-
1
-
-
0029011730
-
Toward improved anti-HIV chemotherapy: Therapeutic strategies for intervention with HIV infections
-
De Clercq E. 1995. Toward improved anti-HIV chemotherapy: therapeutic strategies for intervention with HIV infections. J. Med. Chem. 38:2491-517
-
(1995)
J. Med. Chem.
, vol.38
, pp. 2491-2517
-
-
De Clercq, E.1
-
2
-
-
0028874048
-
Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
-
Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M. 1995. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373:123-26
-
(1995)
Nature
, vol.373
, pp. 123-126
-
-
Ho, D.D.1
Neumann, A.U.2
Perelson, A.S.3
Chen, W.4
Leonard, J.M.5
Markowitz, M.6
-
3
-
-
0028811974
-
Viral dynamics in human immunodeficiency virus type 1 infection
-
Wei X, Ghosh SK, Taylor ME, Johnson VA, Emini EA, et al. 1995. Viral dynamics in human immunodeficiency virus type 1 infection. Nature 373:117-22
-
(1995)
Nature
, vol.373
, pp. 117-122
-
-
Wei, X.1
Ghosh, S.K.2
Taylor, M.E.3
Johnson, V.A.4
Emini, E.A.5
-
4
-
-
0028952146
-
HIV population dynamics in vivo: Implications for genetic variation, pathogenesis and therapy
-
Coffin JM. 1995. HIV population dynamics in vivo: implications for genetic variation, pathogenesis and therapy. Science 267:483-89
-
(1995)
Science
, vol.267
, pp. 483-489
-
-
Coffin, J.M.1
-
6
-
-
0028158211
-
Resistance of human immunodeficiency virus type 1 to antiretroviral agents: A review
-
Erice A, Balfour HH Jr. 1994. Resistance of human immunodeficiency virus type 1 to antiretroviral agents: a review. Clin. Infect. Dis. 18:149-56
-
(1994)
Clin. Infect. Dis.
, vol.18
, pp. 149-156
-
-
Erice, A.1
Balfour Jr., H.H.2
-
7
-
-
0028018286
-
Resistance, drug failure, and disease progression
-
Richman DD. 1994. Resistance, drug failure, and disease progression. AIDS Res. Hum. Retroviruses 10:901-5
-
(1994)
AIDS Res. Hum. Retroviruses
, vol.10
, pp. 901-905
-
-
Richman, D.D.1
-
8
-
-
0028120730
-
HIV resistance to reverse transcriptase inhibitors
-
De Clercq E. 1994. HIV resistance to reverse transcriptase inhibitors. Biochem. Pharmacol. 47:155-69
-
(1994)
Biochem. Pharmacol.
, vol.47
, pp. 155-169
-
-
De Clercq, E.1
-
9
-
-
0028250506
-
The genetic and functional basis of HIV-1 resistance to nonnucleoside reverse transcriptase inhibitors
-
Emini EA, Byrnes VW, Condra JH, Schleif WA, Sardana VV. 1994. The genetic and functional basis of HIV-1 resistance to nonnucleoside reverse transcriptase inhibitors. Arch. Virol. 9:11-17
-
(1994)
Arch. Virol.
, vol.9
, pp. 11-17
-
-
Emini, E.A.1
Byrnes, V.W.2
Condra, J.H.3
Schleif, W.A.4
Sardana, V.V.5
-
10
-
-
9344251454
-
Targeting HIV reverse transcriptase for antiviral drug design against AIDS
-
In press
-
Arnold A, Das K, Ding J, Yadav P, Boyer PL, Hughes SH. 1995. Targeting HIV reverse transcriptase for antiviral drug design against AIDS. Drug Des. Dis. In press
-
(1995)
Drug Des. Dis.
-
-
Arnold, A.1
Das, K.2
Ding, J.3
Yadav, P.4
Boyer, P.L.5
Hughes, S.H.6
-
11
-
-
0026693137
-
Crystal structure at 3.5 Å resolution of HIV-1 reverse transcriptase complexed with an inhibitor
-
Kohlstaedt LA, Wang J, Friedman JM, Rice PA, Steitz TA. 1992. Crystal structure at 3.5 Å resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science 256:1783-90
-
(1992)
Science
, vol.256
, pp. 1783-1790
-
-
Kohlstaedt, L.A.1
Wang, J.2
Friedman, J.M.3
Rice, P.A.4
Steitz, T.A.5
-
12
-
-
0027318776
-
Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 Å resolution shows bent DNA
-
Jacobo-Molina A, Ding JP, Nanni RG, Clark AD Jr, Lu XD, et al. 1993. Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 Å resolution shows bent DNA. Proc. Natl. Acad. Sci. USA 90:6320-24
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 6320-6324
-
-
Jacobo-Molina, A.1
Ding, J.P.2
Nanni, R.G.3
Clark Jr., A.D.4
Lu, X.D.5
-
13
-
-
0028842293
-
The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1
-
Rodgers DW, Gamblin SJ, Harris BA, Ray S, Culp JS, et al. 1995. The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA 92:1222-26
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 1222-1226
-
-
Rodgers, D.W.1
Gamblin, S.J.2
Harris, B.A.3
Ray, S.4
Culp, J.S.5
-
14
-
-
0028947588
-
High resolution structures of HIV-1 RT from four RT-inhibitor complexes
-
Ren J, Esnouf R, Garman E, Somers D, Ross C, et al. 1995. High resolution structures of HIV-1 RT from four RT-inhibitor complexes. Nat. Struct. Biol. 2:293-302
-
(1995)
Nat. Struct. Biol.
