Murine cytotoxic T lymphocytes recognize an epitope in an EBNA-1 fragment, but fail to lyse EBNA-1-expressing mouse cells

Journal of Experimental Medicine

Volumn 187, Issue 3, 1998, Pages 445-450

  Mukherjee, Siddhartha ^a   Trivedi, Pankaj ^d   Dorfman, David M ^c   Klein, George ^b   Townsend, Alain ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b KAROLINSKA INSTITUTE   (Sweden)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d IRCCS NEUROMED   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DNA FRAGMENT; EPITOPE; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CYTOTOXIC T LYMPHOCYTE; EPSTEIN BARR VIRUS; GENE DELETION; GENE EXPRESSION; IMMUNOCOMPETENCE; LYMPHOCYTE FUNCTION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; VACCINIA VIRUS; VIRUS INFECTION;

EID: 0032472871     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.187.3.445     Document Type: Article

References (22)

1. Kieff, E. 1996. Epstein Barr virus and its replication. In Virology. B.N. Fields, D.M. Knipe, P. Howley, R. Chanock, J. Melnick, T. Monath, B. Rozman, S.E. Straus, editors. Lippincott-Raven Press, New York. 2243-2396.
2. Klein, G. 1989. Viral latency and transformation: the strategy of Epstein Barr virus. Cell. 58:5-8.
3. Townsend, A., and H. Bodmer. 1989. Antigen recognition by class I-restricted T lymphocytes. Annu. Rev. Immunol. 7:601-624.
4. Khanna, R., S.R. Burrows, M.G. Kurilla, C.A. Jacob, I.S. Misko, T.B. Sculley, E. Kieff, and D.J. Moss. 1992. Localisation of Epstein-Barr virus-specific cytotoxic T cell epitopes using recombinant vaccinia: implications for vaccine development. J. Exp. Med. 176:169-176.
5. Murray, R.J., M.G. Kurilla., J.M. Brooks, W.A. Thomas, M. Rowe, E. Kieff, and A.B. Rickinson. 1992. Identification of target antigens for the human cytotoxic T cell response to Epstein-Barr virus (EBV): implications for immune control of EBV-positive malignanacies. J. Exp. Med 176:157-168.
6. Masucci, M., and I. Ernberg. 1994. Epstein Barr virus: adaptation to a life within the immune system. Trends Microbiol. 2:125-130.
7. Trivedi, P., M.G. Masucci, G. Winberg, and G. Klein. 1991. The Epstein-Barr-virus-encoded membrane protein LMP but not the nuclear antigen EBNA-1 induces rejection of transfected murine mammary carcinoma cells. Int. J. Cancer. 48:794-800.
8. Khanna, R., S.R. Burrows, P.M. Steigerwald-Mullen, S.A. Thomson, M.G. Kurilla, and K.D.J. Moss. 1995. Isolation of cytotoxic T lymphocytes from healthy seropositive individuals specific for peptide epitopes from Epstein-Barr virus nuclear antigen 1: implications for viral persistence and tumor surveillance. Virology. 214:633-637.
9. Levitskaya, J., M. Coram, V. Levitsky, S. Imreh, P.M. Steigerwald-Mullen, G. Klein, M.G. Kurilla, and M.G. Masucci. 1995. Inhibition of antigen presentation by the internal repeat region of the Epstein Barr virus nuclear antigen-1. Nature. 375:685-688.
10. Townsend, A., J. Bastin, K. Gould, G. Brownlee, M. Andrew, B. Coupar, D. Boyle, S. Chan, and G. Smith. 1988. Defective presentation to class I-restricted cytotoxic T lymphocytes in vaccinia-infected cells is overcome by enhanced degradation of antigen. J. Exp. Med. 168:1211-1224.
11. Sternas, L., T. Middleton, and B. Sugden. 1990. The average number of molecules of Epstein-Barr nuclear antigen 1 per cell does not correlate with the average number of Epstein-Barr virus (EBV) DNA molecules per cell among different clones of EBV-immortalized cells. J. Virol. 64:2407-2410.
12. Dillner, J., L. Sternas, B. Kallin, H. Alexander, B. Ehlin-Henriksson, H. Jornvall, G. Klein, and R. Lerner. 1984. Antibodies against a synthetic peptide identify the Epstein-Barr virus-determined nuclear antigen. Proc. Natl. Acad. Sci. USA. 81:4652-4656.
13. Rammensee, H.K.F., and O. Rotzschke. 1993. Peptides naturally presented by MHC class I molecules. Annu. Rev. Immunol. 11:213-244.
14. Sha, W.C., C.A. Nelson, R.D. Newberry, D.M. Kranz, J.H. Russell, and D.Y. Loh. 1988. Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice. Nature. 335:271-274.
15. Stuber, G., J. Dillner, S. Modrow, H. Wolf, L. Szekely, G. Klein, and E. Klein. 1995. HLA-A0201 and HLA B7 binding petides in EBV-encoded EBNA-1, EBNA 2 and BZLF-1 detected in the MHC class I stabilization assay. Int. Immunol. 7:653-663.
16. + T cell responses to EBV EBNA1: HLA class I presentation of the (GLY-ALA) containing protein requires exogenous processing. Immunity. 7: 791-802.
17. Ambinder, R.M., M. Mullen, Y. Chang, G. Hayward, and S.D. Hayward. 1991. Functional domains of Epstein Barr virus nuclear antigen EBNA-1. J. Virol. 65:1466-1478.
18. Cerundolo, V., A. Benham, V. Braud, S. Mukherjee, K. Gould, B. Macino, J. Neefjes, and A. Townsend. 1997. The proteasome-specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells. Eur. J. Immunol. 27:336-341.
19. Yates, J.L., N. Warren, and B. Sugden. 1985. Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cells. Nature. 313:812-815.
20. Chen, F., J.Z. Zou, L. di Renzo, G. Winberg, L.F. Hu, E. Klein, G. Klein, and I. Ernberg. 1995. A subpopulation of normal B cells latently infected with Epstein Barr virus resembles Burkitt lymphoma cells in expressing EBNA-1 but not EBNA-2 or LMP-1. J. Virol. 69:3752-3758.
21. Rooney, C.M., M. Rowe, L.E. Wallace, and A.B. Rickinson. 1985. Epstein-Barr virus positive Burkitt's lymphomas not recognised by virus specific T-cell surveillance. Nature. 317:629-631.
22. Frisan, T., Q.J. Zhang, J. Levitskaya, M. Coram, M.G. Kurilla, and M.G. Masucci. 1996. Detective presentation of MHC class I-restricted cytotoxic T cell epitopes in Burkitt's lymphoma cell. Int. J. Cancer. 68:251-258.