDOLE DERIVATIVE; INDOMETACIN; LM 4108; PROPIONIC ACID DERIVATIVE; PYRIDINE DERIVATIVE; ROFECOXIB; UNCLASSIFIED DRUG; CYCLOOXYGENASE 2; ESTER; ISOENZYME; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR;

ARTICLE; DRUG EFFECT; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; NONHUMAN; CHEMISTRY; COMPARATIVE STUDY; DRUG ANTAGONISM; METABOLISM; METHODOLOGY; SYNTHESIS;

COMPARATIVE STUDY; CYCLOOXYGENASE INHIBITORS; DRUG EVALUATION, PRECLINICAL; ESTERS; INDOLES; ISOENZYMES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE; SUPPORT, NON-U.S. GOV'T; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES;

EID: 0036689907 PISSN: 0014827X EISSN: None Source Type: Journal
DOI: 10.1016/S0014-827X(02)01233-8 Document Type: Article

Times cited : (21)

References (20)

1
- 0029975669
- Prostaglandin endoperoxide H synthases-1 and 2
- (1996) Adv. Immunol. , vol.62 , pp. 167-215
- Smith, W.L.¹ Dewitt, D.L.²

2
- 0033535606
- Synthesis, structure activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors 2. 1,3,4- and 1,2,4-thiadiazole series
- (1999) J. Med. Chem. , vol.42 , pp. 1161-1169
- Song, Y.¹ Connor, D.T.² Sercel, A.D.³ Sorenson, R.J.⁴ Doubleday, R.⁵ Unangst, P.C.⁶ Roth, B.D.⁷ Beylin, V.G.⁸ Gilbertsen, R.B.⁹ Chan, K.¹⁰ Schrier, D.J.¹¹ Guglietta, A.¹² Bornemeier, D.A.¹³ Dyer, R.D.¹⁴

3
- 0034030366
- N-[[(5-Methyl-3-phenylisoxazol-4-yl)-pheny]sulfonyl] propanamide, sodium salt, parecoxib sodium: A potent and selective inhibitor of COX-2 for parenteral administration
- (2000) J. Med. Chem. , vol.43 , pp. 1661-1663
- Talley, J.J.¹ Bertenshaw, S.R.² Brown, D.L.³ Carter, J.S.⁴ Graneto, M.J.⁵ Kellogg, M.S.⁶ Koboldt, C.M.⁷ Yuan, J.⁸ Zhang, Y.Y.⁹ Seibert, K.¹⁰

4
- 13444266910
- Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: Identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, celecoxib)
- (1997) J. Med. Chem. , vol.40 , pp. 1347-1365
- Penning, T.D.¹ Talley, J.J.² Bertenshaw, S.R.³ Carter, J.S.⁴ Collins, P.W.⁵ Docter, S.⁶ Graneto, M.J.⁷ Lee, L.F.⁸ Malecha, J.W.⁹ Miyashiro, J.M.¹⁰ Rogers, R.S.¹¹ Rogier, D.J.¹² Yu, S.S.¹³ Anderson, G.D.¹⁴ Burton, E.G.¹⁵ Cogburn, J.N.¹⁶ Gregory, S.A.¹⁷ Koboldt, C.M.¹⁸ Perkins, W.E.¹⁹ Seibert, K.²⁰ more..

5
- 0001650323
- Selective cyclooxygenase inhibitors
- (1995) Annu. Rep. Med. Chem. , vol.30 , pp. 179-186
- Reitz, D.B.¹ Seibert, K.²

6
- 0030029368
- Synthesis and biological evaluation of 2,3-diarylthiophenes as selective COX-2 inhibitors. Part II: Replacing the heterocycle
- (1996) Bioorg. Med. Chem. Lett. , vol.6 , pp. 87-92
- Gauthier, J.Y.¹ Lebranc, Y.² Black, W.C.³ Chan, C.-C.⁴ Cromlish, W.A.⁵ Gordon, R.⁶ Kennedey, B.P.⁷ Lau, C.K.⁸ Leger, S.⁹ Wang, Z.¹⁰ Ethier, D.¹¹ Guay, J.¹² Manchini, J.¹³ Riendeau, D.¹⁴ Tagari, P.¹⁵ Vickers, P.¹⁶ Wong, E.¹⁷ Xu, L.¹⁸ Prasit, P.¹⁹

7
- 0034624748
- 4-[5-Methyl-3-phenyisoxazol-4-yl]-benzenesulfonamide, valdecoxib: A potent and selective inhibitor of COX-2
- (2000) J. Med. Chem. , vol.43 , pp. 775-777
- Talley, J.J.¹ Brown, D.L.² Carter, J.S.³ Graneto, M.J.⁴ Koboldt, C.M.⁵ Masferrer, J.L.⁶ Perkins, W.E.⁷ Rogers, R.S.⁸ Shaffer, A.F.⁹ Zhang, Y.Y.¹⁰ Zweifel, B.S.¹¹ Siebert, K.¹²