, vol.2
, pp. 293-302
-
-
Ren, J.1
Esnouf, R.2
Garman, E.3
Somers, D.4
Ross, C.5
-
15
-
-
0029644484
-
Structure of HIV-1 reverse transcriptase in a complex with the nonnucleoside inhibtor α-APA R 95845 at 2.8 Å resolution
-
Ding JP, Das K, Tantillo C, Zhang W, Clark AD Jr, et al. 1995. Structure of HIV-1 reverse transcriptase in a complex with the nonnucleoside inhibtor α-APA R 95845 at 2.8 Å resolution. Structure 3:365-79
-
(1995)
Structure
, vol.3
, pp. 365-379
-
-
Ding, J.P.1
Das, K.2
Tantillo, C.3
Zhang, W.4
Clark Jr., A.D.5
-
16
-
-
0029075207
-
Structure of HIV-1 RT/TBIO R 86183 complex reveals similarity in the bindng of diverse nonnucleoside inhibitors
-
Ding J, Das K, Moereels H, Koymans L, Andries K, et al. 1995. Structure of HIV-1 RT/TBIO R 86183 complex reveals similarity in the bindng of diverse nonnucleoside inhibitors. Struct. Biol. 2:407-15
-
(1995)
Struct. Biol.
, vol.2
, pp. 407-415
-
-
Ding, J.1
Das, K.2
Moereels, H.3
Koymans, L.4
Andries, K.5
-
17
-
-
0005374817
-
An electronic characterization of a congeneric series of nevirapine analogs
-
Pattabiraman N, Gussio R, Topol I, Burt SK, Erickson JW. 1994. An electronic characterization of a congeneric series of nevirapine analogs. Abstr. Pap. ACS 208:33
-
(1994)
Abstr. Pap. ACS
, vol.208
, pp. 33
-
-
Pattabiraman, N.1
Gussio, R.2
Topol, I.3
Burt, S.K.4
Erickson, J.W.5
-
18
-
-
0028924567
-
Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleosiide inhibitors
-
Esnouf R, Ren J, Ross C, Jones Y, Stammers D, Stuart D. 1995. Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleosiide inhibitors. Nat. Struct. Biol. 2:303-8
-
(1995)
Nat. Struct. Biol.
, vol.2
, pp. 303-308
-
-
Esnouf, R.1
Ren, J.2
Ross, C.3
Jones, Y.4
Stammers, D.5
Stuart, D.6
-
19
-
-
0028925773
-
Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors
-
Spence RA, Kati WM, Anserson KS, Johnson KA. 1995. Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors. Science 267:988-93
-
(1995)
Science
, vol.267
, pp. 988-993
-
-
Spence, R.A.1
Kati, W.M.2
Anserson, K.S.3
Johnson, K.A.4
-
20
-
-
0028855166
-
Mutations in HIV-1 reverse transcriptase and protease associated with drug resistance
-
Mellors JW, Larder BA, Schinazi RF. 1995. Mutations in HIV-1 reverse transcriptase and protease associated with drug resistance. Int. Antivir. News 3:8-13
-
(1995)
Int. Antivir. News
, vol.3
, pp. 8-13
-
-
Mellors, J.W.1
Larder, B.A.2
Schinazi, R.F.3
-
21
-
-
0028096227
-
Modulation of HIV-1 reverse transcriptase function in "selectively deleted" p66/p51 heterodimers
-
Jacques PS, Wohrl BM, Howard KJ, Le Grice SFJ. 1994. Modulation of HIV-1 reverse transcriptase function in "selectively deleted" p66/p51 heterodimers. J. Biol. Chem. 269:1388-93
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 1388-1393
-
-
Jacques, P.S.1
Wohrl, B.M.2
Howard, K.J.3
Le Grice, S.F.J.4
-
22
-
-
0027472841
-
A single conservative amino acid substitution in the reverse transcriptase of human immunodeficiency virus-1 confers resistance to (+)-(5S)-4,5,6,7-tetrahydro-5-methyl-6-(3-methyl-2-butenyl) imidazo [4,5,1-jk] [1,4]benzodiazepin-2 (1H)-thione (TIBO R82150)
-
Mellors JW, Im GJ, Tramontano E, Winkler SR, Medina DJ, et al. 1993. A single conservative amino acid substitution in the reverse transcriptase of human immunodeficiency virus-1 confers resistance to (+)-(5S)-4,5,6,7-tetrahydro-5-methyl-6-(3-methyl-2-butenyl) imidazo [4,5,1-jk] [1,4]benzodiazepin-2 (1H)-thione (TIBO R82150). Mol. Pharmacol. 43:1-16
-
(1993)
Mol. Pharmacol.
