메뉴 건너뛰기




Volumn 12, Issue , 2005, Pages S118-S130

Genetic modification of hematopoietic stem cells with nonviral systems: Past progress and future prospects

Author keywords

Electroporation; Episomes; Gene transfer; Hematopoietic stem cells; Nonviral vectors

Indexed keywords

CATION; DNA; LIPID; MULTIDRUG RESISTANCE PROTEIN 1; PLASMID DNA; POLYMER; RETROVIRUS VECTOR;

EID: 27544501923     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/sj.gt.3302626     Document Type: Article
Times cited : (59)

References (193)
  • 1
    • 0034631356 scopus 로고    scopus 로고
    • Gene therapy using hematopoietic stem cells: Sisyphus approaches the crest
    • Halene S, Kohn DB. Gene therapy using hematopoietic stem cells: sisyphus approaches the crest. Hum Gene Ther 2000; 11: 1259-1267.
    • (2000) Hum Gene Ther , vol.11 , pp. 1259-1267
    • Halene, S.1    Kohn, D.B.2
  • 2
    • 0035065951 scopus 로고    scopus 로고
    • Gene therapy: Principles and applications to hematopoietic cells
    • Van Tendeloo VF, Van Broeckhoven C, Berneman ZN. Gene therapy: principles and applications to hematopoietic cells. Leukemia 2001; 15: 523-544.
    • (2001) Leukemia , vol.15 , pp. 523-544
    • Van Tendeloo, V.F.1    Van Broeckhoven, C.2    Berneman, Z.N.3
  • 3
    • 0034303586 scopus 로고    scopus 로고
    • Diversification of hematopoietic stem cells to specific lineages
    • Orkin SH. Diversification of hematopoietic stem cells to specific lineages. Nat Rev Genet 2000; 1: 57-64.
    • (2000) Nat Rev Genet , vol.1 , pp. 57-64
    • Orkin, S.H.1
  • 4
    • 0035182533 scopus 로고    scopus 로고
    • Stem and progenitor cells: Origins, phenotypes, lineage commitments, and transdifferentiations
    • Weissman IL, Anderson DJ, Gage F. Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. Annu Rev Cell Dev Biol 2001; 17: 387-403.
    • (2001) Annu Rev Cell Dev Biol , vol.17 , pp. 387-403
    • Weissman, I.L.1    Erson, D.J.2    Gage, F.3
  • 5
    • 0028789792 scopus 로고
    • Gene therapy in peripheral blood lymphocytes and bone marrow for ADA-immunodeficient patients
    • Bordignon C et al. Gene therapy in peripheral blood lymphocytes and bone marrow for ADA-immunodeficient patients. Science 1995; 270: 470-475.
    • (1995) Science , vol.270 , pp. 470-475
    • Bordignon, C.1
  • 6
    • 0035731762 scopus 로고    scopus 로고
    • Gene transfer and the treatment of haematological malignancy
    • Brenner MK. Gene transfer and the treatment of haematological malignancy. J Intern Med 2001; 249: 345-358.
    • (2001) J Intern Med , vol.249 , pp. 345-358
    • Brenner, M.K.1
  • 7
    • 0035731827 scopus 로고    scopus 로고
    • Gene therapy for genetic haematological disorders and immunodeficiencies
    • Kohn DB. Gene therapy for genetic haematological disorders and immunodeficiencies. J Intern Med 2001; 249: 379-390.
    • (2001) J Intern Med , vol.249 , pp. 379-390
    • Kohn, D.B.1
  • 9
    • 1942473901 scopus 로고    scopus 로고
    • Gene therapy for inherited disorders of haematopoietic cells
    • Klein C, Baum C. Gene therapy for inherited disorders of haematopoietic cells. Hematol J 2004; 5: 103-111.
    • (2004) Hematol J , vol.5 , pp. 103-111
    • Klein, C.1    Baum, C.2
  • 10
    • 0036230462 scopus 로고    scopus 로고
    • Therapeutic applications for hematopoietic stem cell gene transfer
    • Bordignon C, Roncarolo MG. Therapeutic applications for hematopoietic stem cell gene transfer. Nat Immunol 2002; 3: 318-321.
    • (2002) Nat Immunol , vol.3 , pp. 318-321
    • Bordignon, C.1    Roncarolo, M.G.2
  • 11
    • 10744233858 scopus 로고    scopus 로고
    • American Society of Gene Therapy (ASGT) ad hoc subcommittee on retroviral-mediated gene transfer to hematopoietic stem cells
    • Kohn DB et al. American Society of Gene Therapy (ASGT) ad hoc subcommittee on retroviral-mediated gene transfer to hematopoietic stem cells. Mol Ther 2003; 8: 180-187.
    • (2003) Mol Ther , vol.8 , pp. 180-187
    • Kohn, D.B.1
  • 12
    • 3342878376 scopus 로고    scopus 로고
    • Prospects and implications of using chromatin insulators in gene therapy and transgenesis
    • Recillas-Targa F, Valadez-Graham V, Farrell CM. Prospects and implications of using chromatin insulators in gene therapy and transgenesis. BioEssays 2004; 26: 796-807.
    • (2004) Bioessays , vol.26 , pp. 796-807
    • Recillas-Targa, F.1    Valadez-Graham, V.2    Farrell, C.M.3
  • 13
    • 0035342360 scopus 로고    scopus 로고
    • Progress toward vector design for hematopoietic stem cell gene therapy
    • Hawley RG. Progress toward vector design for hematopoietic stem cell gene therapy. Curr Gene Ther 2001; 1: 1-17.
    • (2001) Curr Gene Ther , vol.1 , pp. 1-17
    • Hawley, R.G.1
  • 14
    • 0037443457 scopus 로고    scopus 로고
    • Side effects of retroviral gene transfer into hematopoietic stem cells
    • Baum C et al. Side effects of retroviral gene transfer into hematopoietic stem cells. Blood 2003; 101: 2099-2114.
    • (2003) Blood , vol.101 , pp. 2099-2114
    • Baum, C.1
  • 15
    • 4444245489 scopus 로고    scopus 로고
    • Safety concerns related to hematopoietic stem cell gene transfer using retroviral vectors
    • Haviernik P, Bunting KD. Safety concerns related to hematopoietic stem cell gene transfer using retroviral vectors. Curr Gene Ther 2004; 4: 263-276.
    • (2004) Curr Gene Ther , vol.4 , pp. 263-276
    • Haviernik, P.1    Bunting, K.D.2
  • 16
    • 0031743608 scopus 로고    scopus 로고
    • Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery
    • Zufferey R et al. Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery. J Virol 1998; 72: 9873-9880.
    • (1998) J Virol , vol.72 , pp. 9873-9880
    • Zufferey, R.1
  • 17
    • 0037424875 scopus 로고    scopus 로고
    • Current developments in the design of onco-retrovirus and lentivirus vector systems for hematopoietic cell gene therapy
    • Brenner S, Malech HL. Current developments in the design of onco-retrovirus and lentivirus vector systems for hematopoietic cell gene therapy. Biochim Biophys Acta 2003; 1640: 1-24.
    • (2003) Biochim Biophys Acta , vol.1640 , pp. 1-24
    • Brenner, S.1    Malech, H.L.2
  • 18
    • 0142089747 scopus 로고    scopus 로고
    • Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer
    • Raper SE et al. Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer. Mol Genet Metab 2003; 80: 148-158.
    • (2003) Mol Genet Metab , vol.80 , pp. 148-158
    • Raper, S.E.1
  • 19
    • 0036222982 scopus 로고    scopus 로고
    • Improvements in gene therapy: Averting the immune response to adenoviral vectors
    • Ritter T, Lehmann M, Volk HD. Improvements in gene therapy: averting the immune response to adenoviral vectors. BioDrugs 2002; 16: 3-10.
    • (2002) Biodrugs , vol.16 , pp. 3-10
    • Ritter, T.1    Lehmann, M.2    Volk, H.D.3
  • 20
    • 0142084745 scopus 로고    scopus 로고
    • LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
    • Hacein-Bey-Abina S et al. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 2003; 302: 415-419.
    • (2003) Science , vol.302 , pp. 415-419
    • Hacein-Bey-Abina, S.1
  • 21
    • 0037235453 scopus 로고    scopus 로고
    • Retroviral insertional mutagenesis: Tagging cancer pathways
    • Mikkers H, Berns A. Retroviral insertional mutagenesis: tagging cancer pathways. Adv Cancer Res 2003; 88: 53-99.
    • (2003) Adv Cancer Res , vol.88 , pp. 53-99
    • Mikkers, H.1    Berns, A.2
  • 22
    • 10744233606 scopus 로고    scopus 로고
    • Chance or necessity? Insertional mutagenesis in gene therapy and its consequences
    • Baum C et al. Chance or necessity? Insertional mutagenesis in gene therapy and its consequences. Mol Ther 2004; 9: 5-13.
    • (2004) Mol Ther , vol.9 , pp. 5-13
    • Baum, C.1
  • 23
    • 0037134031 scopus 로고    scopus 로고
    • Murine leukemia induced by retroviral gene marking
    • Li Z et al. Murine leukemia induced by retroviral gene marking. Science 2002; 296: 497.
    • (2002) Science , vol.296 , pp. 497
    • Li, Z.1
  • 24
    • 0028230779 scopus 로고
    • Lack of expression from a retroviral vector after transduction of murine hematopoietic stem cells is associated with methylation in vivo
    • Challita PM, Kohn DB. Lack of expression from a retroviral vector after transduction of murine hematopoietic stem cells is associated with methylation in vivo. Proc Natl Acad Sci USA 1994; 91: 2567-2571.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 2567-2571
    • Challita, P.M.1    Kohn, D.B.2
  • 26
    • 0034329445 scopus 로고    scopus 로고
    • Retrovirus vector silencing is de novo methylase independent and marked by a repressive histone code
    • Pannell D et al. Retrovirus vector silencing is de novo methylase independent and marked by a repressive histone code. EMBO J 2000; 19: 5884-5894.
    • (2000) EMBO J , vol.19 , pp. 5884-5894
    • Pannell, D.1
  • 27
    • 0030811938 scopus 로고    scopus 로고
    • Integration of foreign DNA and its consequences in mammalian systems
    • Doerfler W et al. Integration of foreign DNA and its consequences in mammalian systems. Trends Biotechnol 1997; 15: 297-301.
