Stable rearrangements of the β3-β4 hairpin loop of HIV-1 reverse transcriptase in plasma viruses from patients receiving combination therapy

AIDS

Volumn 12, Issue 14, 1998, Pages

  Tamalet, Catherine ^a   Izopet, Jacques ^b   Koch, Nathalie ^a   Fantini, Jacques ^c   Yahi, Nouara ^a  

^a TIMONE HOSPITAL   (France)

^b CHU PURPAN   (France)

^c AIX MARSEILLE UNIVERSITY   (France)

Author keywords

Deletions; Insertions; Processivity; Rearrangement; Reverse transcriptase

Indexed keywords

ANTIVIRUS AGENT; DIDANOSINE; FLUORESCENT DYE; INDINAVIR; LAMIVUDINE; NELFINAVIR; NEVIRAPINE; RITONAVIR; RNA DIRECTED DNA POLYMERASE; SAQUINAVIR; STAVUDINE; VIRUS ENZYME; ZALCITABINE; ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; VIRUS RNA;

ARTICLE; FOLLOW UP; GENE DELETION; GENE INSERTION; GENE REARRANGEMENT; GENE SEQUENCE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; AMINO ACID SEQUENCE; CHEMISTRY; DNA SEQUENCE; DRUG COMBINATION; ENZYMOLOGY; GENETICS; ISOLATION AND PURIFICATION; METHODOLOGY; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PROTEIN SECONDARY STRUCTURE; VIREMIA; VIROLOGY; VIRUS GENE; VIRUS LOAD;

AMINO ACID SEQUENCE; ANTI-HIV AGENTS; BASE SEQUENCE; DRUG THERAPY, COMBINATION; GENE DELETION; GENE REARRANGEMENT; GENES, VIRAL; HIV INFECTIONS; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; PROTEIN STRUCTURE, SECONDARY; RNA, VIRAL; SEQUENCE ANALYSIS, DNA; VIRAL LOAD; VIREMIA;

EID: 0032189068     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199814000-00003     Document Type: Article

References (16)

1. Beard WA, Wilson SH: Reverse transcriptase. In HIV: A Practical Approach. Volume 2: Biochemistry, Molecular Biology and Drug Discovery. Edited by Karn J. Oxford: IRL Press; 1995:15-36.
2. Kohlstaedt LA, Wang J, Friedman JM, Rice PA, Steitz TA: Crystal structure at 3.5 Å resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science 1992, 256:1783-1790.
3. Jacob-Molina A, Ding J, Nanni RG, et al.: Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 Å resolution shows bent DNA. Proc Natl Acad Sci USA 1993, 90:6320-6324.
4. Temin HM: Retrovirus variation and reverse transcription: abnormal strand transfers result in retrovirus genetic variation. Proc Natl Acad Sci USA 1993, 90:6900-6903.
5. Coffin JM: HIV population dynamics in vivo. Science 1995, 267:483-489.
6. Nijhuis M, Boucher CAB, Schuurman R: Sensitive procedure for the amplification of HIV-1 RNA using combined reverse transcription and amplification reaction. Biotechniques 1995, 19:178-180.
7. Jung M, Agut H, Candolli D, Ingrand D, Katlama C, Huraux JM: Susceptibility of HIV-1 isolates to zidovudine: correlation between widely applicable culture test and PCR analysis. J Acquir Immune Defic Syndr 1992, 5:359-364.
8. King RD: Prediction of secondary structure. In Protein Structure Prediction: A Practical Approach. Edited by Sternberg MJE. Oxford: IRL Press; 1996:79-99.
9. Arnold E, Ding J, Hughes SH, Hostomsky Z: Structures of DNA and RNA polymerases and their interactions with nucleic acid substrates. Curr Opin Struct Biol 1995, 5:27-38.
10. Tantillo C, Ding J, Jacob-Molina A, et al.: Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase: implications for mechanisms of drug inhibition and resistance. J Mol Biol 1994, 243:369-387.
11. Arion D, Borkow G, Gu Z, Wainberg MA, Parniak MA: The K65R mutation confers increased DNA polymerase processivity to HIV-1 reverse transcriptase. J Biol Chem 1996, 271:19860-19864.
12. Kew Y, Olsen LR, Japour AJ, Prasad VR: Insertions into the β3-β4 hairpin loop of HIV-1 reverse transcriptase reveal a role for fingers subdomain in processive polymerization. J Biol Chem 1998, 273:7529-7537.
13. Ross L, Johnson M, Graham N, Shaefer M, Griswold M, St Clair M: In-frame insertions and deletions in the HIV RT coding region between aa 67 and 69 are associated with a decreased patient viral load. Fifth Conference on Retroviruses and Opportunistic Infections. Chicago, February 1998 [abstract 639].
14. Avidan O, Hizi A: The processivity of DNA synthesis exhibited by drug-resistant variants of human immunodeficiency virus type-1 reverse transcriptase. Nucleic Acids Res 1998, 26:1713-1717.
15. Boyer PL, Hughes SH: Analysis of mutations at position 184 in reverse transcriptase of human immunodeficiency virus type 1. Antimicrob Agents Chemother 1995, 39:1624-1628.
16. Caliendo AM, Savara A, An D, De Vore K, Kaplan JC, D'Aquila RT: Effects of zidovudine-selected human immunodeficiency virus type 1 reverse transcriptase amino acid substitutions on processive DNA synthesis and viral replication. J Virol 1996, 70:2146-2153.