, vol.43
, pp. 1-16
-
-
Mellors, J.W.1
Im, G.J.2
Tramontano, E.3
Winkler, S.R.4
Medina, D.J.5
-
23
-
-
0027209906
-
Comprehensive mutant enzyme and viral variant assesment of human immunodeficiency virus type-1 reverse transcriptase resistance to non-nucleoside inhibitors
-
Byrnes BW, Sardana W, Schlief WA, Condra JH, Waterbury JA, et al. 1993. Comprehensive mutant enzyme and viral variant assesment of human immunodeficiency virus type-1 reverse transcriptase resistance to non-nucleoside inhibitors. Antimicrob. Agents Chemother. 37:1576-79
-
(1993)
Antimicrob. Agents Chemother.
, vol.37
, pp. 1576-1579
-
-
Byrnes, B.W.1
Sardana, W.2
Schlief, W.A.3
Condra, J.H.4
Waterbury, J.A.5
-
24
-
-
0027328082
-
HIV-1-specific reverse transcriptase inhibitors show differential activity against HIV-1 mutant strains containing different amino acids substitutions in the reverse transcriptase
-
Balzarini J, Karlsson A, Perez-Perez M-J, Vrang L, Walbers J, et al. 1993. HIV-1-specific reverse transcriptase inhibitors show differential activity against HIV-1 mutant strains containing different amino acids substitutions in the reverse transcriptase. Virology 192:246-53
-
(1993)
Virology
, vol.192
, pp. 246-253
-
-
Balzarini, J.1
Karlsson, A.2
Perez-Perez, M.-J.3
Vrang, L.4
Walbers, J.5
-
25
-
-
0027231438
-
A mutation in reverse transcriptase of bis(heteroaryl)piperazine-resistant human immunodeficiency virus type 1 that confers increased sensitivity to other non-nucleoside inhibitors
-
Dueweke TJ, Pushkarskaya T, Poppe SM, Swaney SM, Zhao Q, et al. 1993. A mutation in reverse transcriptase of bis(heteroaryl)piperazine-resistant human immunodeficiency virus type 1 that confers increased sensitivity to other non-nucleoside inhibitors. Proc. Natl. Acad. Sci. USA 90:4713-17
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 4713-4717
-
-
Dueweke, T.J.1
Pushkarskaya, T.2
Poppe, S.M.3
Swaney, S.M.4
Zhao, Q.5
-
26
-
-
0027524005
-
Human immunodeficiency virus type 1-specific [2′,5′bis-O-(tetrabutyl-dimethylsilyl) - β - D - ribofuranosyl]-3′-spiro -5- (4) amino-1′,2′-oxathiole-2′,2′-doxide-purine analogues show a resistance spectrum that is different from that of the human immunodeficiency virus type 1-specfic nononucleoside analogues
-
Balzarini J, Velazquez S, San-Felix A, Karlsson A, Perez-Perez M-J, et al. 1993. Human immunodeficiency virus type 1-specific [2′,5′bis-O-(tetrabutyl-dimethylsilyl) - β - D - ribofuranosyl]-3′-spiro -5- (4) amino-1′,2′-oxathiole-2′,2′-doxide)-purine analogues show a resistance spectrum that is different from that of the human immunodeficiency virus type 1-specfic nononucleoside analogues. Mol. Pharmacol. 43:109-14
-
(1993)
Mol. Pharmacol.
, vol.43
, pp. 109-114
-
-
Balzarini, J.1
Velazquez, S.2
San-Felix, A.3
Karlsson, A.4
Perez-Perez, M.-J.5
-
27
-
-
0028329899
-
Identification of novel mutations that confer drug resistance in the human immunodeficiency virus polymerase gene
-
Gu ZG, Gao Q, Fang HS, Parniak MA, Brenner BG, Wainberg MA. 1994. Identification of novel mutations that confer drug resistance in the human immunodeficiency virus polymerase gene. Leukemia 8(Suppl. 1):5166-69
-
(1994)
Leukemia
, vol.8
, Issue.1 SUPPL.
