Rationalization of physico-chemical properties of 5, 6-diarylthiazolo [3,2-b]-1, 2, 4-triazoles towards cyclooxygenase-2 (COX-2) inhibition: A QSAR approach

Indian Journal of Biochemistry and Biophysics

Volumn 41, Issue 4, 2004, Pages 179-183

  Manivannan, E ^a   Prasanna, S ^a   Chaturvedi, S C ^a,b  

^a DEVI AHILYA UNIVERSITY   (India)

^b Rajiv Gandhi Proudyogiki Vishwavidyalaya   (India)

Author keywords

5, 6 diarylthiazolo 3, 2 b 1, 2, 4 triazoles; Calculated molar refractivity; Cyclooxygenase 2 (COX 2) enzyme; Dipole; Non steroidal anti inflammatory drugs; Principle moment of inertia X component (PMI X); Quantitative structure activity relationship

Indexed keywords

CYCLOOXYGENASE 2 INHIBITOR; TRIAZOLE DERIVATIVE;

ARTICLE; BINDING SITE; DIPOLE; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME INHIBITION; PHYSICAL CHEMISTRY; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANTI-INFLAMMATORY AGENTS; CATALYTIC DOMAIN; CHEMISTRY, PHARMACEUTICAL; CHEMISTRY, PHYSICAL; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DRUG DESIGN; ELECTROCHEMISTRY; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MODELS, THEORETICAL; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; TRIAZOLES;

EID: 10344222115     PISSN: 03011208     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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