Controlled release systems for insulin delivery

Expert Opinion on Therapeutic Patents

Volumn 15, Issue 9, 2005, Pages 1147-1155

  Chu, Liang Yin ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Controlled delivery; Controlled release; Diabetes mellitus; Glucose responsive delivery; Injectable delivery; Insulin; Oral delivery; Pulmonary delivery; Transdermal delivery

Indexed keywords

CARBOXYMETHYLCELLULOSE; CHITOSAN; CONCANAVALIN A; COPOLYMER; CYSTEINE CONJUGATE; DIMETHYL SULFONE; ETHYLENE GLYCOL; HYALURONIC ACID; HYDROXYPROPYLCELLULOSE; INSULIN; INSULIN DERIVATIVE; OVOMUCOID; PALMITIC ACID ISOPROPYL ESTER; PHOSPHATIDYLCHOLINE; POLYCARBOPHIL; POLYGLACTIN; POLYMER; POLYMETHACRYLIC ACID; RECOMBINANT HUMAN INSULIN; STREPTOZOCIN;

CONTROLLED RELEASE FORMULATION; DIABETES MELLITUS; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; HUMAN; HYDROGEL; HYPERINSULINEMIA; IMPLANT; INJECTION SITE REACTION; INSULIN PUMP; INSULIN RELEASE; MICROCAPSULE; MICROEMULSION; MORTALITY; NONHUMAN; PATENT; PATIENT COMPLIANCE; REVIEW; SUSTAINED RELEASE FORMULATION; SYSTEMATIC REVIEW; TABLET FORMULATION;

EID: 25444431779     PISSN: 13543776     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543776.15.9.1147     Document Type: Review

References (101)

