Genotypic, phenotypic, and modeling studies of a deletion in the β3-β4 region of the human immunodeficiency virus type 1 reverse transcriptase gene that is associated with resistance to nucleoside reverse transcriptase inhibitors

Journal of Virology

Volumn 74, Issue 22, 2000, Pages 10707-10713

  Winters, M A ^a   Coolley, K L ^a   Cheng, P ^a   Girard, Y A ^a   Hamdan, H ^a   Kovari, L C ^a   Merigan, T C ^a  

^a STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADEFOVIR; EFAVIRENZ; LAMIVUDINE; NEVIRAPINE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; ZIDOVUDINE;

AMINO ACID SEQUENCE; ARTICLE; CLINICAL ARTICLE; DELETION MUTANT; DRUG RESISTANCE; DRUG SENSITIVITY; GENE DELETION; GENE INSERTION; GENOTYPE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; MODEL; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; VIRUS GENE;

DRUG RESISTANCE, MICROBIAL; GENOTYPE; HIV INFECTIONS; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; MODELS, MOLECULAR; PHENOTYPE; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; REVERSE TRANSCRIPTASE INHIBITORS; SEQUENCE ALIGNMENT; SEQUENCE DELETION; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0033760936     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.22.10707-10713.2000     Document Type: Article

References (32)

1. Lamivudine-resistant HIV-1 clinical isolates lacking the Met184Val mutation have novel polymorphisms in RT
2. Analysis of amino insertion mutations in the fingers subdomain of HIV-1 reverse transcriptase
3. Antiretroviral therapy in adults: Updated recommendations of the international AIDS society-USA panel
4. Algorithm for ribbon models of proteins
5. Mutations in the pol gene of human immunodeficiency virus type 1 in infected patients receiving didanosine and hydroxyurea combination therapy
6. A novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine
7. Antiretroviral drug resistance testing in adults with HIV infection: Implications for clinical management
8. Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: Implications for resistance
9. High-level resistance to 3'-azido-3'-deoxythymidine due to a deletion in the reverse transcriptase gene of human immunodeficiency virus type 1
10. Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 Å resolution shows bent DNA
11. Standardized peripheral blood mononuclear cell culture assay for determination of drug susceptibilities of clinical human immunodeficiency virus type 1 isolates
12. Improved methods for building protein models in electron density maps and the location of errors in these models
13. HIV with reduced sensitivity to zidovudine isolated during prolonged therapy
14. Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy
15. A family of insertion mutations between codons 67 and 70 of human immunodeficiency virus type 1 reverse transcriptase confer multinucleoside analog resistance
16. Comparative protein structure modeling of genes and genomes
17. Prevalence and incidence of resistance to zidovudine and other antiretroviral drugs
18. Domain flexibility in retroviral proteases: Structural implications for drug resistant mutations
19. Evaluation of comparative protein modeling by MODELLER
20. Comparative protein modelling by satisfaction of spatial restraints
21. Large-scale protein structure modeling of the Saccharomyces cerevisiae genome
22. Mutations in retroviral genes associated with drug resistance
23. Drug resistance and heterogeneous long-term virologic responses of human immunodeficiency virus type 1-infected subjects to zidovudine and didanosine combination therapy
24. Genotypic and phenotypic changes during culture of a multinucleoside-resistant human immunodeficiency virus type 1 strain in the presence and absence of additional reverse transcriptase inhibitors
25. Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides
26. Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase
27. Stable rearrangements of the β3-β4 hairpin loop of HIV-1 reverse transcriptase in plasma viruses from patients receiving combination therapy
28. Locations of anti-AIDS drug binding sites and resistance mutations in the three dimensional structure of HIV-1 RT
29. Rapid in vitro selection of human immunodeficiency virus type 1 resistance to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase
30. LIGPLOT: A program to generate schematic diagrams of protein-ligand interactions
31. A 6-basepair deletion in the reverse transcriptase gene of HIV-1 confers resistance to multiple nucleoside inhibitors