Preparation of 3-arylmethylindoles as selective COX-2 inhibitors

Tetrahedron Letters

Volumn 45, Issue 19, 2004, Pages 3793-3796

  Campbell, Jeffrey A ^a   Bordunov, Viola ^a   Broka, Chris A ^a   Dankwardt, John ^a   Hendricks, Robert T ^a   Kress, James M ^a   Walker, Keith A M ^a   Wang, Jin Hai ^a  

^a Roche Palo Alto ^*  (United States)

Author keywords

3 Arylmethylindole; 3 Benzylindole; COX 2 inhibitor; Palladium; Reductive indole alkylation; TMSOTf

Indexed keywords

BENZALDEHYDE DERIVATIVE; CYCLOOXYGENASE 2 INHIBITOR; INDOLE DERIVATIVE; KETONE; LEWIS ACID; METHYL GROUP; ORGANIC COMPOUND; PALLADIUM; SULFUR DERIVATIVE; ZINC;

ALKYLATION; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; METHYLATION; REDUCTION; STEREOCHEMISTRY;

EID: 1842850684     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.03.068     Document Type: Article

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12. +).
13. +).
14. - 327.
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16. 1H NMR.