1. CHOI S, KIM SW: Controlled release of insulin from injectable biodegradable triblock copolymer depot in ZDF rats. Pharm. Res. (2003) 20(12):2008-2010.
2. TRAITEL T, COHEN Y, KOST J: Characterization of glucose-sensitive insulin release systems in simulated in vivo conditions. Biomaterials (2000) 21(16):1679-1687.
3. PEPPAS NA: Is there a future in glucose-sensitive, responsive insulin delivery systems? J. Drug Del. Sci. Tech. (2004) 14(4):247-256.
4. KIM YJ, CHOI S, KOH JJ et al.: Controlled release of insulin from injectable biodegradable triblock copolymer. Pharm. Res. (2001) 18(4):548-550.
5. TAKENAGA M, YAMAGUCHI Y, KITAGAWA A et al.: A novel sustained-release formulation of insulin with dramatic reduction in initial rapid release. J. Control. Release (2002) 79(1-3):81-91.
6. TAKENAGA M, YAMAGUCHI Y, KITAGAWA A et al.: Optimum formulation for sustained-release insulin. Int. J. Pharm. (2004) 271(1-2):85-94.
7. KAWAMORI R: Practical concept for insulin therapy. Intern. Med. (1994) 73:236-243.
8. MARSCHUTZ MK, CALICETI P, BERNKOP-SCHNURCH A: Design and in vivo evaluation of an oral delivery system for insulin. Pharm. Res. (2000) 17(12):1468-1474.
9. SURENDRAKUMAR K, MARTYN GP, HODGERS ECM et al.: Sustained release of insulin from sodium hyaluronate based dry powder formulations after pulmonary delivery to beagle dogs. J. Control. Release (2003) 91(3):385-394.
10. CALICETI P, VERONESE FM, LORA S: Polyphosphazene microspheres for insulin delivery: Int. J. Pharm. (2000) 211(1-2):57-65.
11. YE Q, ASHERMAN J, STEVENSON M et al.: DepoFoam™ technology: a vehicle for controlled delivery of protein and peptide drugs. J. Control. Release (2000) 64(1-3):155-166.
12. REITHMEIER H, HERRMANN J, GOPFERICH A: Lipid microparticles as a parenteral controlled release device for peptides. J. Control. Release (2001) 73(2-3):339-350.
13. ZENTNER GM, RATHI R, SHIH C et al.: Biodegradable block copolymers for delivery of proteins and water-insoluble drugs. J. Control. Release (2001) 72(1-3):203-215.
14. SLAGER J, DOMB AJ: Stereocomplexes based on poly(lactic acid) and insulin: formulation and release studies. Biomaterials (2002) 23(22):4389-4396.
15. YAMAGUCHI Y, TAKENAGA M, KITAGAWA A et al.: Insulin-loaded biodegradable PLGA microcapsules: initial burst release controlled by hydrophilic additives. J. Control. Release (2002) 81(3):235-249.
16. SHENOY DB, D'SOUZA RJ, TIWARI SB et al.: Potential applications of polymeric microsphere suspension as subcutaneous depot for insulin. Drug Develop. Ind. Pharm. (2003) 29(5):555-563.
17. JIANG G, QIU W, DELUCA PP: Preparation and in vitrol in vivo evaluation of insulin-loaded poly(acryloyl-hydroxyethyl starch)-PLGA composite microspheres. Pharm. Res. (2003) 20(3):452-459.
18. KIM YJ, KIM SW: Controlled drug delivery from injectable biodegradable triblock copolymer. Polymer Gels Fund. Appl. Acs Symp. Series (2003) 833:300-311.
19. KWON YM, KIM SW: Biodegradable triblock copolymer microspheres based on thermosensitive sol-gel transition. Pharm. Res. (2004) 21(2):339-343.
20. HARI PR, CHANDY T, SHARMA CP: Chitosan/calcium-alginate beads for oral delivery of insulin. J. Appl. Polym. Sci. (1996) 59(11):1795-1801.
21. AGARWAL V, REDDY IK, KHAN MA: Polymethyacrylate based microparticulates of insulin for oral delivery: preparation and in vitro dissolution stability in the presence of enzyme inhibitors. Int. J. Pharm. (2001) 225(1-2):31-39.
22. VICTOR SP, SHARMA CP: Stimuli sensitive polymethacrylic acid microparticles (PMAA) - oral insulin delivery. J. Biomater. Appl. (2002) 17(2):125-134.
23. SARIRI R, GHANNADZADEH A: The use of polyglycol succinates for the microencapsulation of insulin. Iran. Polym. J. (2002) 11(1):47-55.
24. WANG K, HE ZM: Alginate-konjac glucomannan-chitosan beads as controlled release matrix. Int. J. Pharm. (2002) 244(1-2):117-126.
25. DORKOOSH FA, VERHOEF JC, AMBAGTS MHC et al.: Peroral delivery systems based on superporous hydrogel polymers: release characteristics for the peptide drugs buserelin, octreotide and insulin. Europ. J. Pharm. Sci. (2002) 15(5):433-439.
26. MORISHITA M, LOWMAN AM, TAKAYAMA K et al.: Elucidation of the mechanism of incorporation of insulin in controlled release systems based on complexation polymers. J. Control. Release (2002) 81(1-2):25-32.
27. TORRES D, RODRIGUEZ M, CUNA M: Microencapsulated lipid cores for site-specific delivery of corticosteroid and peptide drugs to the colonic region. STP Pharm. Sci. (2003) 13(1):49-56.
28. KRAULAND AH, GUGGI D, BERNKOP-SCHNURCH A: Oral insulin delivery: the potential of thiolated chitosan-insulin tablets on non-diabetic rats. J. Control. Release (2004) 95(3):547-555.
29. PEPPAS NA: Devices based on intelligent biopolymers for oral protein delivery. Int. J. Pharm. (2004) 277(1-2):11-17.
30. PARK SE, NHO YC, LIM YM et al.: Preparation of pH-sensitive poly(vinyl alcohol-g-methacrylic acid) and poly(vinyl alcohol-g-acrylic acid) hydrogels by γ ray irradiation and their insulin release behavior. J. Appl. Polym. Sci. (2004) 91(1):636-643.
31. PARK SE, NHO YC, KIM HI: Preparation of poly(polyethylene glycol methacrylateco-acrylic acid) hydrogels by radiation and their physical properties. Radiat. Phys. Chem. (2004) 69(3):221-227.
32. SKYLER JS, CEFALU WT, KOURIDES IA et al.: Efficacy of inhaled insulin in Type 1 diabetes mellitus: a randomised proof-of-concept study. Lancet (2001) 357:331-335.
