Potent anti-R5 human immunodeficiency virus type 1 effects of a CCR5 antagonist, AK602/ONO4128/GW873140, in a novel human peripheral blood mononuclear cell nonobese diabetic-SCID, interleukin-2 receptor γ-chain-knocked-out AIDS mouse model

Journal of Virology

Volumn 79, Issue 4, 2005, Pages 2087-2096

  Nakata, Hirotomo ^a   Maeda, Kenji ^a   Miyakawa, Toshikazu ^a   Shibayama, Shiro ^b   Matsuo, Masayoshi ^b   Takaoka, Yoshikazu ^b   Ito, Mamoru ^c   Koyanagi, Yoshio ^d,f   Mitsuya, Hiroaki ^a,e  

^a KUMAMOTO UNIVERSITY   (Japan)

^b ONO PHARMACEUTICAL CO   (Japan)

^c CENTRAL INSTITUTE FOR EXPERIMENTAL ANIMALS   (Japan)

^d TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e NATIONAL CANCER INSTITUTE   (United States)

^f KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN P24; APLAVIROC; CD4 ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR5; INTERLEUKIN 2 RECEPTOR ALPHA; VIRUS DNA; VIRUS RNA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DIABETES MELLITUS; DISEASE MODEL; DISEASE PREDISPOSITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION SENSITIVITY; KNOCKOUT MOUSE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCID MOUSE; VIRUS INFECTIVITY; VIRUS REPLICATION;

ANIMALS; ANTI-HIV AGENTS; CD4-CD8 RATIO; DISEASE MODELS, ANIMAL; HIV INFECTIONS; HIV-1; HUMANS; LEUKOCYTES, MONONUCLEAR; MICE; MICE, SCID; PIPERAZINES; RECEPTORS, CCR5; SPIRO COMPOUNDS;

ANIMALIA; DNA VIRUSES; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 13444259411     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.79.4.2087-2096.2005     Document Type: Article

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