, pp. 5166-5169
-
-
Gu, Z.G.1
Gao, Q.2
Fang, H.S.3
Parniak, M.A.4
Brenner, B.G.5
Wainberg, M.A.6
-
28
-
-
0028341306
-
Sensitivity of wild-type human immunodeficiency virus type 1 reverse transcriptase to dideoxynucleotides depends on template length: The sensitivity of drug-resistant mutants does not
-
Boyer PL, Tantillo C, Jacobo-Molina A, Nanni RG, Ding JP, et al. 1994. Sensitivity of wild-type human immunodeficiency virus type 1 reverse transcriptase to dideoxynucleotides depends on template length: the sensitivity of drug-resistant mutants does not. Proc. Natl. Acad. Sci. USA 91:4882-86
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 4882-4886
-
-
Boyer, P.L.1
Tantillo, C.2
Jacobo-Molina, A.3
Nanni, R.G.4
Ding, J.P.5
-
29
-
-
0028900977
-
Nucleoside drug resistance in HIV-1 reverse transcriptase
-
Yadav PNS, Yadav JS, Modak MJ. 1994. Nucleoside drug resistance in HIV-1 reverse transcriptase. Nat. Struct. Biol. 2:193-95
-
(1994)
Nat. Struct. Biol.
, vol.2
, pp. 193-195
-
-
Yadav, P.N.S.1
Yadav, J.S.2
Modak, M.J.3
-
30
-
-
0028172345
-
Locations of anti-AIDS drug-binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase
-
Tantillo C, Ding JP, Jacobo-Molina A, Nanni RG, Boyer PL, et al. 1994. Locations of anti-AIDS drug-binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. J. Mol. Biol. 243:369-87
-
(1994)
J. Mol. Biol.
, vol.243
, pp. 369-387
-
-
Tantillo, C.1
Ding, J.P.2
Jacobo-Molina, A.3
Nanni, R.G.4
Boyer, P.L.5
-
31
-
-
0025950055
-
Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase
-
St. Clair MH, Martin JL, Tudor-Williams G, Bach MC, Vavro CL, et al. 1991. Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase. Science 253:1557-59
-
(1991)
Science
, vol.253
, pp. 1557-1559
-
-
St. Clair, M.H.1
Martin, J.L.2
Tudor-Williams, G.3
Bach, M.C.4
Vavro, C.L.5
-
32
-
-
0026579208
-
The HIV-1 protease as a therapeutic target for AIDS
-
Debouck C 1992. The HIV-1 protease as a therapeutic target for AIDS. AIDS Res. Hum. Retroviruses 8:153-64
-
(1992)
AIDS Res. Hum. Retroviruses
, vol.8
, pp. 153-164
-
-
Debouck, C.1
-
33
-
-
0005241362
-
Active human immunodeficiency virus protease is required for viral infectivity
-
Kohl NE, Emini EA, Schleif WA, Davis LJ, Heimbach JC, et al. 1988. Active human immunodeficiency virus protease is required for viral infectivity. Proc. Natl. Acad. Sci. USA 85:4686-90
-
(1988)
Proc. Natl. Acad. Sci. USA
, vol.85
, pp. 4686-4690
-
-
Kohl, N.E.1
Emini, E.A.2
Schleif, W.A.3
Davis, L.J.4
Heimbach, J.C.5
-
34
-
-
0001650127
-
Human immunodeficiency virus has an aspartic-type protease that can be inhibited by pepstatin A
-
Seelmeier S, Schmidt H, Turk V, von der Helm K. 1988. Human immunodeficiency virus has an aspartic-type protease that can be inhibited by pepstatin A. Proc. Natl. Acad. Sci. USA 85:6612-16
-
(1988)
Proc. Natl. Acad. Sci. USA
, vol.85
, pp. 6612-6616
-
-
Seelmeier, S.1
Schmidt, H.2
Turk, V.3
Von Der Helm, K.4
-
35
-
-
0025099016
-
A synthetic HIV-1 protease inhibitor with antiviral activity arrests HIV-like particle maturation
-
McQuade TJ, Tomasselli AG, Liu L, Karacostas V, Moss B, et al. 1990. A synthetic HIV-1 protease inhibitor with antiviral activity arrests HIV-like particle maturation. Science 247:454-56
-
(1990)
Science
, vol.247
, pp. 454-456
-
-
McQuade, T.J.1
Tomasselli, A.G.2
Liu, L.3
Karacostas, V.4
Moss, B.5
-
36
-
-
0001903028
-
The complexities of AIDS: An assessment of the HIV protease as a therapeutic target
-
Tomasselli AG, Howe WJ, Sawyer TK, Wlodawer A, Heinrikson RL 1991. The complexities of AIDS: an assessment of the HIV protease as a therapeutic target. Chim. Oggi 9:6-27
-
(1991)
Chim. Oggi
, vol.9
, pp. 6-27
-
-
Tomasselli, A.G.1
Howe, W.J.2
Sawyer, T.K.3
Wlodawer, A.4
Heinrikson, R.L.5
-
37
-
-
0025952925
-
HIV protease: A novel chemotherapeutic target for AIDS
-
Huff JR. 1991. HIV protease: a novel chemotherapeutic target for AIDS. J. Med. Chem. 34:2305-14
-
(1991)