    • (1997) Trends Biotechnol , vol.15 , pp. 297-301
    • Doerfler, W.1
  • 28
    • 0025976935 scopus 로고
    • Genetically modified skin fibroblasts persist long after transplantation but gradually inactivate introduced genes
    • Palmer TD, Rosman GJ, Osborne WR, Miller AD. Genetically modified skin fibroblasts persist long after transplantation but gradually inactivate introduced genes. Proc Natl Acad Sci USA 1991; 88: 1330-1334.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 1330-1334
    • Palmer, T.D.1    Rosman, G.J.2    Osborne, W.R.3    Miller, A.D.4
  • 29
    • 0026098571 scopus 로고
    • Inactivation of the Moloney murine leukemia virus long terminal repeat in murine fibroblast lines is associated with methylation and dependent on its chromosomal position
    • Hoeben RC et al. Inactivation of the Moloney murine leukemia virus long terminal repeat in murine fibroblast lines is associated with methylation and dependent on its chromosomal position. J Virol 1991; 65: 904-912.
    • (1991) J Virol , vol.65 , pp. 904-912
    • Hoeben, R.C.1
  • 30
    • 0028286165 scopus 로고
    • Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila
    • Dorer DR, Henikoff S. Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila. Cell 1994; 77: 993-1002.
    • (1994) Cell , vol.77 , pp. 993-1002
    • Dorer, D.R.1    Henikoff, S.2
  • 31
    • 0030747760 scopus 로고    scopus 로고
    • Cosuppression comes to the animals
    • Bingham PM. Cosuppression comes to the animals. Cell 1997; 90: 385-387.
    • (1997) Cell , vol.90 , pp. 385-387
    • Bingham, P.M.1
  • 32
    • 0025279872 scopus 로고
    • Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection
    • Miller DG, Adam MA, Miller AD. Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection. Mol Cell Biol 1990; 10: 4239-4242.
    • (1990) Mol Cell Biol , vol.10 , pp. 4239-4242
    • Miller, D.G.1    Adam, M.A.2    Miller, A.D.3
  • 33
    • 16144365969 scopus 로고    scopus 로고
    • Identification of primitive human hematopoietic cells capable of repopulating NODlSCID mouse bone marrow: Implications for gene therapy
    • Larochelle A et al. Identification of primitive human hematopoietic cells capable of repopulating NODlSCID mouse bone marrow: implications for gene therapy. Nat Med 1996; 2: 1329-1337.
    • (1996) Nat Med , vol.2 , pp. 1329-1337
    • Larochelle, A.1
  • 34
    • 0029055941 scopus 로고
    • Analysis of optimal conditions for retroviral-mediated transduction of primitive human hematopoietic cells
    • Nolta JA, Smogorzecwska EM, Kohn DB. Analysis of optimal conditions for retroviral-mediated transduction of primitive human hematopoietic cells. Blood 1995; 86: 101-110.
    • (1995) Blood , vol.86 , pp. 101-110
    • Nolta, J.A.1    Smogorzecwska, E.M.2    Kohn, D.B.3
  • 35
    • 0032529523 scopus 로고    scopus 로고
    • Ex vivo expansion of genetically marked rhesus peripheral blood progenitor cells results in diminished longterm repopulating ability
    • Tisdale JF et al. Ex vivo expansion of genetically marked rhesus peripheral blood progenitor cells results in diminished longterm repopulating ability. Blood 1998; 92: 1131-1141.
    • (1998) Blood , vol.92 , pp. 1131-1141
    • Tisdale, J.F.1
  • 36
    • 0027233837 scopus 로고
    • Ex vivo expansion of hematopoietic stem and progenitor cells: Robbing Peter to pay Paul?
    • Williams DA. Ex vivo expansion of hematopoietic stem and progenitor cells: robbing Peter to pay Paul? Blood 1993; 81: 3169-3172.
    • (1993) Blood , vol.81 , pp. 3169-3172
    • Williams, D.A.1
  • 37
    • 0036811540 scopus 로고    scopus 로고
    • Advances in lentiviral vector design for gene-modification of hematopoietic stem cells
    • Logan AC, Lutzko C, Kohn DB. Advances in lentiviral vector design for gene-modification of hematopoietic stem cells. Curr Opin Biotechnol 2002; 13: 429-436.
    • (2002) Curr Opin Biotechnol , vol.13 , pp. 429-436
    • Logan, A.C.1    Lutzko, C.2    Kohn, D.B.3
  • 38
    • 0036512761 scopus 로고    scopus 로고
    • Nonviral approaches satisfying various requirements for effective in vivo gene therapy
    • Nishikawa M, Hashida M. Nonviral approaches satisfying various requirements for effective in vivo gene therapy. Biol Pharm Bull 2002; 25: 275-283.
    • (2002) Biol Pharm Bull , vol.25 , pp. 275-283
    • Nishikawa, M.1    Hashida, M.2
  • 39
    • 0036954247 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: Nonviral vectors
    • Niidome T, Huang L. Gene therapy progress and prospects: nonviral vectors. Gene Therapy 2002; 9: 1647-1652.
    • (2002) Gene Therapy , vol.9 , pp. 1647-1652
    • Niidome, T.1    Huang, L.2
  • 40
    • 0030906499 scopus 로고    scopus 로고
    • Emerging applications of gene transfer in the hematopoietic cancers
    • Brenner MK. Emerging applications of gene transfer in the hematopoietic cancers. J Pediatr Hemat Oncol 1997; 19: 1-6.
    • (1997) J Pediatr Hemat Oncol , vol.19 , pp. 1-6
    • Brenner, M.K.1
  • 41
    • 0038143157 scopus 로고    scopus 로고
    • Cationic transfection lipids in gene therapy: Successes, set-backs, challenges and promises
    • Kumar VV, Singh RS, Chaudhuri A. Cationic transfection lipids in gene therapy: successes, set-backs, challenges and promises. Curr Med Chem 2003; 10: 1297-1306.
    • (2003) Curr Med Chem , vol.10 , pp. 1297-1306
    • Kumar, V.V.1    Singh, R.S.2    Chaudhuri, A.3
  • 42
    • 0032965398 scopus 로고    scopus 로고
    • Cationic lipid-mediated gene transfer: Current concepts
    • Clark PR, Hersh EM. Cationic lipid-mediated gene transfer: current concepts. Curr Opin Mol Ther 1999; 1: 158-176.
    • (1999) Curr Opin Mol Ther , vol.1 , pp. 158-176
    • Clark, P.R.1    Hersh, E.M.2
  • 43
    • 0029558004 scopus 로고
    • Cationic liposome-mediated gene transfer
    • Gao X, Huang L. Cationic liposome-mediated gene transfer. Gene Therapy 1995; 2: 710-722.
    • (1995) Gene Therapy , vol.2 , pp. 710-722
    • Gao, X.1    Huang, L.2
  • 45
    • 0028097638 scopus 로고
    • DNA transfection mediated by cationic liposomes containing lipopolylysine: Characterization and mechanism of action
    • Zhou X, Huang L. DNA transfection mediated by cationic liposomes containing lipopolylysine: characterization and mechanism of action. Biochim Biophys Acta 1994; 1189: 195-203.
    • (1994) Biochim Biophys Acta , vol.1189 , pp. 195-203
    • Zhou, X.1    Huang, L.2
  • 46
    • 0030071910 scopus 로고    scopus 로고
    • Endocytosis and intracellular processing accompanying transfection mediated by cationic liposomes
    • Friend DS, Papahadjopoulos D, Debs RJ. Endocytosis and intracellular processing accompanying transfection mediated by cationic liposomes. Biochim Biophys Acta 1996; 1278: 41-50.
    • (1996) Biochim Biophys Acta , vol.1278 , pp. 41-50
    • Friend, D.S.1    Papahadjopoulos, D.2    Debs, R.J.3
  • 47
    • 0029056088 scopus 로고
    • Cellular and molecular barriers to gene transfer by a cationic lipid
    • Zabner J et al. Cellular and molecular barriers to gene transfer by a cationic lipid. J Biol Chem 1995; 270: 18997-19007.
    • (1995) J Biol Chem , vol.270 , pp. 18997-19007
    • Zabner, J.1
  • 48
    • 0002947302 scopus 로고
    • Lipofectamine reagent: A new, higher efficiency polycationic liposome transfection reagent
    • Hawley-Nelson P et al. Lipofectamine reagent: a new, higher efficiency polycationic liposome transfection reagent. Focus 1993; 15: 73-79.
    • (1993) Focus , vol.15 , pp. 73-79
    • Hawley-Nelson, P.1
  • 49
    • 0035876601 scopus 로고    scopus 로고
    • An efficient gene transfer system for hematopoietic cell line using transient and stable vectors
    • Teixeira LA et al. An efficient gene transfer system for hematopoietic cell line using transient and stable vectors. J Biotechnol 2001; 88: 159-165.
    • (2001) J Biotechnol , vol.88 , pp. 159-165
    • Teixeira, L.A.1
  • 50
    • 0036431478 scopus 로고    scopus 로고
    • Cationic lipids in gene delivery: Principles, vector design and therapeutic applications
    • Ilies MA, Seitz WA, Balaban AT. Cationic lipids in gene delivery: principles, vector design and therapeutic applications. Curr Pharm Des 2002; 8: 2441-2473.
    • (2002) Curr Pharm Des , vol.8 , pp. 2441-2473
    • Ilies, M.A.1    Seitz, W.A.2    Balaban, A.T.3
  • 51
    • 0033924663 scopus 로고    scopus 로고
    • Repeat administration of DNAlliposomes to the nasal epithelium of patients with cystic fibrosis
    • Hyde SC et al. Repeat administration of DNAlliposomes to the nasal epithelium of patients with cystic fibrosis. Gene Therapy 2000; 7: 1156-1165.
    • (2000) Gene Therapy , vol.7 , pp. 1156-1165
    • Hyde, S.C.1
  • 52
    • 0030798821 scopus 로고    scopus 로고
    • Cationic phosphonolipids as non viral vectors for DNA transfection in hematopoietic cell lines and CD34+ cells
    • Floch V et al. Cationic phosphonolipids as non viral vectors for DNA transfection in hematopoietic cell lines and CD34+ cells. Blood Cell Mol Dis 1997; 23: 69-87.