8
- 0033583501
- Synthesis and activity of sulfonamide substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors
- (1999) Bioorg. Med. Chem. Lett. , vol.9 , pp. 1171-1174
- Carter, J.S.¹ Kramer, S.² Talley, J.J.³ Penning, T.⁴ Collins, P.⁵ Graneto, M.J.⁶ Seibert, K.⁷ Koboldt, C.M.⁸ Masferrer, J.⁹ Zweifel, B.¹⁰

9
- 0030919185
- 1,2-Diarylimidazoles as potent cyclooxygenase-2. Selective, and orally active antiinflammatory agents
- (1997) J. Med. Chem. , vol.40 , pp. 1634-1647
- Khanna, I.K.¹ Weier, R.M.² Yu, Y.³ Xu, X.D.⁴ Koszyk, F.J.⁵ Collins, P.W.⁶ Koboldt, C.M.⁷ Veenhuizen, A.W.⁸ Perkins, W.E.⁹ Casler, J.J.¹⁰ Masferrer, J.L.¹¹ Zhang, Y.Y.¹² Gregory, S.A.¹³ Seibert, K.¹⁴ Isakson, P.C.¹⁵

10
- 0027944191
- Selective cyclooxygenase inhibitors: Novel 1,2-diarylcyclopentenes are potent and orally active COX-2 inhibitors
- (1994) J. Med. Chem. , vol.37 , pp. 3878-3881
- Reitz, D.B.¹ Li, J.J.² Norton, M.B.³ Reinhard, E.J.⁴ Collins, J.T.⁵ Anderson, G.D.⁶ Gregory, S.A.⁷ Koboldt, C.M.⁸ Perkins, W.E.⁹ Seibert, K.¹⁰ Isakson, P.C.¹¹

11
- 0029981646
- From indomethacin to a selective COX-2 inhibitor: Development of indolalkanoic acids as potent and selective cyclooxygenase-2 inhibitors
- (1996) Bioorg. Med. Chem. Lett. , vol.6 , pp. 725-730
- Black, W.C.¹ Bayly, C.² Belley, M.³ Chan, C.-C.⁴ Charleson, S.⁵ Denis, D.⁶ Gauthier, J.Y.⁷ Gordon, R.⁸ Guay, D.⁹ Kargman, S.¹⁰ Lau, C.K.¹¹ Leblanc, Y.¹² Mancini, J.¹³ Ouellet, M.¹⁴ Percival, D.¹⁵ Roy, P.¹⁶ Skorey, K.¹⁷ Tagari, P.¹⁸ Vickers, P.¹⁹ Wong, E.²⁰ Xu, L.²¹ Prasit, P.²² more..

12
- 0034736019
- 1,3-Diaryl-4,5,6,7-tetrahydro-2H-isoindole derivatives: A new series of potent and selective COX-2 inhibitors in which a sulfonyl group is not a structural requisite
- (2000) J. Med. Chem. , vol.43 , pp. 4582-4593
- Portevin, B.¹ Tordjman, C.² Pastoureau, P.³ Bonnet, J.⁴ De Nanteuil, G.⁵

13
- 0034721194
- Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacine, as selective cyclooxygenase-2 inhibitors
- (2000) J. Med. Chem. , vol.43 , pp. 2860-2870
- Kalgutkar, A.S.¹ Marnett, A.B.² Crews, B.C.³ Remmel, R.P.⁴ Marnett, L.J.⁵

14
- 0034681109
- Biochemically based designed of cyclooxygenase (COX-2) inhibitors. Facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors
- (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 925-930
- Kalgutkar, A.S.¹ Crews, B.C.² Rowlinson, S.W.³ Marnett, A.B.⁴ Kozak, K.R.⁵ Remmel, R.P.⁶ Marnett, L.J.⁷

15
- 0036217907
- Syntheses and biological evaluation of indole-2 and 3-carboxamides: A new selective cyclooxygenase-2 inhibitors
- (2002) Die Pharmazie , vol.57 , pp. 238-241
- Ölgen, S.¹ Güner, E.² Crespo, M.I.³ Fabregat, A.M.⁴ Nebioǧlu, D.⁵

16
- 0025182574
- Preparation and proteolytic cleavage of apoprostaglandin endoperoxide synthase
- (1990) Methods Enzymol. , vol.187 , pp. 479-485
- Odenwaller, R.¹ Chen, Y.-N.P.² Marnett, L.J.³

17
- 0003593740
- New York: Wiley-Interscience
- (1972) Indoles, Parts I and II, The Chemistry of Heterocyclic Compounds
- Houlhian, W.J.¹

18
- 0035439443
- Synthesis and receptor docking studies of N-substituted indole-2-carboxylic acid esters as a search for selective enzyme inhibitors
- (2001) Eur. J. Med. Chem. , vol.36 , pp. 747-770
- Olgen, S.¹ Akaho, E.² Nebioǧlu, D.³

19
- 33748448195
- Synthetic methods. 12. Direct room temperature esterification of carboxylic acids
- (1978) Tetrahedron Lett. , vol.19 , pp. 4475-4478
- Hassner, A.¹ Alexanian, V.²

20
- 0021177272
- A novel method for the debenzylation of protected indole nitrogen
- (1984) Synthesis , pp. 738-740
- Murakami, Y.¹ Watanabe, T.² Kobayashi, A.³ Yokoyama, Y.⁴

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.