Probing the molecular mechanisms of AZT drug resistance mediated by HIV-1 reverse transcriptase using a transient kinetic analysis

Biochemistry

Volumn 42, Issue 29, 2003, Pages 8831-8841

  Ray, Adrian S ^a   Murakami, Eisuke ^a   Basavapathruni, Aravind ^a   Vaccaro, Joseph A ^a,d   Ulrich, Dagny ^a   Chu, Chung K ^b   Schinazi, Raymond F ^c   Anderson, Karen S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DRUG PRODUCTS; RNA; SYNTHESIS (CHEMICAL); VIRUSES;

DRUG RESISTANCE;

BIOCHEMISTRY;

2',3' DIDEOXYNUCLEOSIDE DERIVATIVE; ADENOSINE TRIPHOSPHATE; DNA; PHOSPHOROTHIOIC ACID DERIVATIVE; PYROPHOSPHATE; RNA; RNA DIRECTED DNA POLYMERASE; ZIDOVUDINE;

ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; DRUG MECHANISM; DRUG SENSITIVITY; ENZYME ACTIVE SITE; ENZYME KINETICS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PRIORITY JOURNAL; VIRUS REPLICATION;

ADENOSINE TRIPHOSPHATE; ANTI-HIV AGENTS; BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, VIRAL; HIV-1 REVERSE TRANSCRIPTASE; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, CHEMICAL; MUTATION; PROTEIN BINDING; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; ZIDOVUDINE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0042347690     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034435l     Document Type: Article

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