Rational design of 6-methylsulfonylindoles as selective cyclooxygenase-2 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 18, 2004, Pages 4741-4745

  Campbell, Jeffrey A ^a,b   Bordunov, Viola ^a   Broka, Chris A ^a   Browner, Michelle F ^a   Kress, James M ^a   Mirzadegan, Tara ^a   Ramesha, Chakk ^a   Sanpablo, Bong F ^a   Stabler, Russell ^a   Takahara, Patricia ^a   Villasenor, Armando ^a   Walker, Keith A M ^a   Wang, Jin Hai ^a   Welch, Mary ^a   Weller, Paul ^a  

^a ROCHE BIOSCIENCE   (United States)

^b PTC THERAPEUTICS   (United States)

Author keywords

COX 2; Indole; Selective COX 2 inhibitor; X ray structure

Indexed keywords

CYCLOOXYGENASE 2 INHIBITOR; INDOLE DERIVATIVE;

ARTICLE; BLOOD; DRUG CONFORMATION; DRUG DESIGN; DRUG EFFECT; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; HYDROPHILICITY;

ADMINISTRATION, ORAL; ANIMALS; BINDING SITES; CARRAGEENAN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; HUMANS; INDOLES; INFLAMMATION; MEMBRANE PROTEINS; MODELS, MOLECULAR; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES;

EID: 8544247194     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.06.075     Document Type: Article

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