Synthesis and receptor docking studies of N-substituted indole-2-carboxylic acid esters as a search for COX-2 selective enzyme inhibitors

European Journal of Medicinal Chemistry

Volumn 36, Issue 9, 2001, Pages 747-770

  Olgen, Sureyya ^a   Akaho, Eiichi ^b   Nebioglu, Dogu ^a  

^a ANKARA UNIVERSITY   (Turkey)

^b KOBE GAKUIN UNIVERSITY   (Japan)

Author keywords

COX 1 and COX 2 inhibition; COX 2 selectivity; Docking; Indole esters

Indexed keywords

2 INDOLECARBOXYLIC ACID; ALKYL GROUP; BENZENE DERIVATIVE; BENZYL DERIVATIVE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; ESTER DERIVATIVE; FLURBIPROFEN; INDOMETACIN; N H INDOLE 2 DIETHYLAMINOETHYLCARBOXYLIC ACID METHYL IODIDE; N PHENYLINDOLE 2 CARBOXYLIC ACID PIPERAZINE ESTER; PHENYL GROUP; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; IN VITRO STUDY; NONHUMAN; PREDICTION; STRUCTURE ACTIVITY RELATION;

EID: 0035439443     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(01)01258-2     Document Type: Article

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