    • (1997) Blood Cell Mol Dis , vol.23 , pp. 69-87
    • Floch, V.1
  • 53
    • 0028828598 scopus 로고
    • Optimization of gene transfer using cationic lipids in cell lines and primary human CD4+ and CD34+ hematopoietic cells
    • Harrison GS et al. Optimization of gene transfer using cationic lipids in cell lines and primary human CD4+ and CD34+ hematopoietic cells. Biotechniques 1995; 19: 816-823.
    • (1995) Biotechniques , vol.19 , pp. 816-823
    • Harrison, G.S.1
  • 54
    • 0031590281 scopus 로고    scopus 로고
    • Efficient gene transduction by Epstein-Barr virus- based vectors coupled with cationic liposome and HVJ- liposome
    • Satoh E et al. Efficient gene transduction by Epstein-Barr virus- based vectors coupled with cationic liposome and HVJ- liposome. Biochem Biophys Res Commun 1997; 238: 795-799.
    • (1997) Biochem Biophys Res Commun , vol.238 , pp. 795-799
    • Satoh, E.1
  • 55
    • 0029857893 scopus 로고    scopus 로고
    • An electron microscopy study into the mechanism of gene transfer with lipopolyamines
    • Labat-Moleur F et al. An electron microscopy study into the mechanism of gene transfer with lipopolyamines. Gene Therapy 1996; 3: 1010-1017.
    • (1996) Gene Therapy , vol.3 , pp. 1010-1017
    • Labat-Moleur, F.1
  • 56
    • 0030462391 scopus 로고    scopus 로고
    • Optimized galenics improve in vitro gene transfer with cationic molecules up to 1000-fold
    • Boussif O, Zanta MA, Behr JP. Optimized galenics improve in vitro gene transfer with cationic molecules up to 1000-fold. Gene Therapy 1996; 3: 1074-1080.
    • (1996) Gene Therapy , vol.3 , pp. 1074-1080
    • Boussif, O.1    Zanta, M.A.2    Behr, J.P.3
  • 57
    • 0033965863 scopus 로고    scopus 로고
    • Increased liposome-mediated gene transfer into hematopoietic cells grown in adhesion to stromal or fibroblast cell line monolayers
    • Marit G et al. Increased liposome-mediated gene transfer into hematopoietic cells grown in adhesion to stromal or fibroblast cell line monolayers. Eur J Haematol 2000; 64: 22-31.
    • (2000) Eur J Haematol , vol.64 , pp. 22-31
    • Marit, G.1
  • 58
    • 0032981203 scopus 로고    scopus 로고
    • Transgene expression, but not gene delivery, is improved by adhesion-assisted lipofection of hematopoietic cells
    • Keller H et al. Transgene expression, but not gene delivery, is improved by adhesion-assisted lipofection of hematopoietic cells. Gene Therapy 1999; 6: 931-938.
    • (1999) Gene Therapy , vol.6 , pp. 931-938
    • Keller, H.1
  • 59
    • 0032557206 scopus 로고    scopus 로고
    • Transgene expression kinetics after transfection with cationic phosphonolipids in hematopoietic non adherent cells
    • Floch V et al. Transgene expression kinetics after transfection with cationic phosphonolipids in hematopoietic non adherent cells. Biochim Biophys Acta 1998; 1371: 53-70.
    • (1998) Biochim Biophys Acta , vol.1371 , pp. 53-70
    • Floch, V.1
  • 60
    • 0034059514 scopus 로고    scopus 로고
    • Cell cycle dependence of gene transfer by lipoplex, polyplex and recombinant adenovirus
    • Brunner S et al. Cell cycle dependence of gene transfer by lipoplex, polyplex and recombinant adenovirus. Gene Therapy 2000; 7: 401-407.
    • (2000) Gene Therapy , vol.7 , pp. 401-407
    • Brunner, S.1
  • 61
    • 0025600919 scopus 로고
    • In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment
    • Yang NS et al. In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment. Proc Natl Acad Sci USA 1990; 87: 9568-9572.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 9568-9572
    • Yang, N.S.1
  • 62
    • 0029941315 scopus 로고    scopus 로고
    • Successful biolistic transformation of mouse pancreatic islets while preserving cellular function
    • Gainer AL et al. Successful biolistic transformation of mouse pancreatic islets while preserving cellular function. Trasplanta- tion 1996; 61: 1567-1571.
    • (1996) Trasplanta- Tion , vol.61 , pp. 1567-1571
    • Gainer, A.L.1
  • 63
    • 0031698168 scopus 로고    scopus 로고
    • Transient transfection of primary T helper cells by particle-mediated gene transfer
    • Huang H, Pannetier C, Hu-Li J, Paul WE. Transient transfection of primary T helper cells by particle-mediated gene transfer. J Immunol Methods 1998; 215: 173-177.
    • (1998) J Immunol Methods , vol.215 , pp. 173-177
    • Huang, H.1    Pannetier, C.2    Hu-Li, J.3    Paul, W.E.4
  • 64
    • 0032505706 scopus 로고    scopus 로고
    • Cytokine transgene expression and promoter usage in primary CD34+ cells using particle-mediated gene delivery
    • Ye ZQ et al. Cytokine transgene expression and promoter usage in primary CD34+ cells using particle-mediated gene delivery. Hum Gene Ther 1998; 9: 2197-2205.
    • (1998) Hum Gene Ther , vol.9 , pp. 2197-2205
    • Ye, Z.Q.1
  • 65
    • 0031860768 scopus 로고    scopus 로고
    • Gene transfer into human umbilical cord blood- derived CD34+ cells by particle-mediated gene transfer
    • Verma S et al. Gene transfer into human umbilical cord blood- derived CD34+ cells by particle-mediated gene transfer. Gene Therapy 1998; 5: 692-699.
    • (1998) Gene Therapy , vol.5 , pp. 692-699
    • Verma, S.1
  • 66
    • 0025313081 scopus 로고
    • Changes in membrane structure induced by electroporation as revealed by rapid-freezing electron microscopy
    • Chang DC, Reese TS. Changes in membrane structure induced by electroporation as revealed by rapid-freezing electron microscopy. Biophys J 1990; 58: 1-12.
    • (1990) Biophys J , vol.58 , pp. 1-12
    • Chang, D.C.1    Reese, T.S.2
  • 67
    • 0028343363 scopus 로고
    • Molecular basis for cell membrane electroporation
    • Weaver JC. Molecular basis for cell membrane electroporation. Ann NY Acad Sci 1994; 720: 141-152.
    • (1994) Ann NY Acad Sci , vol.720 , pp. 141-152
    • Weaver, J.C.1
  • 68
    • 0025996465 scopus 로고
    • Electrically induced DNA uptake by cells is a fast process involving DNA electrophoresis
    • Klenchin VA et al. Electrically induced DNA uptake by cells is a fast process involving DNA electrophoresis. Biophys J 1991; 60: 804-811.
    • (1991) Biophys J , vol.60 , pp. 804-811
    • Klenchin, V.A.1
  • 69
    • 0026685210 scopus 로고
    • Electroporation and electrophoretic DNA transfer into cells. The effect of DNA interaction with electropores
    • Sukharev SI et al. Electroporation and electrophoretic DNA transfer into cells. The effect of DNA interaction with electropores. Biophys J 1992; 63: 1320-1327.
    • (1992) Biophys J , vol.63 , pp. 1320-1327
    • Sukharev, S.I.1
  • 70
    • 0031910791 scopus 로고    scopus 로고
    • In vivo electrically mediated protein and gene transfer in murine melanoma
    • Rols MP et al. In vivo electrically mediated protein and gene transfer in murine melanoma. Nat Biotechnol 1998; 16: 168-171.
    • (1998) Nat Biotechnol , vol.16 , pp. 168-171
    • Rols, M.P.1
  • 71
    • 0020339802 scopus 로고
    • Gene transfer into mouse lyoma cells by electroporation in high electric fields
    • Neumann E, Schaefer-Ridder M, Wang Y, Hofschneider PH. Gene transfer into mouse lyoma cells by electroporation in high electric fields. EMBO J 1982; 1: 841-845.
    • (1982) EMBO J , vol.1 , pp. 841-845
    • Neumann, E.1    Schaefer-Ridder, M.2    Wang, Y.3    Hofschneider, P.H.4
  • 72
    • 0023895373 scopus 로고
    • Introduction of definite amounts of nonpermeant molecules into living cells after electropermeabilization: Direct access to the cytosol
    • Mir LM et al. Introduction of definite amounts of nonpermeant molecules into living cells after electropermeabilization: direct access to the cytosol. Exp Cell Res 1988; 175: 15-25.
    • (1988) Exp Cell Res , vol.175 , pp. 15-25
    • Mir, L.M.1
  • 73
    • 4243080427 scopus 로고    scopus 로고
    • Plasmid DNA electrotransfer for intracellular and secreted proteins expression: New methodological developments and applications
    • Bloquel C, Fabre E, Bureau MF, Scherman D. Plasmid DNA electrotransfer for intracellular and secreted proteins expression: new methodological developments and applications. J Gene Med 2004; 6 (Suppl 1): S11-S23.
    • (2004) J Gene Med , vol.6 , pp. S11-S23
    • Bloquel, C.1    Fabre, E.2    Bureau, M.F.3    Scherman, D.4
  • 74
    • 0025866525 scopus 로고
    • Gene transfer into human leukemia cell lines by electroporation: Experience with exponentially decaying and square wave pulse
    • Takahashi M et al. Gene transfer into human leukemia cell lines by electroporation: experience with exponentially decaying and square wave pulse. Leuk Res 1991; 15: 507-513.
    • (1991) Leuk Res , vol.15 , pp. 507-513
    • Takahashi, M.1
  • 75
    • 0026042713 scopus 로고
    • Optimization of transient transfection into human myeloid cell lines using a luciferase reporter gene
    • Pahl HL, Burn TC, Tenen DG. Optimization of transient transfection into human myeloid cell lines using a luciferase reporter gene. Exp Hematol 1991; 19: 1038-1041.
