Molecular determinants of multi-nucleoside analogue resistance in HIV-1 reverse transcriptases containing a dipeptide insertion in the fingers subdomain. Effect of mutations D67N and T215Y on removal of thymidine nucleotide analogues from blocked DNA primers

Journal of Biological Chemistry

Volumn 279, Issue 23, 2004, Pages 24569-24577

  Matamoros, Tania ^a   Franco, Sandra ^b   Vázquez Álvarez, Blanca M ^a   Mas, Antonio ^a,c   Ángel Martínez, Miguel ^b   Menéndez Arias, Luis ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

^c UNIVERSITAT POMPEU FABRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DRUG PRODUCTS; ENZYMES; MOLECULAR BIOLOGY;

IMMUNODEFICIENCY; MUTATION;

BIOCHEMISTRY;

ADENOSINE TRIPHOSPHATE; ASPARAGINE; DEOXYRIBONUCLEOSIDE TRIPHOSPHATE; DIPEPTIDE; NUCLEOSIDE ANALOG; PYROPHOSPHATE; RNA DIRECTED DNA POLYMERASE; SERINE; STAVUDINE; THREONINE; THYMIDINE DERIVATIVE; TYROSINE; ZIDOVUDINE;

AMINO ACID SUBSTITUTION; ARTICLE; CODON; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; GENE INSERTION; HUMAN IMMUNODEFICIENCY VIRUS 1; MULTIDRUG RESISTANCE; MUTATION; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; SENSITIZATION;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; BASE SEQUENCE; CODON; DNA; DNA PRIMERS; DRUG RESISTANCE, VIRAL; GENE DELETION; HIV-1 REVERSE TRANSCRIPTASE; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDES; PHENOTYPE; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; REVERSE TRANSCRIPTASE INHIBITORS; SEQUENCE HOMOLOGY, AMINO ACID; STAVUDINE; THYMIDINE; TIME FACTORS; TYROSINE; ZIDOVUDINE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; INSERTION SEQUENCES; RNA VIRUSES;

EID: 2642518791     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M312658200     Document Type: Article

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