J. Med. Chem.
, vol.34
, pp. 2305-2314
-
-
Huff, J.R.1
-
38
-
-
0026695235
-
Inhibitors of HIV-1 protease
-
Meek TD. 1992. Inhibitors of HIV-1 protease. J. Enzym. Inhib. 6:65-98
-
(1992)
J. Enzym. Inhib.
, vol.6
, pp. 65-98
-
-
Meek, T.D.1
-
39
-
-
0028248489
-
HIV protease as an inhibitor target for the treatment of AIDS
-
Darke PL, Huff JR 1994. HIV protease as an inhibitor target for the treatment of AIDS. Adv. Pharmacol. 25:399-455
-
(1994)
Adv. Pharmacol.
, vol.25
, pp. 399-455
-
-
Darke, P.L.1
Huff, J.R.2
-
40
-
-
9344224916
-
Characterisation of in vivo selected HIV-1 variants with reduced sensitivity to proteinase inhibitor Saquinavir
-
Yokohama, Jpn. Abstr.
-
Mous J, Brun-Vezinet F, Duncan IB, Hanggi M, Jacobsen H, Vella S. 1994. Characterisation of in vivo selected HIV-1 variants with reduced sensitivity to proteinase inhibitor Saquinavir. 10th Int. Conf. AIDS STD, Yokohama, Jpn. p. 515B (Abstr.)
-
(1994)
10th Int. Conf. AIDS STD
-
-
Mous, J.1
Brun-Vezinet, F.2
Duncan, I.B.3
Hanggi, M.4
Jacobsen, H.5
Vella, S.6
-
41
-
-
0029157399
-
The not-so-great escape
-
Erickson JW. 1995. The not-so-great escape. Nat. Struct. Biol. 2:523-29
-
(1995)
Nat. Struct. Biol.
, vol.2
, pp. 523-529
-
-
Erickson, J.W.1
-
42
-
-
0027218692
-
Structure-based inhibitors of HIV-1 protease
-
Wlodawer A, Erickson JW. 1993. Structure-based inhibitors of HIV-1 protease. Annu. Rev. Biochem. 62:543-85
-
(1993)
Annu. Rev. Biochem.
, vol.62
, pp. 543-585
-
-
Wlodawer, A.1
Erickson, J.W.2
-
43
-
-
0028958868
-
Flap opening in HIV-1 protease simulated by 'activated' molecular dynamics
-
Collins JR, Burt SK, Erickson JW. 1995. Flap opening in HIV-1 protease simulated by 'activated' molecular dynamics. Nat. Struct. Biol. 2:334-38
-
(1995)
Nat. Struct. Biol.
, vol.2
, pp. 334-338
-
-
Collins, J.R.1
Burt, S.K.2
Erickson, J.W.3
-
44
-
-
16044375105
-
Crystal structures of HIV-1 protease-inhibitor complexes
-
Appelt K. 1993. Crystal structures of HIV-1 protease-inhibitor complexes. Perspect. Drug Dis. Des. 1:23-48
-
(1993)
Perspect. Drug Dis. Des.
, vol.1
, pp. 23-48
-
-
Appelt, K.1
-
46
-
-
0027507716
-
Inhibitors of aspartyl proteinases
-
Abdel-Meguid SS. 1993. Inhibitors of aspartyl proteinases. Med. Res. Rev. 13:731-78
-
(1993)
Med. Res. Rev.
, vol.13
, pp. 731-778
-
-
Abdel-Meguid, S.S.1
-
47
-
-
0027219220
-
In vitro isolation and identification of human immunodeficiency virus (HIV) variants with reduced sensitivity to C-2 symmetrical inhibitors of HIV type 1 protease
-
Otto MJ, Garber S, Winslow DL, Reid CD, Aldrich P, et al. 1993. In vitro isolation and identification of human immunodeficiency virus (HIV) variants with reduced sensitivity to C-2 symmetrical inhibitors of HIV type 1 protease. Proc. Natl. Acad. Sci. USA 90:7543-47
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 7543-7547
-
-
Otto, M.J.1
Garber, S.2
Winslow, D.L.3
Reid, C.D.4
Aldrich, P.5
-
48
-
-
0028286025
-
Selection of multiple human immunodeficiency virus type 1 variants that encode viral proteases with decreased sensitivity to an inhibitor of the viral protease. Proc
-
Kaplan AH, Michael SF, Wehbie RS, Knigge MF, Paul DA, et al. 1994. Selection of multiple human immunodeficiency virus type 1 variants that encode viral proteases with decreased sensitivity to an inhibitor of the viral protease. Proc. Natl. Acad. Sci. USA 91:5597-601
-
(1994)
Natl. Acad. Sci. USA
, vol.91
, pp. 5597-5601
-
-
Kaplan, A.H.1
Michael, S.F.2
Wehbie, R.S.3
Knigge, M.F.4
Paul, D.A.5
-
49
-
-
0028014288
-
Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor
-
Ho DD, Toyoshima T, Mo H, Kempf DJ, Norbeck D, et al. 1994. Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor. J. Virol. 68:2016-20
-
(1994)