    • (1991) Exp Hematol , vol.19 , pp. 1038-1041
    • Pahl, H.L.1    Burn, T.C.2    Tenen, D.G.3
  • 76
    • 0022444510 scopus 로고
    • Stable expression of selectable genes introduced into human hematopoietic stem cells by electric field- mediated DNA transfer
    • Toneguzzo F, Keating A. Stable expression of selectable genes introduced into human hematopoietic stem cells by electric field- mediated DNA transfer. Proc Natl Acad Sci USA 1986; 83:3496-3499.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 3496-3499
    • Toneguzzo, F.1    Keating, A.2
  • 77
    • 0025033069 scopus 로고
    • Gene transfer by electroporation: A model for gene therapy
    • Keating A, Toneguzzo F. Gene transfer by electroporation: a model for gene therapy. Prog Clin Biol Res 1990; 333: 491-498.
    • (1990) Prog Clin Biol Res , vol.333 , pp. 491-498
    • Keating, A.1    Toneguzzo, F.2
  • 78
    • 0035084827 scopus 로고    scopus 로고
    • Efficient expression of foreign genes in human CD34+ hematopoietic precursor cells using electroporation
    • Wu MH et al. Efficient expression of foreign genes in human CD34+ hematopoietic precursor cells using electroporation. Gene Therapy 2001; 8: 384-390.
    • (2001) Gene Therapy , vol.8 , pp. 384-390
    • Wu, M.H.1
  • 79
    • 0035182857 scopus 로고    scopus 로고
    • High efficiency electroporation of human umbilical cord blood CD34+ hematopoietic precursor cells
    • Wu MH, Smith SL, Dolan ME. High efficiency electroporation of human umbilical cord blood CD34+ hematopoietic precursor cells. Stem Cells 2001; 19: 492-499.
    • (2001) Stem Cells , vol.19 , pp. 492-499
    • Wu, M.H.1    Smith, S.L.2    Dolan, M.E.3
  • 80
    • 0034948523 scopus 로고    scopus 로고
    • Optimization of culture conditions to enhance transfection of human CD34+ cells by electroporation
    • Wu MH et al. Optimization of culture conditions to enhance transfection of human CD34+ cells by electroporation. Bone Marrow Transplant 2001; 27: 1201-1209.
    • (2001) Bone Marrow Transplant , vol.27 , pp. 1201-1209
    • Wu, M.H.1
  • 81
    • 0032424854 scopus 로고    scopus 로고
    • Successful transfer of ADA gene in vitro into human peripheral blood CD34+ cells by transfecting EBV-based episomal vectors
    • Satoh E et al. Successful transfer of ADA gene in vitro into human peripheral blood CD34+ cells by transfecting EBV-based episomal vectors. FEBS Lett 1998; 441: 39-42.
    • (1998) FEBS Lett , vol.441 , pp. 39-42
    • Satoh, E.1
  • 82
    • 0042887572 scopus 로고    scopus 로고
    • Transient RNA interference in hematopoietic progenitors with functional consequences
    • Oliveira DM, Goodell MA. Transient RNA interference in hematopoietic progenitors with functional consequences. Genesis 2003; 36: 203-208.
    • (2003) Genesis , vol.36 , pp. 203-208
    • Oliveira, D.M.1    Goodell, M.A.2
  • 83
    • 0033839608 scopus 로고    scopus 로고
    • High-level transgene expression in primary human T lymphocytes and adult bone marrow CD34+ cells via electroporation-mediated gene deliver
    • Van Tendeloo VF et al. High-level transgene expression in primary human T lymphocytes and adult bone marrow CD34+ cells via electroporation-mediated gene delivery. Gene Therapy 2000; 7: 1431-1437.
    • (2000) Gene Therap , pp. 1431-2143
    • Van Tendelo, V.1
  • 84
    • 0037320203 scopus 로고    scopus 로고
    • Gene transfer in purified human hematopoietic peripheral-blood stem cells by means of electroporation without prestimulation
    • Weissinger F et al. Gene transfer in purified human hematopoietic peripheral-blood stem cells by means of electroporation without prestimulation. J Lab Clin Med 2003; 141: 138-149.
    • (2003) J Lab Clin Med , vol.141 , pp. 138-149
    • Weissinger, F.1
  • 85
    • 0025797053 scopus 로고
    • Efficient introduction of a gene into hematopoietic cells in S-phase by electroporation
    • Takahashi M et al. Efficient introduction of a gene into hematopoietic cells in S-phase by electroporation. Exp Hematol 1991; 19: 343-346.
    • (1991) Exp Hematol , vol.19 , pp. 343-346
    • Takahashi, M.1
  • 86
    • 0026670328 scopus 로고
    • Gene introduction into granulocyte-macrophage progenitor cells by electroporation: The relationship between introduction efficiency and the proportion of cells in S-phase
    • Takahashi M et al. Gene introduction into granulocyte-macrophage progenitor cells by electroporation: the relationship between introduction efficiency and the proportion of cells in S-phase. Leuk Res 1992; 16: 761-767.
    • (1992) Leuk Res , vol.16 , pp. 761-767
    • Takahashi, M.1
  • 87
    • 0024561548 scopus 로고
    • The effect of cell synchronization in the efficiency of stable gene transfer by electroporation
    • Yorifuji T, Tsuruta S, Mikawa H. The effect of cell synchronization in the efficiency of stable gene transfer by electroporation. FEBS Lett 1989; 245: 201-203.
    • (1989) FEBS Lett , vol.245 , pp. 201-203
    • Yorifuji, T.1    Tsuruta, S.2    Mikawa, H.3
  • 88
    • 84984775882 scopus 로고    scopus 로고
    • Gene transfer into human hematopoietic progenitor cells with an episomal vector carrying a SlMAR element
    • 11 August
    • Papapetrou EP et al. Gene transfer into human hematopoietic progenitor cells with an episomal vector carrying a SlMAR element. Gene Therapy advance online publication, 11 August 2005;.
    • (2005) Gene Therapy Advance Online Publication
    • Papapetrou, E.P.1
  • 89
    • 0035286642 scopus 로고    scopus 로고
    • High-efficiency electrotransfection of human primary hematopoietic stem cells
    • Li LH, McCarthy P, Hui SW. High-efficiency electrotransfection of human primary hematopoietic stem cells. FASEB J 2001; 15: 586-588.
    • (2001) FASEB J , vol.15 , pp. 586-588
    • Li, L.H.1    McCarthy, P.2    Hui, S.W.3
  • 90
    • 0032821009 scopus 로고    scopus 로고
    • Pathological consequences of unavoidable plasmid contamination with lipopolysaccharide
    • Gordillo GM. Pathological consequences of unavoidable plasmid contamination with lipopolysaccharide. Transplant Immunol 1999; 7: 83-94.
    • (1999) Transplant Immunol , vol.7 , pp. 83-94
    • Gordillo, G.M.1
  • 91
    • 0035412401 scopus 로고    scopus 로고
    • Highly efficient gene delivery by mRNA electroporation in human hematopoietic cells: Superiority to lipofection and passive pulsing of mRNA and to electroporation of plasmid cDNA for tumor antigen loading of dendritic cells
    • Van Tendeloo VF et al. Highly efficient gene delivery by mRNA electroporation in human hematopoietic cells: superiority to lipofection and passive pulsing of mRNA and to electroporation of plasmid cDNA for tumor antigen loading of dendritic cells. Blood 2001; 98: 49-56.
    • (2001) Blood , vol.98 , pp. 49-56
    • Van Tendeloo, V.F.1
  • 92
    • 0032791198 scopus 로고    scopus 로고
    • In vivo electroporation of skeletal muscle: Threshold, efficacy and relation to electric field distribution
    • Gehl J et al. In vivo electroporation of skeletal muscle: threshold, efficacy and relation to electric field distribution. Biochim Biophys Acta 1999; 1428: 233-240.
    • (1999) Biochim Biophys Acta , vol.1428 , pp. 233-240
    • Gehl, J.1
  • 93
    • 0017720373 scopus 로고    scopus 로고
    • Voltage-induced pore formation and hemolysis of human erythrocytes
    • Kinosita K, Tsong TY. Voltage-induced pore formation and hemolysis of human erythrocytes. Biochim Biophys Acta 1997; 471: 227-242.
    • (1997) Biochim Biophys Acta , vol.471 , pp. 227-242
    • Kinosita, K.1    Tsong, T.Y.2
  • 94
    • 0026596557 scopus 로고
    • Surfactant-induced sealing of electropermeabi- lized skeletal muscle membranes in vivo
    • Lee RC et al. Surfactant-induced sealing of electropermeabi- lized skeletal muscle membranes in vivo. Proc Natl Acad Sci USA 1992; 89: 4524-4528.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 4524-4528
    • Lee, R.C.1
  • 95
    • 0033573074 scopus 로고    scopus 로고
    • Apoptosis induced by DNA-uptake limits transfection efficiency
    • Li LH et al. Apoptosis induced by DNA-uptake limits transfection efficiency. Exp Cell Res 1999; 253: 541-550.
    • (1999) Exp Cell Res , vol.253 , pp. 541-550
    • Li, L.H.1
  • 96
    • 0032942188 scopus 로고    scopus 로고
    • Electric field pulses can induce apoptosis
    • Hofmann F et al. Electric field pulses can induce apoptosis. J Membr Biol 1999; 169: 103-109.
    • (1999) J Membr Biol , vol.169 , pp. 103-109
    • Hofmann, F.1
  • 97
    • 0031561735 scopus 로고    scopus 로고
    • Gene transfection of mouse primordial germ cells in vitro and analysis of their survival and growth control
    • Watanabe M et al. Gene transfection of mouse primordial germ cells in vitro and analysis of their survival and growth control. Exp Cell Res 1997; 230: 76-83.
    • (1997) Exp Cell Res , vol.230 , pp. 76-83
    • Watanabe, M.1
  • 98
    • 0033002204 scopus 로고    scopus 로고
    • Improving electrotransfection efficiency by post-pulse centrifugation
    • Li LH, Ross P, Hui SW. Improving electrotransfection efficiency by post-pulse centrifugation. Gene Therapy 1999; 6: 364-372.
