Severe acute respiratory syndrome coronavirus 3C-like proteinase N terminus is indispensable for proteolytic activity but not for enzyme dimerization: Biochemical and thermodynamic investigation in conjunction with molecular dynamics simulations

Journal of Biological Chemistry

Volumn 280, Issue 1, 2005, Pages 164-173

  Chen, Shuai ^a   Chen, Lili ^a   Tan, Jinzhi ^a   Chen, Jing ^a   Du, Li ^a   Sun, Tao ^a   Shen, Jianhua ^a   Chen, Kaixian ^a   Jiang, Hualiang ^a   Shen, Xu ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; DIMERIZATION; DRUG PRODUCTS; ENERGY TRANSFER; FLUORESCENCE; MOLECULAR DYNAMICS; PROTEINS; RESONANCE; SIZE EXCLUSION CHROMATOGRAPHY; THERMODYNAMICS; TITRATION;

DOCKING SIMULATIONS; ISOTHERMAL TITRATION CALORIMETERS; SEVERE ACUTE RESPIRATORY SYNDROME (SARS); VIRAL REPLICATION;

ENZYMES;

GLUTARALDEHYDE; PROTEINASE; VIRUS PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; CROSS LINKING; DIMERIZATION; DISSOCIATION CONSTANT; ENZYME ACTIVITY; FLUORESCENCE RESONANCE ENERGY TRANSFER; GEL PERMEATION CHROMATOGRAPHY; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR DYNAMICS; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; SARS CORONAVIRUS; SIMULATION; THERMODYNAMICS;

BINDING SITES; CALORIMETRY; CYSTEINE ENDOPEPTIDASES; DIMERIZATION; ENDOPEPTIDASES; ENERGY TRANSFER; PROMOTER REGIONS (GENETICS); PROTEIN CONFORMATION; SARS VIRUS; SUBSTRATE SPECIFICITY; THERMODYNAMICS; VIRAL PROTEINS;

CORONAVIRUS; RNA VIRUSES; SARS CORONAVIRUS;

EID: 12844272193     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M408211200     Document Type: Article

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