J. Virol.
, vol.68
, pp. 2016-2020
-
-
Ho, D.D.1
Toyoshima, T.2
Mo, H.3
Kempf, D.J.4
Norbeck, D.5
-
50
-
-
0028013171
-
Generation and characterization of a human immunodeficiency virus type 1 (HIV-1) mutant resistant to an HIV-1 protease inhibitor
-
El-Farrash MA, Kuroda MJ, Kitazaki T, Masuda T, Kato K, et al. 1994. Generation and characterization of a human immunodeficiency virus type 1 (HIV-1) mutant resistant to an HIV-1 protease inhibitor. J. Virol. 68:233-39
-
(1994)
J. Virol.
, vol.68
, pp. 233-239
-
-
El-Farrash, M.A.1
Kuroda, M.J.2
Kitazaki, T.3
Masuda, T.4
Kato, K.5
-
51
-
-
10544254087
-
In vitro induction of HIV-1 with reduced sensitivity to HIV protease inhibitors, KNI-227 and KNI-272
-
Yokohama, Jpn. Abstr.
-
Anderson B, Kageyama S, Ueno T, Mitsuya H. 1994. In vitro induction of HIV-1 with reduced sensitivity to HIV protease inhibitors, KNI-227 and KNI-272. 10th Int. Conf. AIDS STD, Yokohama, Jpn. p. 516B (Abstr.)
-
(1994)
10th Int. Conf. AIDS STD
-
-
Anderson, B.1
Kageyama, S.2
Ueno, T.3
Mitsuya, H.4
-
52
-
-
0028854676
-
Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor
-
Markowitz M, Mo H, Kempf DJ, Norbeck DW, Bhat TN, et al. 1995. Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor. J. Virol. 69: 701-6
-
(1995)
J. Virol.
, vol.69
, pp. 701-706
-
-
Markowitz, M.1
Mo, H.2
Kempf, D.J.3
Norbeck, D.W.4
Bhat, T.N.5
-
53
-
-
0028843163
-
Characterization of human immunodeficiency virus type 1 mutants with decreased sensitivity to proteinase inhibitor Ro 31-8959
-
Jacobsen H, Yasargil K, Winslow DL, Craig JC, Krohn A, et al. 1995. Characterization of human immunodeficiency virus type 1 mutants with decreased sensitivity to proteinase inhibitor Ro 31-8959. Virology 206:527-34
-
(1995)
Virology
, vol.206
, pp. 527-534
-
-
Jacobsen, H.1
Yasargil, K.2
Winslow, D.L.3
Craig, J.C.4
Krohn, A.5
-
54
-
-
0028949246
-
Characterization of a human immunodeficiency virus type 1 variant with reduced sensitivity to an aminodiol protease inhibitor
-
Patick AK, Rose R, Greytok J, Bechtold CM, Hermsmeier MA, et al. 1995. Characterization of a human immunodeficiency virus type 1 variant with reduced sensitivity to an aminodiol protease inhibitor. J. Virol. 69:2148-52
-
(1995)
J. Virol.
, vol.69
, pp. 2148-2152
-
-
Patick, A.K.1
Rose, R.2
Greytok, J.3
Bechtold, C.M.4
Hermsmeier, M.A.5
-
55
-
-
9344255832
-
Protease inhibitors: Cross resistance and in vivo observations
-
Kauai, HI. London: MediTech Media Ltd. (Abstr.)
-
Emini E, Schleif WA, Graham DA, Deutsch P, Massari F, et al. 1994. Protease inhibitors: cross resistance and in vivo observations. Proc. 3rd Int. Workshop HIV Drug Resist., Kauai, HI. p. 15. London: MediTech Media Ltd. (Abstr.)
-
(1994)
Proc. 3rd Int. Workshop HIV Drug Resist.