    • (1999) Gene Therapy , vol.6 , pp. 364-372
    • Li, L.H.1    Ross, P.2    Hui, S.W.3
  • 99
    • 0017767161 scopus 로고    scopus 로고
    • Formation and resealing of pores of controlled sizes in human erythrocyte membranes
    • Kinosita K, Tsong TY. Formation and resealing of pores of controlled sizes in human erythrocyte membranes. Nature 1997; 268: 438-441.
    • (1997) Nature , vol.268 , pp. 438-441
    • Kinosita, K.1    Tsong, T.Y.2
  • 100
    • 0031779576 scopus 로고    scopus 로고
    • Enhancement of cytotoxicity by electropermeabilization: An improved method for screening drugs
    • Gehl J, Skovsgaard T, Mir LM. Enhancement of cytotoxicity by electropermeabilization: an improved method for screening drugs. Anticancer Drugs 1998; 9: 319-325.
    • (1998) Anticancer Drugs , vol.9 , pp. 319-325
    • Gehl, J.1    Skovsgaard, T.2    Mir, L.M.3
  • 101
    • 0033879422 scopus 로고    scopus 로고
    • Pulsed electric fields for selection of hematopoietic cells and depletion of tumor cell contaminants
    • Eppich HM et al. Pulsed electric fields for selection of hematopoietic cells and depletion of tumor cell contaminants. Nat Biotechnol 2000; 18: 882-887.
    • (2000) Nat Biotechnol , vol.18 , pp. 882-887
    • Eppich, H.M.1
  • 102
    • 0142183467 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor and interleukin-3 induce cell cycle progression through the synthesis of c-Myc protein by internal ribosome entry site-mediated translation via phosphatidylino- sitol 3-kinase pathway in human factor-dependent leukemic cells
    • Kobayashi N, Saeki K, Yuo A. Granulocyte-macrophage colony-stimulating factor and interleukin-3 induce cell cycle progression through the synthesis of c-Myc protein by internal ribosome entry site-mediated translation via phosphatidylino- sitol 3-kinase pathway in human factor-dependent leukemic cells. Blood 2003; 102: 3186-3195.
    • (2003) Blood , vol.102 , pp. 3186-3195
    • Kobayashi, N.1    Saeki, K.2    Yuo, A.3
  • 103
    • 2542475112 scopus 로고    scopus 로고
    • Caspase-3 has a nonapoptotic function in erythroid maturation
    • Carlile GW, Smith DH, Wiedmann M. Caspase-3 has a nonapoptotic function in erythroid maturation. Blood 2004; 103: 4310-4316.
    • (2004) Blood , vol.103 , pp. 4310-4316
    • Carlile, G.W.1    Smith, D.H.2    Wiedmann, M.3
  • 104
    • 2442679239 scopus 로고    scopus 로고
    • Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells
    • Podar K et al. Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells. J Biol Chem 2004; 279: 21658-21665.
    • (2004) J Biol Chem , vol.279 , pp. 21658-21665
    • Podar, K.1
  • 105
    • 0036107039 scopus 로고    scopus 로고
    • The effect of cell division on the cellular dynamics of microinjected DNA and dextran
    • Ludtke JJ, Sebestyen MG, Wolff JA. The effect of cell division on the cellular dynamics of microinjected DNA and dextran. Mol Ther 2002; 5: 579-588.
    • (2002) Mol Ther , vol.5 , pp. 579-588
    • Ludtke, J.J.1    Sebestyen, M.G.2    Wolff, J.A.3
  • 106
    • 0012143655 scopus 로고    scopus 로고
    • Transfection
    • Creighton TE, Wiley and Sons: New York
    • Baum C. Transfection. In: Creighton TE (ed). Encyclopedia of Molecular Biology. Wiley and Sons: New York, 1999, pp 2596-2600.
    • (1999) Encyclopedia of Molecular Biology , pp. 2596-2600
    • Baum, C.1
  • 107
    • 11144356610 scopus 로고    scopus 로고
    • Detection of integration of plasmid DNA into host genomic DNA following intramuscular injection and electroporation
    • Wang Z et al. Detection of integration of plasmid DNA into host genomic DNA following intramuscular injection and electroporation. Gene Therapy 2004; 11: 711-721.
    • (2004) Gene Therapy , vol.11 , pp. 711-721
    • Wang, Z.1
  • 108
    • 0028362004 scopus 로고
    • Association of a host DNA structure with retroviral integration sites in chromosomal DNA
    • Milot E, Belmaaza A, Rassart E, Chartrand P. Association of a host DNA structure with retroviral integration sites in chromosomal DNA. Virology 1994; 20: 408-412.
    • (1994) Virology , vol.20 , pp. 408-412
    • Milot, E.1    Belmaaza, A.2    Rassart, E.3    Chartrand, P.4
  • 109
    • 0021281130 scopus 로고
    • Expression of genes introduced into cells by retroviral infection is more efficient than that of genes introduced into cells by DNA transfection
    • Hwang LH, Gilboa E. Expression of genes introduced into cells by retroviral infection is more efficient than that of genes introduced into cells by DNA transfection. J Virol 1984; 50: 417-424.
    • (1984) J Virol , vol.50 , pp. 417-424
    • Hwang, L.H.1    Gilboa, E.2
  • 110
    • 0030025649 scopus 로고    scopus 로고
    • Anatomy of highly expressing chromosomal sites targeted by retroviral vectors
    • Mielke C, Maass K, Tummler M, Bode J. Anatomy of highly expressing chromosomal sites targeted by retroviral vectors. Biochemistry 1996; 35: 2239-2252.
    • (1996) Biochemistry , vol.35 , pp. 2239-2252
    • Mielke, C.1    Maass, K.2    Tummler, M.3    Bode, J.4
  • 111
    • 0040186086 scopus 로고    scopus 로고
    • Transcriptional properties of genomic transgene integration sites marked by electroporation or retroviral infection
    • Baer A, Schubeler D, Bode J. Transcriptional properties of genomic transgene integration sites marked by electroporation or retroviral infection. Biochemistry 2000; 39: 7041-7049.
    • (2000) Biochemistry , vol.39 , pp. 7041-7049
    • Baer, A.1    Schubeler, D.2    Bode, J.3
  • 112
    • 0029984012 scopus 로고    scopus 로고
    • In vitro and in vivo liposome-mediated gene transfer leads to human MDR1 expression in mouse bone marrow progenitor cells
    • Aksentijevich I et al. In vitro and in vivo liposome-mediated gene transfer leads to human MDR1 expression in mouse bone marrow progenitor cells. Hum Gene Ther 1996; 7: 1111-1122.
    • (1996) Hum Gene Ther , vol.7 , pp. 1111-1122
    • Aksentijevich, I.1
  • 113
    • 0033009004 scopus 로고    scopus 로고
    • Therapeutic mammalian artificial chromosomes
    • Vos J-M. Therapeutic mammalian artificial chromosomes. Curr Opin Mol Ther 1999; 1: 204-205.
    • (1999) Curr Opin Mol Ther , vol.1 , pp. 204-205
    • Vos, J.-M.1
  • 114
    • 0035027612 scopus 로고    scopus 로고
    • Exploiting chromosomal and viral strategies: The design of safe and efficient non-viral gene transfer systems
    • Lipps HJ, Bode J. Exploiting chromosomal and viral strategies: the design of safe and efficient non-viral gene transfer systems. Curr Opin Mol Ther 2001; 3: 133-141.
    • (2001) Curr Opin Mol Ther , vol.3 , pp. 133-141
    • Lipps, H.J.1    Bode, J.2
  • 115
    • 0037472695 scopus 로고    scopus 로고
    • Chromosome-based vectors for gene therapy
    • Lipps HJ et al. Chromosome-based vectors for gene therapy. Gene 2003; 304: 23-33.
    • (2003) Gene , vol.304 , pp. 23-33
    • Lipps, H.J.1
  • 117
    • 0024564516 scopus 로고
    • Isolation of human sequences that replicate autonomously in human cells
    • Krysan PJ, Haase SB, Calos MP. Isolation of human sequences that replicate autonomously in human cells. Mol Cell Biol 1989; 9: 1026-1033.
    • (1989) Mol Cell Biol , vol.9 , pp. 1026-1033
    • Krysan, P.J.1    Haase, S.B.2    Calos, M.P.3
  • 118
    • 0031879482 scopus 로고    scopus 로고
    • Epstein-Barr-based episomal chromosomes shuttle 100 kb of self-replicating circular human DNA in mouse cells
    • Kelleher ZT et al. Epstein-Barr-based episomal chromosomes shuttle 100 kb of self-replicating circular human DNA in mouse cells. Nat Biotechnol 1998; 16: 762-768.
    • (1998) Nat Biotechnol , vol.16 , pp. 762-768
    • Kelleher, Z.T.1
  • 119
    • 0023084783 scopus 로고
    • Analysis of mutation in human cells by using an Epstein-Barr virus shuttle vector
    • DuBridge RB et al. Analysis of mutation in human cells by using an Epstein-Barr virus shuttle vector. Mol Cell Biol 1987; 7: 379-387.
    • (1987) Mol Cell Biol , vol.7 , pp. 379-387
    • Dubridge, R.B.1
  • 120
    • 0027117402 scopus 로고
    • Expression cloning of a human DNA repair gene involved in xeroderma pigmentosum group C
    • Legerski R, Peterson C. Expression cloning of a human DNA repair gene involved in xeroderma pigmentosum group C. Nature 1992; 360: 610.
    • (1992) Nature , vol.360 , pp. 610
    • Legerski, R.1    Peterson, C.2
  • 121
    • 0030280036 scopus 로고    scopus 로고
    • The potential of extrachromosomal replicating vectors for gene therapy
    • Calos MP. The potential of extrachromosomal replicating vectors for gene therapy. Trends Genet 1996; 12: 463-466.
    • (1996) Trends Genet , vol.12 , pp. 463-466
    • Calos, M.P.1
  • 122
    • 12644295026 scopus 로고    scopus 로고
    • Safety-modified episomal vectors for human gene therapy
    • Cooper MJ et al. Safety-modified episomal vectors for human gene therapy. Proc Natl Acad Sci USA 1997; 94: 6450-6455.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 6450-6455
    • Cooper, M.J.1
  • 123
    • 0032190685 scopus 로고    scopus 로고
    • Epstein-Barr virus vectors for gene expression and transfer
    • Sclimenti CR, Calos MP. Epstein-Barr virus vectors for gene expression and transfer. Curr Opin Biotechnol 1998; 9: 476-479.
