N2-Benzyl-N1-(1-(1-naphthyl)ethyl)-3-phenylpropane-1, 2-diamines and conformationally restrained indole analogues: Development of calindol as a new calcimimetic acting at the calcium sensing receptor

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 12, 2004, Pages 3345-3349

  Kessler, Albane ^a   Faure, Hélène ^b   Petrel, Christophe ^b   Ruat, Martial ^b   Dauban, Philippe ^a   Dodd, Robert H ^a  

^a CNRS   (France)

^b LABORATOIRE DE NEUROBIOLOGIE CELLULAIRE ET MOLÉCULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 [N [1 (1 NAPHTHYL)ETHYL]AMINOMETHYL]INDOLE; CALCIMIMETIC AGENT; CALCIUM; CALINDOL; DIAMINE DERIVATIVE; INDOLE DERIVATIVE; INOSITOL PHOSPHATE; METHYL GROUP; N 2 (2 CHLOROBENZYL) N 1 [1 (1 NAPHTHYL)ETHYL] 3 PHENYLPROPANE 1,2 DIAMINE; N 2 (4 FLUOROBENZYL) N 1 [1 (1 NAPHTHYL)ETHYL] 3 PHENYLPROPANE 1,2 DIAMINE; NAPHTHYL GROUP; PHENYL GROUP; PROPANE; RECEPTOR; UNCLASSIFIED DRUG; CALCIUM SENSING RECEPTOR; DIAMINE; LIGAND;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHEMICAL INTERACTION; CHO CELL; CONFORMATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SYNTHESIS; NONHUMAN; STEREOCHEMISTRY; STIMULATION; SYNTHESIS; ANIMAL; CHEMISTRY; DOSE RESPONSE; HAMSTER; HUMAN; METABOLISM; MOLECULAR MIMICRY; RAT;

ANIMALS; CALCIUM; CHO CELLS; CRICETINAE; DIAMINES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INDOLES; LIGANDS; MOLECULAR CONFORMATION; MOLECULAR MIMICRY; RATS; RECEPTORS, CALCIUM-SENSING;

EID: 2442612684     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.03.056     Document Type: Article

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