, pp. 15
-
-
Emini, E.1
Schleif, W.A.2
Graham, D.A.3
Deutsch, P.4
Massari, F.5
-
56
-
-
0028943992
-
In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors
-
Condra JH, Schleif WA, Blahy OM, Gabryelski LJ, Graham DJ, et al. 1995. In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors. Nature 374:569-71
-
(1995)
Nature
, vol.374
, pp. 569-571
-
-
Condra, J.H.1
Schleif, W.A.2
Blahy, O.M.3
Gabryelski, L.J.4
Graham, D.J.5
-
57
-
-
0029644939
-
Structure of HIV-1 protease complexed with KNI-272, a tight-binding transition-state analog containing allophenylnorstatine
-
Baldwin ET, Bhat TN, Gulnik S, Liu B, Topol IT, et al. 1995. Structure of HIV-1 protease complexed with KNI-272, a tight-binding transition-state analog containing allophenylnorstatine. Structure 3:581-90
-
(1995)
Structure
, vol.3
, pp. 581-590
-
-
Baldwin, E.T.1
Bhat, T.N.2
Gulnik, S.3
Liu, B.4
Topol, I.T.5
-
58
-
-
0028945211
-
Structural basis of drug resistance for the V82A mutant of HIV-1 protease: Backbone flexibility and subsite repacking
-
Baldwin ET, Bhat TN, Liu B, Pattabiraman N, Erickson J. 1995. Structural basis of drug resistance for the V82A mutant of HIV-1 protease: backbone flexibility and subsite repacking. Nat. Struct. Biol. 2:244-49
-
(1995)
Nat. Struct. Biol.
, vol.2
, pp. 244-249
-
-
Baldwin, E.T.1
Bhat, T.N.2
Liu, B.3
Pattabiraman, N.4
Erickson, J.5
-
59
-
-
0026793703
-
Kynostatin (KNI)-227 and -272, highly potent anti-HIV agents: Conformationally-constrained tripeptide inhibitors of HIV protease containing allophenylnorstatine
-
Mimoto T, Imai J, Kisanuki S, Enomoto H, Hattori N, et al. 1992. Kynostatin (KNI)-227 and -272, highly potent anti-HIV agents: conformationally-constrained tripeptide inhibitors of HIV protease containing allophenylnorstatine. Chem. Pharm. Bull. 40:2251-53
-
(1992)
Chem. Pharm. Bull.
, vol.40
, pp. 2251-2253
-
-
Mimoto, T.1
Imai, J.2
Kisanuki, S.3
Enomoto, H.4
Hattori, N.5
-
60
-
-
0027474739
-
In vitro anti-human immunodeficiency virus (HIV) activities of transition state mimetic HIV protease inhibitors containing allophenylnorstatine
-
Kageyama S, Mimoto T, Murakawa Y, Nomizu M, Ford H Jr, et al. 1993. In vitro anti-human immunodeficiency virus (HIV) activities of transition state mimetic HIV protease inhibitors containing allophenylnorstatine. Antimicrob. Agents Chemother. 37:810-17
-
(1993)
Antimicrob. Agents Chemother.
, vol.37
, pp. 810-817
-
-
Kageyama, S.1
Mimoto, T.2
Murakawa, Y.3
Nomizu, M.4
Ford Jr., H.5
-
61
-
-
0028231995
-
Protein binding of human immunodeficiency virus protease inhibitor KNI-272 and alteration of us in vitro antiretroviral activity in the presence of high concentrations of proteins
-
Kageyama S, Anderson BD, Hoesterey BL, Hayashi H, Kiso Y, et al. 1994. Protein binding of human immunodeficiency virus protease inhibitor KNI-272 and alteration of us in vitro antiretroviral activity in the presence of high concentrations of proteins. Antimicrob. Agents Chemother. 38:1107-11
-
(1994)
Antimicrob. Agents Chemother.
, vol.38
, pp. 1107-1111
-
-
Kageyama, S.1
Anderson, B.D.2
Hoesterey, B.L.3
Hayashi, H.4
Kiso, Y.5
-
62
-
-
0029151345
-
Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure
-
Gulnik SV, Suvorov LI, Liu B, Yu B, Anderson BA, et al. 1995 Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure. Biochemistry 34:9282-87
-
(1995)
Biochemistry
, vol.34
, pp. 9282-9287
-
-
Gulnik, S.V.1
Suvorov, L.I.2
Liu, B.3
Yu, B.4
Anderson, B.A.5
-
63
-
-
9344232533
-
Structures of cyclic ureas complexed with native and V82I mutant HIV-1 protease
-
Yokohama, Jpn. Abstr.
-
Chang C-H, DeLoskey RL, Lam P, Schadt M, Duke J, Weber PC. 1994. Structures of cyclic ureas complexed with native and V82I mutant HIV-1 protease. 10th Int. Conf. AIDS STD, Yokohama, Jpn. p. 110A (Abstr.)
-
(1994)
10th Int. Conf. AIDS STD
-
-
Chang, C.-H.1
DeLoskey, R.L.2
Lam, P.3
Schadt, M.4
Duke, J.5
Weber, P.C.6
-
64
-
-
34250080241
-
Design and structure of symmetry-based inhibitors of HIV-1 protease
-
Erickson JW. 1993. Design and structure of symmetry-based inhibitors of HIV-1 protease. Perspect. Drug Dis. Des. 1:109-28
-
(1993)
Perspect. Drug Dis. Des.