    • (1998) Curr Opin Biotechnol , vol.9 , pp. 476-479
    • Sclimenti, C.R.1    Calos, M.P.2
  • 124
    • 0033669478 scopus 로고    scopus 로고
    • Stable correction of a genetic deficiency in human cells by an episome carrying a 115 kb genomic transgene
    • WadeMartins R et al. Stable correction of a genetic deficiency in human cells by an episome carrying a 115 kb genomic transgene. Nat Biotechnol 2000; 18: 1311-1314.
    • (2000) Nat Biotechnol , vol.18 , pp. 1311-1314
    • Wademartins, R.1
  • 125
    • 0036845672 scopus 로고    scopus 로고
    • Establishment of an oriPlEBNA1- based episomal vector transcribing human genomic ß-globin in cultured murine fibroblasts
    • Black J, Vos J-M. Establishment of an oriPlEBNA1- based episomal vector transcribing human genomic ß-globin in cultured murine fibroblasts. Gene Therapy 2002; 9: 1447-1454.
    • (2002) Gene Therapy , vol.9 , pp. 1447-1454
    • Black, J.1    Vos, J.-M.2
  • 126
    • 85047697219 scopus 로고    scopus 로고
    • LCR-mediated, long-term tissue-specific gene expression within replicating episomal plasmid and cosmid vectors
    • Chow C-M et al. LCR-mediated, long-term tissue-specific gene expression within replicating episomal plasmid and cosmid vectors. Gene Therapy 2002; 9: 327-336.
    • (2002) Gene Therapy , vol.9 , pp. 327-336
    • Chow, C.-M.1
  • 127
    • 0031587032 scopus 로고    scopus 로고
    • Extremely efficient gene transfection into lympho-hematopoietic cell lines by Epstein-Barr virus-based vectors
    • Mazda O, Satoh E, Yasutomi K, Imanishi J. Extremely efficient gene transfection into lympho-hematopoietic cell lines by Epstein-Barr virus-based vectors. J Immunol Methods 1997; 204: 143-151.
    • (1997) J Immunol Methods , vol.204 , pp. 143-151
    • Mazda, O.1    Satoh, E.2    Yasutomi, K.3    Imanishi, J.4
  • 128
    • 0028218843 scopus 로고
    • A reporter system using a flow cytometer to detect promoterlenhancer activity in lymphoid cell lines
    • Mazda O et al. A reporter system using a flow cytometer to detect promoterlenhancer activity in lymphoid cell lines. J Immunol Methods 1994; 169: 53-61.
    • (1994) J Immunol Methods , vol.169 , pp. 53-61
    • Mazda, O.1
  • 129
    • 8044248412 scopus 로고    scopus 로고
    • Suitability of Epstein-Barr virus-based episomal vectors for expression of cytokine genes in human lymphoma cells
    • Mucke S et al. Suitability of Epstein-Barr virus-based episomal vectors for expression of cytokine genes in human lymphoma cells. Gene Therapy 1997; 4: 82-92.
    • (1997) Gene Therapy , vol.4 , pp. 82-92
    • Mucke, S.1
  • 130
    • 0036705432 scopus 로고    scopus 로고
    • Extrachromosomal plasmid vectors for gene therapy
    • Stoll SM, Calos MP. Extrachromosomal plasmid vectors for gene therapy. Curr Opin Mol Ther 2002; 4: 299-305.
    • (2002) Curr Opin Mol Ther , vol.4 , pp. 299-305
    • Stoll, S.M.1    Calos, M.P.2
  • 131
    • 0025236738 scopus 로고
    • Amplified expression of tumor necrosis factor receptor in cells transfected with Epstein-Barr virus shuttle vector cDNA libraries
    • Heller RA et al. Amplified expression of tumor necrosis factor receptor in cells transfected with Epstein-Barr virus shuttle vector cDNA libraries. J Biol Chem 1990; 265: 5708-5717.
    • (1990) J Biol Chem , vol.265 , pp. 5708-5717
    • Heller, R.A.1
  • 132
    • 0028064993 scopus 로고
    • Human artificial episomal chromosomes for cloning large DNA fragments in human cells
    • Sun TQ, Fernstermacher DA, Vos JM. Human artificial episomal chromosomes for cloning large DNA fragments in human cells. Nat Genet 1994; 8: 33-41.
    • (1994) Nat Genet , vol.8 , pp. 33-41
    • Sun, T.Q.1    Fernstermacher, D.A.2    Vos, J.M.3
  • 133
    • 0029772322 scopus 로고    scopus 로고
    • Stable episomal maintenance of yeast artificial chromosomes in human cells
    • Simpson K, McGuigan A, Huxley C. Stable episomal maintenance of yeast artificial chromosomes in human cells. Mol Cell Biol 1996; 16: 5117-5126.
    • (1996) Mol Cell Biol , vol.16 , pp. 5117-5126
    • Simpson, K.1    McGuigan, A.2    Huxley, C.3
  • 134
    • 0025770628 scopus 로고
    • Efficient cDNA cloning by direct phenotypic correction of a mutant human cell line (HPRT—) using an Epstein-Barr virus-derived cDNA expression vector
    • Belt PB et al. Efficient cDNA cloning by direct phenotypic correction of a mutant human cell line (HPRT—) using an Epstein-Barr virus-derived cDNA expression vector. Nucleic Acids Res 1991; 19: 4861-4866.
    • (1991) Nucleic Acids Res , vol.19 , pp. 4861-4866
    • Belt, P.B.1
  • 135
    • 0036728587 scopus 로고    scopus 로고
    • Improvement of nonviral gene therapy by Epstein- Barr virus (EBV)-based plasmid vectors
    • Mazda O. Improvement of nonviral gene therapy by Epstein- Barr virus (EBV)-based plasmid vectors. Curr Gene Ther 2002; 2: 1-14.
    • (2002) Curr Gene Ther , vol.2 , pp. 1-14
    • Mazda, O.1
  • 136
    • 0026004036 scopus 로고
    • Epstein-Barr virus-derived plasmids replicate only once per cell cycle and are not amplified after entry into cells
    • Yates JL, Guan N. Epstein-Barr virus-derived plasmids replicate only once per cell cycle and are not amplified after entry into cells. J Virol 1991; 65: 483-488.
    • (1991) J Virol , vol.65 , pp. 483-488
    • Yates, J.L.1    Guan, N.2
  • 137
    • 0023183647 scopus 로고
    • Replication of latent Epstein-Barr virus genomes in Raji cells
    • Adams A. Replication of latent Epstein-Barr virus genomes in Raji cells. J Virol 1987; 61: 1590-1594.
    • (1987) J Virol , vol.61 , pp. 1590-1594
    • Adams, A.1
  • 138
    • 0022448397 scopus 로고
    • Chemically induced mutagenesis in a shuttle vector with a low-background mutant frequency
    • Drinkwater NR, Klinedinst DK. Chemically induced mutagenesis in a shuttle vector with a low-background mutant frequency. Proc Natl Acad Sci USA 1986; 83: 3402-3406.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 3402-3406
    • Drinkwater, N.R.1    Klinedinst, D.K.2
  • 139
    • 0025361222 scopus 로고
    • Differences in human cell lines to support stable replication of Epstein-Barr virus-based vectors
    • Vidal M et al. Differences in human cell lines to support stable replication of Epstein-Barr virus-based vectors. Biochim Biophys Acta 1990; 1048: 171-177.
    • (1990) Biochim Biophys Acta , vol.1048 , pp. 171-177
    • Vidal, M.1
  • 140
    • 0027755364 scopus 로고
    • Epstein-Barr virus-based vectors that replicate in rodent cells
    • Krysan PJ, Calos MP. Epstein-Barr virus-based vectors that replicate in rodent cells. Gene 1993; 136: 137-143.
    • (1993) Gene , vol.136 , pp. 137-143
    • Krysan, P.J.1    Calos, M.P.2
  • 141
    • 0031681367 scopus 로고    scopus 로고
    • Sustained transgene expression in vitro and in vivo using an Epstein-Barr virus replicon vector system combined with HVJ liposomes
    • Saeki Y, Wataya-Kaneda M, Tanaka K, Kaneda Y. Sustained transgene expression in vitro and in vivo using an Epstein-Barr virus replicon vector system combined with HVJ liposomes. Gene Therapy 1998; 5: 1031-1037.
    • (1998) Gene Therapy , vol.5 , pp. 1031-1037
    • Saeki, Y.1    Wataya-Kaneda, M.2    Tanaka, K.3    Kaneda, Y.4
  • 142
    • 0028978017 scopus 로고
    • Plasmid maintenance of derivatives of oriP of Epstein-Barr virus
    • Kirchmaier AL, Sugden B. Plasmid maintenance of derivatives of oriP of Epstein-Barr virus. J Virol 1995; 69: 1280-1283.
    • (1995) J Virol , vol.69 , pp. 1280-1283
    • Kirchmaier, A.L.1    Sugden, B.2
  • 143
    • 0028340110 scopus 로고
    • Retention of plasmid DNA in mammalian cells is enhanced by binding of the Epstein-Barr virus replication protein EBNA1
    • Middleton T, Sugden B. Retention of plasmid DNA in mammalian cells is enhanced by binding of the Epstein-Barr virus replication protein EBNA1. J Virol 1994; 68: 4067-4071.
    • (1994) J Virol , vol.68 , pp. 4067-4071
    • Middleton, T.1    Sugden, B.2
  • 144
    • 0027374736 scopus 로고
    • Efficient transcriptional activation of many simple modular promoters by simian virus 40 large T-antigen
    • Rice PW, Cole CN. Efficient transcriptional activation of many simple modular promoters by simian virus 40 large T-antigen. J Virol 1993; 67: 6689-6697.
