Thiazole analogues of the NSAID indomethacin as selective COX-2 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 10, 2001, Pages 1325-1328

  Woods, Keith W ^a   McCroskey, Richard W ^a   Michaelides, Michael R ^a   Wada, Carol K ^a   Hulkower, Keren I ^a   Bell, Randy L ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 BROMOBENZYLBROMIDE; BROMINE DERIVATIVE; CARBOXYL GROUP; CHLOROFORMIC ACID ISOBUTYL ESTER; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DIOXANE; FORMIC ACID DERIVATIVE; INDOLE; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT; THIAZOLE DERIVATIVE; TRIMETHYLSILYL DERIVATIVE; TRIMETHYLSILYLDIAZOMETHANE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; REACTION ANALYSIS;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; HUMANS; INDOMETHACIN; INHIBITORY CONCENTRATION 50; ISOENZYMES; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 0035927210     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00212-8     Document Type: Article

References (12)

1. Hawkey C.J. Lancet. 353:1999;307.
2. Masferrer J.L., Zweifel B.S., Manning P.T. Proc. Natl. Acad. Sci. U.S.A. 91:1994;3228.
3. Penning T.D., Talley J.J., Bertenshaw S.R., Carter J.S., Collins P.W., Docter S., Graneto M.J., Lee L.F., Malecha J.W., Miyashiro J.M., Rogers R.S., Rogier D.J., Yu S.S., Anderson G.D., Burton E.G., Cogburn J.N., Gregory S.A., Koboldt C.M., Perkins W.E., Seibert K., Veenhuizen A.W., Zhang Y.Y., Isakson P.C. J. Med. Chem. 40:1997;1347.
4. Prasit P., Wang Z., Brideau C., Chan C.-C., Charleson S., Cromlish W., Ethier D., Evans J.F., Ford-Hutchinson A.W., Gauthier J.Y., Gordon R., Guay J., Gresser M., Kargman S., Kennedy B., LeBlanc Y., Léger S., Mancini J., O'Neill G.P., Ouellet M., Percival M.D., Perrier H., Riendeau D., Rodger Y., Tagari P., Thérien M., Vickers P., Wong E., Xu L.-J., Young R.N., Zamboni R. Bioorg. Med. Chem. Lett. 9:1999;1773.
5. Goldstein J.L., Silverstein F.E., Agrawal N.M., Hubbard R.C., Kaiser J., Maurath C.J., Verburg K.M., Geis G.S. Am. J. Gastroenterol. 95:2000;1681.
6. Warner T.D., Giuliano F., Vojnovic I., Bukasa A., Mitchell J.A., Vane J.R. Proc. Natl. Acad. Sci. U.S.A. 96:1999;7563.
7. 6.
8. 2 produced was analyzed by enzyme linked immunoassay.
9. Kalgutkar A.S., Marnett A.B., Crews B.C., Remmel R.P., Marnett L.J. J. Med. Chem. 43:2000;2860.
10. Kalgutkar A.S., Crews B.C., Rowlinson S.W., Marnett A.B., Kozak K.R., Remmel R.P., Marnett L.J. Proc. Natl. Acad. Sci. U.S.A. 97:2000;925.
11. Black W.C., Bayly C., Belley M., Chan C.-C., Charleson S., Denis D., Gauthier J.Y., Gordon R., Guay D., Kargman S., Lau C.K., LeBlanc Y., Mancini J., Quellet M., Percival D., Roy P., Skorey K., Tagari P., Vickers P., Wong E., Xu L., Prasit P. Bioorg. Med. Chem. Lett. 6:1996;725.
12. LeBlanc Y., Black W.C., Chan C.-C., Charleson S., Delorme D., Denis D., Gauthier J.Y., Gordon R., Guay D., Hamel P., Kargman S., Lau C.K., Mancini J., Quellet M., Percival D., Roy P., Skorey K., Tagari P., Vickers P., Wong E., Xu L., Prasit P. Bioorg. Med. Chem. Lett. 6:1996;731.