, vol.1
, pp. 109-128
-
-
Erickson, J.W.1
-
65
-
-
0028927329
-
Effect of point mutations on the kinetics and the inhibition of human immunodeficiency virus type 1 protease: Relationship to drug resistance
-
Lin Y, Lin X, Hong L, Foundling S, Heinrikson RL, et al. 1995. Effect of point mutations on the kinetics and the inhibition of human immunodeficiency virus type 1 protease: relationship to drug resistance. Biochemistry 34:1143-52
-
(1995)
Biochemistry
, vol.34
, pp. 1143-1152
-
-
Lin, Y.1
Lin, X.2
Hong, L.3
Foundling, S.4
Heinrikson, R.L.5
-
66
-
-
9344233097
-
Protease inhibitor resistant HIV-1 variants containing an altered protease cleavage site
-
Washington, DC. Abstr.
-
Doyon L, Poulin F, Pilote L, Clouette C, Thibeault D, et al. 1995. Protease inhibitor resistant HIV-1 variants containing an altered protease cleavage site. 2nd Natl. Conf. Hum. Retroviruses Related Infect., Washington, DC. p. 465 (Abstr.)
-
(1995)
2nd Natl. Conf. Hum. Retroviruses Related Infect.
, pp. 465
-
-
Doyon, L.1
Poulin, F.2
Pilote, L.3
Clouette, C.4
Thibeault, D.5
-
67
-
-
84921139972
-
Molecular characterization of HIV-1 variants resistant to specific viral protease inhibitors
-
Kauai, HI. London: Medi-Tech Media Ltd. (Abstr.)
-
Lamarre D, Croteau G, Pilote L, Rousseau P, Doyon L. 1994. Molecular characterization of HIV-1 variants resistant to specific viral protease inhibitors. Proc. 3rd Int. Workshop HIV Drug Resist., Kauai, HI. p. 10. London: Medi-Tech Media Ltd. (Abstr.)
-
(1994)
Proc. 3rd Int. Workshop HIV Drug Resist.
, pp. 10
-
-
Lamarre, D.1
Croteau, G.2
Pilote, L.3
Rousseau, P.4
Doyon, L.5
-
68
-
-
0028302946
-
Human immunodeficiency virus type 1 protease inhibitors: Evaluation of resistance engendered by amino acid substitutions in the enzyme's substrate binding site
-
Sardana VV, Schlabach AJ, Graham P, Bush BL, Condra JH, et al. 1994. Human immunodeficiency virus type 1 protease inhibitors: evaluation of resistance engendered by amino acid substitutions in the enzyme's substrate binding site. Biochemistry 33:2004-10
-
(1994)
Biochemistry
, vol.33
, pp. 2004-2010
-
-
Sardana, V.V.1
Schlabach, A.J.2
Graham, P.3
Bush, B.L.4
Condra, J.H.5
-
69
-
-
0028271687
-
Structure of the binding site for non-nucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1
-
Smerdon SJ, Jager J, Wang J, Kohlstaedt LA, Chinno AJ, et al. 1994. Structure of the binding site for non-nucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA 91:3911-15
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 3911-3915
-
-
Smerdon, S.J.1
Jager, J.2
Wang, J.3
Kohlstaedt, L.A.4
Chinno, A.J.5
-
70
-
-
0026755210
-
Biochemical studies on the reverse transcriptase and RNase H activities from HIV strains resistant to 3′-azido-3′ deoxythmidine
-
Lacey SF, Reardon JE, Furfine ES, Kunkel TA, Bebenek K, et al. 1992. Biochemical studies on the reverse transcriptase and RNase H activities from HIV strains resistant to 3′-azido-3′ deoxythmidine. J. Biol. Chem. 267:15789-94
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 15789-15794
-
-
Lacey, S.F.1
Reardon, J.E.2
Furfine, E.S.3
Kunkel, T.A.4
Bebenek, K.5
-
71
-
-
0025828608
-
Resistance of viruses to antiviral drugs
-
Freifeld AG, Ostrove JM. 1991. Resistance of viruses to antiviral drugs. Annu. Rev. Med. 42:247-59
-
(1991)
Annu. Rev. Med.
, vol.42
, pp. 247-259
-
-
Freifeld, A.G.1
Ostrove, J.M.2
-
73
-
-
0028030993
-
Ganciclovir resistance of cytomegalovirus: Mechanisms and prospects for rapid detection
-
Biron K. 1995. Ganciclovir resistance of cytomegalovirus: mechanisms and prospects for rapid detection. Int. Antivir. News 2:117-18
-
(1995)
Int. Antivir. News
, vol.2
, pp. 117-118
-
-
Biron, K.1
|