    • (1993) J Virol , vol.67 , pp. 6689-6697
    • Rice, P.W.1    Cole, C.N.2
  • 146
    • 0032472871 scopus 로고    scopus 로고
    • Murine cytotoxic T lymphocytes recognize an epitope in an EBNA-1 fragment, but fail to lyse EBNA-1- expressing mouse cells
    • Mukherjee S et al. Murine cytotoxic T lymphocytes recognize an epitope in an EBNA-1 fragment, but fail to lyse EBNA-1- expressing mouse cells. J Exp Med 1998; 187: 445-450.
    • (1998) J Exp Med , vol.187 , pp. 445-450
    • Mukherjee, S.1
  • 147
    • 0030014205 scopus 로고    scopus 로고
    • Expression of Epstein-Barr virus nuclear antigen-1 induces B cell neoplasia in transgenic mice
    • Wilson JB, Bell JL, Levine AJ. Expression of Epstein-Barr virus nuclear antigen-1 induces B cell neoplasia in transgenic mice. EMBO J 1996; 15: 3117-3126.
    • (1996) EMBO J , vol.15 , pp. 3117-3126
    • Wilson, J.B.1    Bell, J.L.2    Levine, A.J.3
  • 148
    • 0027970971 scopus 로고
    • EBNA-1, the major nuclear antigen of Epstein-Barr virus, resembles 'RGG' RNA binding proteins
    • Snudden DK et al. EBNA-1, the major nuclear antigen of Epstein-Barr virus, resembles 'RGG' RNA binding proteins. EMBO J 1994; 13: 4840-4847.
    • (1994) EMBO J , vol.13 , pp. 4840-4847
    • Snudden, D.K.1
  • 149
    • 9344221644 scopus 로고    scopus 로고
    • Episomal expression of wild-type CFTR corrects cAMP-dependent chloride transport in respiratory epithelial cells
    • Lei DC et al. Episomal expression of wild-type CFTR corrects cAMP-dependent chloride transport in respiratory epithelial cells. Gene Therapy 1996; 3: 427-436.
    • (1996) Gene Therapy , vol.3 , pp. 427-436
    • Lei, D.C.1
  • 150
    • 0028792185 scopus 로고
    • Therapeutic gene delivery in human B-lymphoblastoid cells by engineered non-transforming infectious Epstein-Barr virus
    • Banerjee S, Livanos E, Vos J-M. Therapeutic gene delivery in human B-lymphoblastoid cells by engineered non-transforming infectious Epstein-Barr virus. Nat Med 1995; 1: 1303-1308.
    • (1995) Nat Med , vol.1 , pp. 1303-1308
    • Banerjee, S.1    Livanos, E.2    Vos, J.-M.3
  • 151
    • 0021988550 scopus 로고
    • Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cells
    • Yates JL, Warren N, Sugden B. Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cells. Nature 1985; 313: 812-815.
    • (1985) Nature , vol.313 , pp. 812-815
    • Yates, J.L.1    Warren, N.2    Sugden, B.3
  • 152
    • 0036276531 scopus 로고    scopus 로고
    • Chromosome engineering: Prospects for gene therapy
    • Grimes BR, Warburton PE, Farr CJ. Chromosome engineering: prospects for gene therapy. Gene Therapy 2002; 9: 713-718.
    • (2002) Gene Therapy , vol.9 , pp. 713-718
    • Grimes, B.R.1    Warburton, P.E.2    Farr, C.J.3
  • 153
    • 0036369660 scopus 로고    scopus 로고
    • Strategies for engineering human chromosomes with therapeutic potential
    • Saffery R, Choo KH. Strategies for engineering human chromosomes with therapeutic potential. J Gene Med 2002; 4: 5-13.
    • (2002) J Gene Med , vol.4 , pp. 5-13
    • Saffery, R.1    Choo, K.H.2
  • 154
    • 0030910465 scopus 로고    scopus 로고
    • Formation of de novo centromeres and construction of first generation human artificial microchromosomes
    • Harrington JJ et al. Formation of de novo centromeres and construction of first generation human artificial microchromosomes. Nat Genet 1997; 15: 345-355.
    • (1997) Nat Genet , vol.15 , pp. 345-355
    • Harrington, J.J.1
  • 155
    • 0034755391 scopus 로고    scopus 로고
    • Stable expression from a mammalian artificial chromosome
    • Grimes BR et al. Stable expression from a mammalian artificial chromosome. EMBO Rep 2001; 2: 910-914.
    • (2001) EMBO Rep , vol.2 , pp. 910-914
    • Grimes, B.R.1
  • 156
    • 0034925026 scopus 로고    scopus 로고
    • Functional complementation of genetic deficiency with human artificial chromosomes
    • Meija JE et al. Functional complementation of genetic deficiency with human artificial chromosomes. Am J Hum Genet 2001; 69: 315-326.
    • (2001) Am J Hum Genet , vol.69 , pp. 315-326
    • Meija, J.E.1
  • 157
    • 0036748288 scopus 로고    scopus 로고
    • Functional human CFTR produced by a stable minichromosome
    • Auriche C et al. Functional human CFTR produced by a stable minichromosome. EMBO Rep 2002; 3: 826-828.
    • (2002) EMBO Rep , vol.3 , pp. 826-828
    • Auriche, C.1
  • 158
    • 27544483970 scopus 로고    scopus 로고
    • Transgene expression after stable transfer of a mammalian artificial chromosome into human hematopoietic cells
    • (abstract 498)
    • Vanderbyl S et al. Transgene expression after stable transfer of a mammalian artificial chromosome into human hematopoietic cells. Blood 2004; 104:(abstract 498).
    • (2004) Blood , vol.104
    • Vanderbyl, S.1
  • 159
    • 0033555686 scopus 로고    scopus 로고
    • A vector based on the SV40 origin of replication and chromosomal SlMARs replicates episomally in CHO cells
    • Piechaczek C et al. A vector based on the SV40 origin of replication and chromosomal SlMARs replicates episomally in CHO cells. Nucleic Acids Res 1999; 27: 426-428.
    • (1999) Nucleic Acids Res , vol.27 , pp. 426-428
    • Piechaczek, C.1
  • 160
    • 0026597313 scopus 로고
    • Biological significance of unwinding capability of nuclear matrix-associating DNAs
    • Bode J et al. Biological significance of unwinding capability of nuclear matrix-associating DNAs. Science 1992; 255: 195-197.
    • (1992) Science , vol.255 , pp. 195-197
    • Bode, J.1
  • 161
    • 0842307053 scopus 로고    scopus 로고
    • An episomal mammalian replicon: Sequence-independent binding of the origin recognition complex
    • Schaarschmidt D et al. An episomal mammalian replicon: sequence-independent binding of the origin recognition complex. EMBO J 2004; 23: 191-201.
    • (2004) EMBO J , vol.23 , pp. 191-201
    • Schaarschmidt, D.1
  • 162
    • 3042730820 scopus 로고    scopus 로고
    • Expression of a transgene encoded on a non-viral episomal vector is not subject S129 to epigenetic silencing by cytokine methylation
    • Jenke AC, Scinteie MF, Stehle IM, Lipps HJ. Expression of a transgene encoded on a non-viral episomal vector is not subject S129 to epigenetic silencing by cytokine methylation. Mol Biol Rep 2004; 31: 85-90.
    • (2004) Mol Biol Rep , vol.31 , pp. 85-90
    • Jenke, A.C.1    Scinteie, M.F.2    Stehle, I.M.3    Lipps, H.J.4
  • 163
    • 0033780721 scopus 로고    scopus 로고
    • Mitotic stability of an episomal vector containing a human scaffoldlmatrix-attached region is provided by association with nuclear matrix
    • Baiker A et al. Mitotic stability of an episomal vector containing a human scaffoldlmatrix-attached region is provided by association with nuclear matrix. Nat Cell Biol 2000; 2: 182-184.
    • (2000) Nat Cell Biol , vol.2 , pp. 182-184
    • Baiker, A.1
  • 164
    • 0036246051 scopus 로고    scopus 로고
    • An episomally replicating vector binds to the nuclear matrix protein SAF-A in vivo
    • Jenke BH et al. An episomally replicating vector binds to the nuclear matrix protein SAF-A in vivo. EMBO Rep 2002; 3: 349-354.
    • (2002) EMBO Rep , vol.3 , pp. 349-354
    • Jenke, B.H.1
  • 165
    • 0031880828 scopus 로고    scopus 로고
    • Growth factors increase retroviral transduction but decrease clonogenic potential of umbilical cord blood CD34+ cells
    • Corrias MV et al. Growth factors increase retroviral transduction but decrease clonogenic potential of umbilical cord blood CD34+ cells. Haematologica 1998; 83: 580-586.
    • (1998) Haematologica , vol.83 , pp. 580-586
    • Corrias, M.V.1
  • 166
    • 0032962975 scopus 로고    scopus 로고
    • Metabolic instability of plasmid DNA in the cytosol: A potential barrier to gene transfer
    • Lechardeur D et al. Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer. Gene Therapy 1999; 6: 482-497.
    • (1999) Gene Therapy , vol.6 , pp. 482-497
    • Lechardeur, D.1
  • 167
    • 0030875903 scopus 로고    scopus 로고
    • The role of the nuclear pore complex in adenovirus DNA entry
    • Greber UF et al. The role of the nuclear pore complex in adenovirus DNA entry. EMBO J 1997; 16: 5998-6007.
    • (1997) EMBO J , vol.16 , pp. 5998-6007
    • Greber, U.F.1
  • 168
    • 0024597585 scopus 로고
    • Increased expression of DNA cointroduced with nuclear protein in adult rat liver
    • Kaneda Y, Iwai K, Uchida T. Increased expression of DNA cointroduced with nuclear protein in adult rat liver. Science 1989; 243: 375-378.
