Positive and negative allosteric modulation of metabotropic glutamate receptors: Emerging therapeutic potential

Pharmacology and Therapeutics

Volumn 104, Issue 3, 2004, Pages 233-244

  Kew, James N C ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

G protein coupled receptor; Metabotropic glutamate receptor; Negative allosteric modulator; Positive allosteric modulator

Indexed keywords

(9H XANTHENE 9 CARBONYL)CARBAMIC ACID BUTYL ESTER; 1 (3,4 DIHYDRO 2H PYRANO[2,3 B]QUINOLIN 7 YL) 2 PHENYL 1 ETHANONE; 1 ETHYL 2 METHYL 6 OXO 4 (1,2,4,5 TETRAHYDROBENZO[D]AZEPIN 3 YL) 1,6 DIHYDROPYRIMIDINE 5 CARBONITRILE; 2 (4 FLUOROPHENYL) 1 (TOLUENE 4 SULFONYL)PYRROLIDINE; 2 METHYL 6 (2 PHENYLVINYL)PYRIDINE; 2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 3 [(2 METHYL 4 THIAZOLYL)ETHYNYL]PYRIDINE; 3,3' DICHLOROBENZALDAZINE; 3,3' DIFLUOROBENZALDEHYDE; 3,3' DIMETHOXYBENZALDAZINE; 4 CARBOXY 3 HYDROXYPHENYLGLYCINE; 6 METHYL 2 PHENYLAZO 3 PYRIDINOL; 6A NAPHTHALEN 2 YLMETHYL 5 METHYLIDENEHEXAHYDROCYCLOPENTA[C]FURAN 1 ONE; 7 HYDROXYIMINOCYCLOPROPAN[B]CHROMEN 1ALPHA CARBOXYLIC ACID ETHYL ESTER; ANALGESIC AGENT; ANXIOLYTIC AGENT; BAY 36 7620; BENZALDEHYDE DERIVATIVE; BENZAMIDE DERIVATIVE; BENZODIAZEPINE; CARBAMIC ACID ESTER; DIPHENYLACETYLCARBAMIC ACID ETHYL ESTER; EGLUMETAD; GLUTAMATE RECEPTOR AGONIST; GLUTAMATE RECEPTOR ANTAGONIST; LY 487379; N [4 CHLORO 2 [(1,3 DIOXO 1,3 DIHYDRO 2H ISOINDOL 2 YL)METHYL]PHENYL] 2 HYDROXYBENZAMIDE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; PYRROLIDINE DERIVATIVE; QUINOLINE DERIVATIVE; R 214127; RO 01 6128; RO 67 4853; RO 67 6221; RO 67 7476; RO 71 8216; RO 71 8218; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALLOSTERISM; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANXIETY DISORDER; CENTRAL NERVOUS SYSTEM; CLINICAL TRIAL; COGNITIVE DEFECT; CONFORMATION; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG DEPENDENCE; DRUG EFFICACY; DRUG POTENCY; DRUG SAFETY; DRUG STRUCTURE; EPILEPSY; HUMAN; MENTAL DISEASE; NERVE CELL; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; PAIN; PANIC; PARKINSON DISEASE; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; REVIEW; SCHIZOPHRENIA;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; ANIMALS; CHEMISTRY, PHARMACEUTICAL; DRUG INDUSTRY; HUMANS; MOLECULAR SEQUENCE DATA; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 8844263762     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2004.08.010     Document Type: Review

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