Quantitative structure-activity relationship analysis of a series of 2,3-diaryl benzopyran analogues as novel selective cyclooxygenase-2 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 15, 2004, Pages 4005-4011

  Prasanna, S ^a   Manivannan, E ^a   Chaturvedi, S C ^a  

^a DEVI AHILYA UNIVERSITY   (India)

Author keywords

COX 1; COX 2; MOE; QSAR

Indexed keywords

BENZOPYRAN DERIVATIVE; CYCLOOXYGENASE 2 INHIBITOR;

ARTICLE; CORRELATION ANALYSIS; DRUG POTENCY; DRUG SYNTHESIS; PHYSICAL CHEMISTRY; PREDICTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

BENZOPYRANS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; HETEROCYCLIC COMPOUNDS; KINETICS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REGRESSION ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 3042600821     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.05.059     Document Type: Article

References (16)

1. Allison M.C., Howatson A.G., Torrance C.J., Lee F.D., Russell R.I. N. Engl. J. Med. 327:1992;749
2. Kujubu D.A., Fletcher B., Varnum B.C., Lim R.W., Herschman H.R. J. Biol. Chem. 266:1991;12866
3. Vane J.R., Mitchell J.A., Appleton I., Tomlinson A., Bishop-Bailey D., Croxtall J., Willoughby D.A. Proc. Natl. Acad. Sci. 91:1994;2046
4. Kurumbail R.G., Stevens A.M., Gierse J.K., McDonald J.J., Stegeman R.A., Pak J.Y., Gildehaus D., Miyashiro J.M., Penning T.D., Seibert K., Isakson P.C., Stallings W.C. Nature. 384:1996;644
5. Vane J.R. Nature. 367:1994;215
6. Prescott S.M., Fitzpattick F.A. Biochim. Biophys. Acta. 1470:2000;M69
7. Reddy B.S., Hirose Y., Lubet R., Steele V., Kelloff G., Paulson S., Seibert K., Rao C.V. Cancer Res. 60:2000;293
8. Kumar R., Singh P. Indian J. Chem. 36B:1997;1164
9. Singh P., Kumar R. J. Enzyme Inhib. 14:1999;277
10. Desiraju G.R., Gopalakrishnan B., Jetti R.K.R., Raveendra D., Sarma J.A.R.P., Subramanya H.S. Molecules. 5:2000;945
11. Chavatte P., Yous S., Marot C., Baurin N., Lesieur D. J. Med. Chem. 44:2001;3223
12. Roy K., Chakraborty S., Saha A. Bioorg. Med. Chem. 21:2003;3753
13. Garg R., Kurup A., Meakapati S.M., Hansch C. Chem. Rev. 103:2003;703
14. Joo Y.H., Kim J.K., Kang S.-H., Noh M.-S., Ha J.-Y., Choi J.K., Lim K.M., Lee C.H., Chung S. Bioorg. Med. Chem. Lett. 13:2003;413
15. Saxena A.K., Ram S., Saxena M., Singh N., Prathipati P., Jain P.C., Singh H.K., Anand N. Bioorg. Med. Chem. 11:2003;2085
16. Palomer A., Cabre F., Pascual J., Trujillo M.A., Entrena A., Gallo M.A., Garcia L., Mauleon D., Espinosa A. J. Med. Chem. 45:2002;1402