Dissection study on the severe acute respiratory syndrome 3C-like protease reveals the critical role of the extra domain in dimerization of the enzyme. Defining the extra domain as a new target for design of highly specific protease inhibitors

Journal of Biological Chemistry

Volumn 279, Issue 23, 2004, Pages 24765-24773

  Shi, Jiahai ^a   Wei, Zheng ^a   Song, Jianxing ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; DIMERIZATION; ENZYME INHIBITION; LIGHT SCATTERING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE (COMPOSITION);

CIRCULAR-DICHROISM; ENZYME-SUBSTRATE INTERACTIONS;

PROTEINS;

3C LIKE PROTEINASE; PEPTIDE; PROTEINASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; CONCENTRATION (PARAMETERS); CORONAVIRUS; DIMERIZATION; DRUG DESIGN; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; LIGHT SCATTERING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PICORNAVIRUS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; SEVERE ACUTE RESPIRATORY SYNDROME;

CATALYSIS; CHYMOTRYPSIN; CIRCULAR DICHROISM; CLONING, MOLECULAR; CYSTEINE ENDOPEPTIDASES; DIMERIZATION; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPEPTIDASES; ENZYME INHIBITORS; GLUTATHIONE TRANSFERASE; LIGHT; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PEPTIDES; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; SCATTERING, RADIATION; TEMPERATURE; TIME FACTORS; VIRAL PROTEINS;

CORONAVIRUS; PICORNAVIRIDAE; RNA VIRUSES;

EID: 2642545063     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M311744200     Document Type: Article

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