Huntingtin is cleaved by caspases in the cytoplasm and translocated to the nucleus via perinuclear sites in Huntington's disease patient lymphoblasts

Neurobiology of Disease

Volumn 20, Issue 2, 2005, Pages 267-274

  Sawa, Akira ^a   Nagata, Eiichiro ^a   Sutcliffe, Siobhan ^a   Dulloor, Pratima ^a   Cascio, Matthew B ^a   Ozeki, Yuji ^a   Roy, Sophie ^b   Ross, Christopher A ^a   Snyder, Solomon H ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Merck Canada Co Ltd   (Canada)

Author keywords

Caspase; Cleavage; Htt; Huntington's disease; Perinuclear site

Indexed keywords

CASPASE; HUNTINGTIN;

AMINO TERMINAL SEQUENCE; ARTICLE; AUTOPSY; CLUSTER ANALYSIS; CONTROLLED STUDY; CYTOPLASM; DNA CLEAVAGE; GENE TRANSLOCATION; HUMAN; HUMAN CELL; HUMAN TISSUE; HUNTINGTON CHOREA; LYMPHOBLAST; PRIORITY JOURNAL;

ACTIVE TRANSPORT, CELL NUCLEUS; APOPTOSIS; CASPASES; CELL NUCLEUS; CELLS, CULTURED; CYTOPLASM; HUMANS; HUNTINGTON DISEASE; LYMPHOCYTES; MICROSCOPY, ELECTRON, TRANSMISSION; MUTATION; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; STEM CELLS;

EID: 26944478180     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2005.02.013     Document Type: Article

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