    • (1989) Science , vol.243 , pp. 375-378
    • Kaneda, Y.1    Iwai, K.2    Uchida, T.3
  • 169
    • 0033524453 scopus 로고    scopus 로고
    • Gene delivery: A single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus
    • Zanta M-A, Belguise-Valladier P, Behr J-P. Gene delivery: a single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus. Proc Natl Acad Sci USA 1999; 96: 91-96.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 91-96
    • Zanta, M.-A.1    Belguise-Valladier, P.2    Behr, J.-P.3
  • 170
    • 0028939896 scopus 로고
    • Targeted gene transfer into hepatoma cells with lipopolyamine-condensed DNA particles presenting galactose ligands: A stage toward artificial viruses
    • Remy JS et al. Targeted gene transfer into hepatoma cells with lipopolyamine-condensed DNA particles presenting galactose ligands: a stage toward artificial viruses. Proc Natl Acad Sci USA 1995; 92: 1744-1748.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 1744-1748
    • Remy, J.S.1
  • 171
    • 15844404886 scopus 로고    scopus 로고
    • Target cell-specific DNA transfer mediated by a chimeric multidomain protein. Novel non-viral gene delivery system
    • Fominaya J, Wels W. Target cell-specific DNA transfer mediated by a chimeric multidomain protein. Novel non-viral gene delivery system. J Biol Chem 1996; 271: 10560-10568.
    • (1996) J Biol Chem , vol.271 , pp. 10560-10568
    • Fominaya, J.1    Wels, W.2
  • 172
    • 0029976870 scopus 로고    scopus 로고
    • Genetically engineered poxviruses for recombinant gene expression, vaccination, and safety
    • Moss B. Genetically engineered poxviruses for recombinant gene expression, vaccination, and safety. Proc Natl Acad Sci USA 1996; 93: 11341-11348.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 11341-11348
    • Moss, B.1
  • 173
    • 0037320759 scopus 로고    scopus 로고
    • Recombinant Sendai virus provides a highly efficient gene transfer into human cord blood-derived hematopoietic stem cells
    • Jin CH et al. Recombinant Sendai virus provides a highly efficient gene transfer into human cord blood-derived hematopoietic stem cells. Gene Therapy 2003; 10: 272-277.
    • (2003) Gene Therapy , vol.10 , pp. 272-277
    • Jin, C.H.1
  • 174
    • 0036932834 scopus 로고    scopus 로고
    • In vivo correction of murine tyrosinemia type I by DNA-mediated transposition
    • Montini E et al. In vivo correction of murine tyrosinemia type I by DNA-mediated transposition. Mol Ther 2002; 6: 759-769.
    • (2002) Mol Ther , vol.6 , pp. 759-769
    • Montini, E.1
  • 175
    • 0036842502 scopus 로고    scopus 로고
    • Site-specific genomic integration produces therapeutic Factor IX levels in mice
    • Olivares EC et al. Site-specific genomic integration produces therapeutic Factor IX levels in mice. Nat Biotechnol 2002; 20: 1124-1128.
    • (2002) Nat Biotechnol , vol.20 , pp. 1124-1128
    • Olivares, E.C.1
  • 176
    • 0036797451 scopus 로고    scopus 로고
    • Stable nonviral genetic correction of inherited human skin disease
    • Ortiz-Urda S et al. Stable nonviral genetic correction of inherited human skin disease. Nat Med 2002; 8: 1166-1170.
    • (2002) Nat Med , vol.8 , pp. 1166-1170
    • Ortiz-Urda, S.1
  • 177
    • 0035351210 scopus 로고    scopus 로고
    • Time course of gene expression after plasmid DNA gene transfer to the liver
    • Herweijer H et al. Time course of gene expression after plasmid DNA gene transfer to the liver. J Gene Med 2001; 3: 280-291.
    • (2001) J Gene Med , vol.3 , pp. 280-291
    • Herweijer, H.1
  • 178
    • 0029834562 scopus 로고    scopus 로고
    • Evaluation of promoter strength for hepatic gene expression in vivo following adenovirus-mediated gene transfer
    • Guo ZS, Wang LH, Eisensmith RC, Woo SL. Evaluation of promoter strength for hepatic gene expression in vivo following adenovirus-mediated gene transfer. Gene Therapy 1996; 3: 802-810.
    • (1996) Gene Therapy , vol.3 , pp. 802-810
    • Guo, Z.S.1    Wang, L.H.2    Eisensmith, R.C.3    Woo, S.L.4
  • 179
    • 0030996180 scopus 로고    scopus 로고
    • Optimization of plasmid vectors for high-level expression in lung epithelial cells
    • Yew NS et al. Optimization of plasmid vectors for high-level expression in lung epithelial cells. Hum Gene Ther 1997; 8: 575-584.
    • (1997) Hum Gene Ther , vol.8 , pp. 575-584
    • Yew, N.S.1
  • 180
    • 2642673611 scopus 로고    scopus 로고
    • Reactivation of the previously silenced cytomegalovirus major immediate-early promoter in the mouse liver: Involvement of NFkappaB
    • Loser P, Jennings GS, Strauss M, Sandig V. Reactivation of the previously silenced cytomegalovirus major immediate-early promoter in the mouse liver: involvement of NFkappaB. J Virol 1998; 72: 180-190.
    • (1998) J Virol , vol.72 , pp. 180-190
    • Loser, P.1    Jennings, G.S.2    Strauss, M.3    Sandig, V.4
  • 181
    • 0031581174 scopus 로고    scopus 로고
    • Promoter attenuation in gene therapy: Interferongamma and tumor necrosis factor-alpha inhibit transgene expression
    • Qin L et al. Promoter attenuation in gene therapy: interferongamma and tumor necrosis factor-alpha inhibit transgene expression. Hum Gene Ther 1997; 8: 2019-2029.
    • (1997) Hum Gene Ther , vol.8 , pp. 2019-2029
    • Qin, L.1
  • 182
    • 0033200187 scopus 로고    scopus 로고
    • CpG: The double-edged sword
    • Paillard F. CpG: the double-edged sword. Hum Gene Ther 1999; 10: 2089-2090.
    • (1999) Hum Gene Ther , vol.10 , pp. 2089-2090
    • Paillard, F.1
  • 183
    • 2642519089 scopus 로고    scopus 로고
    • Silencing of episomal transgene expression by plasmid bacterial DNA elements in vivo
    • Chen ZY, He CY, Meuse L, Kay MA. Silencing of episomal transgene expression by plasmid bacterial DNA elements in vivo. Gene Therapy 2004; 11: 856-864.
    • (2004) Gene Therapy , vol.11 , pp. 856-864
    • Chen, Z.Y.1    He, C.Y.2    Meuse, L.3    Kay, M.A.4
  • 184
    • 0033199598 scopus 로고    scopus 로고
    • The inhibitory role of CpG immunostimulatory motifs in cationic lipid vector-mediated transgene expression in vivo
    • Tan Y, Li S, Pitt BR, Huang L. The inhibitory role of CpG immunostimulatory motifs in cationic lipid vector-mediated transgene expression in vivo. Hum Gene Ther 1999; 10: 2153-2161.
    • (1999) Hum Gene Ther , vol.10 , pp. 2153-2161
    • Tan, Y.1    Li, S.2    Pitt, B.R.3    Huang, L.4
  • 185
    • 0028931102 scopus 로고
    • CpG motifs in bacterial DNA trigger direct B-cell activation
    • Krieg AM et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 1995; 374: 546-549.
    • (1995) Nature , vol.374 , pp. 546-549
    • Krieg, A.M.1
  • 186
    • 0032514616 scopus 로고    scopus 로고
    • Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs
    • Krieg AM et al. Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs. Proc Natl Acad Sci USA 1998; 95: 12631-12636.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 12631-12636
    • Krieg, A.M.1
  • 187
    • 0035166381 scopus 로고    scopus 로고
    • Increased persistence of lung gene expression using plasmids containing the ubiquitin C or elongation factor 1alpha promoter
    • Gill DR et al. Increased persistence of lung gene expression using plasmids containing the ubiquitin C or elongation factor 1alpha promoter. Gene Therapy 2001; 8: 1539-1546.
    • (2001) Gene Therapy , vol.8 , pp. 1539-1546
    • Gill, D.R.1
  • 188
    • 0041911490 scopus 로고    scopus 로고
    • Long-term therapeutic levels of human alpha-1 antitrypsin in plasma after hydrodynamic injection of nonviral DNA
    • Alino SF, Crespo A, Dasi F. Long-term therapeutic levels of human alpha-1 antitrypsin in plasma after hydrodynamic injection of nonviral DNA. Gene Therapy 2003; 10: 1672-1679.
    • (2003) Gene Therapy , vol.10 , pp. 1672-1679
    • Alino, S.F.1    Crespo, A.2    Dasi, F.3
  • 189
    • 0035132414 scopus 로고    scopus 로고
    • Efficient in vivo gene transfer by PCR amplified fragment with reduced inflammatory activity
    • Hofman CR et al. Efficient in vivo gene transfer by PCR amplified fragment with reduced inflammatory activity. Gene Therapy 2001; 8: 71-74.
    • (2001) Gene Therapy , vol.8 , pp. 71-74
    • Hofman, C.R.1
  • 190
    • 0031436820 scopus 로고    scopus 로고
    • A new DNA vehicle for nonviral gene delivery: Supercoiled minicircle
    • Darquet AM et al. A new DNA vehicle for nonviral gene delivery: supercoiled minicircle. Gene Therapy 1997; 4:1341-1349.
    • (1997) Gene Therapy , vol.4 , pp. 1341-1349
    • Darquet, A.M.1
  • 191
    • 8244259179 scopus 로고    scopus 로고
    • Lymphocyte apoptosis induction by gene transfer techniques
    • Ebert O et al. Lymphocyte apoptosis induction by gene transfer techniques. Gene Therapy 1997; 4: 296-302.
    • (1997) Gene Therapy , vol.4 , pp. 296-302
    • Ebert, O.1
  • 192
    • 0033585425 scopus 로고    scopus 로고
    • Contribution of plasmid DNA to inflammation in the lung after administration of cationic lipid:PDNA complexes
    • Yew NS et al. Contribution of plasmid DNA to inflammation in the lung after administration of cationic lipid:pDNA complexes. Hum Gene Ther 1999; 10: 223-234.
    • (1999) Hum Gene Ther , vol.10 , pp. 223-234
    • Yew, N.S.1
  • 193
    • 3042667834 scopus 로고    scopus 로고
    • Animal-free production of ccc-super- coiled plasmids for research and clinical applications
    • Schleef M, Schmidt T. Animal-free production of ccc-super- coiled plasmids for research and clinical applications. J Gene Med 2004; 6: S45-S53.
    • (2004) J Gene Med , vol.6 , pp. S45-S53
    • Schleef, M.1    Schmidt, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.