A new synthesis of 3-arylthioindoles as selective COX-2 inhibitors using PIFA

Tetrahedron Letters

Volumn 45, Issue 21, 2004, Pages 4073-4075

  Campbell, Jeffrey A ^a   Broka, Chris A ^a   Gong, Leyi ^a   Walker, Keith A M ^a   Wang, Jin Hai ^a  

^a Roche Palo Alto ^*  (United States)

Author keywords

3 Arylthioindole; Benzenethiol; PIFA; Selective COX 2 inhibitors

Indexed keywords

CYCLOOXYGENASE 2 INHIBITOR; FLUOROACETIC ACID; INDOLE DERIVATIVE; METHYL GROUP; PHENYLIODINE BISTRIFLUOROACETATE; THIOPHENOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL PROCEDURES; DRUG SELECTIVITY; DRUG SYNTHESIS; ELECTRON; ELECTRONICS; REACTION ANALYSIS;

EID: 2342618963     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.03.153     Document Type: Article

References (18)

1. Hamel P., Girard Y. Chem. Ber. 96:1963;260
2. Browder C.C., Mitchell M.O., Smith R.L., Sulayman G.-E. Tetrahedron Lett. 34:1993;6245
3. Atkinson J.G., Hamel P., Girard Y. Synth. Commun. 6:1988;480
4. Matsugi M., Murata K., Nambu H., Kita Y. Tetrahedron Lett. 42:2001;1077
5. Matsugi M., Murata K., Gotanda K., Nambu H., Anilkumar G., Matsumoto K., Kita Y. J. Org. Chem. 66:2001;2434
6. Anzai K. J. Heterocycl. Chem. 16:1979;567
7. Raban M., Chern L.J. J. Org. Chem. 45:1980;1688
8. Jain S., Shukla A., Mukhopadhyay A., Suryawanshi S.N., Bhakuni D.S. Synth. Commun. 20:1990;1315
9. Kita Y., Takada T., Tohma H. Pure Appl. Chem. 68:1996;627
10. Pohnert G. J. fuer. Praktishe Chemie. 342:2000;731
11. Varvoglis A. Tetrahedron. 53:1997;1179
12. Moriarty R.M., Vaid R.K. Synthesis. 1990;431
13. Moriarty R.M., Ku Y.Y., Sultana M., Tuncay A. Tetrahedron Lett. 28:1987;431
14. Allais A. Eur. J. Med. Chem. Chim. Ther. 10:1975;187
15. Adams R.E., Press J.P., Deegan E.G. Synth. Commun. 12:1991;675
16. Semerth S. J. Heterocycl. Chem. 18:1981;1373
17. Broka, C. A.; Campbell, J. A. (F. Hoffmann-La Roche Ag, Switz.). PCT Int. Appl. WO 0329212, 2003, p 46
18. 2O: C, 50.02; H, 3.51; N, 3.43. Found: C, 50.01; H, 3.21; N, 3.49