33. CEFALU WT, ROSENSTOCK J, BINDRA S: Inhaled insulin: a novel route for insulin delivery. Expert Opin. Investig. Drugs (2002) 11(5):687-691.
34. FU J, FIEGEL J, KRAULAND E et al.: New polymeric carriers for controlled drug delivery following inhalation or injection. Biomaterials (2002) 23(22):4425-4433.
35. DAVIDSON IG, LANGNER EJ, PLOWMAN SV et al.: Release mechanism of insulin encapsulated in trehalose ester derivative microparticles delivered via inhalation. Int. J. Pharm. (2003) 254(2):211-222.
36. FIEGEL J, FU J, HANES J: Poly(ether-anhydride) dry powder aerosols for sustained drug delivery in the lungs. J. Control. Release (2004) 96(3):411-423.
37. YEO SH, ZRANG HY. Development of a novel sonophoresis micro-device. Biomed. Microdev. (2003) 5(3):201-206.
38. LANGER R: Drug delivery and targeting. Nature (1998) 392:5-10.
39. GALAEV IY, MATTIASSON B: 'Smart' polymers and what they could do in biotechnology and medicine. Trends Biotechnol. (1999) 17:335-340.
40. BROWNLEE M, CERAMI A: A glucose-controlled insulin delivery system: semisynthetic insulin bound to lectin. Science (1979) 206:1190-1191.
41. BROWNLEE M, CERAMI A: Glycosylated insulin complexed to concanavalin A. Biochemical basis for a closed-loop insulin delivery system. Diabetes (1983) 32:499-504.
42. JEONG SY, KIM SW, EENINK MJD et al.: Self-regulating insulin delivery systems. I. Synthesis and characterization of glycosylated insulin. J. Control. Release (1984) 1:57-66.
43. SATO S, JEONG SY, MCREA JC et al.: Self-regulating insulin delivery systems. II. In vitro studies. J. Control. Release (1984) 1:67-77.
44. JEONG SY, KIM SW, HOLEMBERG D et al.: Self-regulating insulin delivery systems. III. In vivo studies. J. Control. Release (1985) 2:143-152.
45. SATO S, JEONG SY, MCREA JC et al.: Glucose stimulated insulin delivery system. Pure Appl. Chem. (1984) 56:1323-1328.
46. KOST J, HORBETT TA, RATNER BD et al.: Glucose sensitive membranes containing glucose oxidase: activity, swelling and permeability studies. J. Biomed. Mater. Res. (1985) 19:1117-1133.
47. ALBIN G, HORBETT TA, RATNER BD: Glucose sensitive membranes for controlled delivery of insulin: insulin transport studies. J. Control. Release (1985) 2:153-164.
48. ALBIN G, HORBETT TA, MILLER NL et al.: Theoretical and experimental studies of glucose sensitive membranes. J. Control. Release (1987) 6:267-291.
49. ITO Y, CASOLARO M, KONO K et al.: An insulin-releasing system that is responsive to glucose. J. Control. Release (1989) 10:195-203.
50. SIEGEL RA, FIRESTONE BA: Mechanochemical approaches to self-regulating insulin pump design. J. Control. Release (1989) 11:181-192.
51. MAKINO M, MACK EJ, OKANO T et al.: A microcapsule self-regulating delivery system for insulin. J. Control. Release (1990) 12:235-239.
52. MAKINO K, MACK EJ, OKANO T et al.: Self-regulated delivery of insulin from microcapsules. Biomater. Artific. Cells Immobiliz. Biotechnol. (1991) 19(1):219-228.
53. KITANO S, KOYAMA Y, KATAOKA K et al.: A novel drug delivery system utilizing a glucose responsive polymer complex between poly(vinyl alcohol) and poly(N-vinyl-2-pyrrolidone) with a phenylboronic acid moiety. J. Control. Release (1992) 19(1-3):162-170.
54. CHUNG DJ, ITO Y, IMANISHI Y: Sythesis of glucose-sensitive insulin-releasing protein devices. Bull. Chem. Soc. Jpn. (1994) 67(5):1468-1471.
55. CARTIER S, HORBETT TA, RATNER BD: Glucose-sensitive membrane coated porous filters for control of hydraulic permeability and insulin delivery from a pressurized reservoir. J. Membrane Sci. (1995) 106(1-2):17-24.
56. IMANISHI Y, ITO Y. Glucose-sensitive insulin-releasing molecular systems. Pure Appl. Chem. (1995) 67(12):2015-2021.
57. GRONING R, WALZ C: Development of experimental insulin pumps with glucose-controlled release. Int. J. Pharm. (1995) 119(2):127-131.
58. SHIINO D, MURATA Y, KUBO A et al.: Amine containing phenylboronic acid gel for glucose-responsive insulin release under physiological pH. J. Control. Release (1995) 37(3):269-276.
59. OBAIDAT AA, PARK K: Characterization of glucose dependent gel-sol phase transition of the polymeric glucose-concanavalin A hydrogel system. Pharma. Res. (1996) 13(7):989-995.
60. BROWN LR, EDELMAN ER, FISCHELGHODSIAN F et al.: Characterization of glucose-mediated insulin release from implantable polymers. J. Pharm. Sci. (1996) 85(12):1341-1345.
61. GRONING R: Computer-controlled drug release from small-sized dosage forms. J. Control. Release (1997) 48(2-3):185-193.
62. LIU F, SONG SC, MIX D et al.: Glucose-induced release of glycosylpoly(ethylene glycol) insulin bound to a soluble conjugate of concanavalin A. Bioconjug. Chem. (1997) 8(5):664-672.
63. YUK SH, BAE YH: Phase-transition polymers for drug delivery. Crit. Rev. Ther. Drug Car. Sys. (1999) 16(4):385-423.
64. PODUAL K, DOYLE FJ, PEPPAS NA: Preparation and dynamic response of cationic copolymer hydrogels containing glucose oxidase. Polymer (2000) 41(11):3975-3983.
65. PODUAL K, DOYLE FJ, PEPPAS NA: Glucose-sensitivity of glucose oxidase-containing cationic copolymer hydrogels having poly(ethylene glycol) grafts. J. Control. Release (2000) 67(1):9-17.
66. PODUAL K, DOYLE FJ, PEPPAS NA: Dynamic behavior of glucose oxidase-containing microparticles of poly(ethylene glycol)-grafted cationic hydrogels in an environment of changing pH. Biomaterials (2000) 21(14):1439-1450.
67. DE WOLF FA, BRETT GM: Ligand-binding proteins: their potential for application in systems for controlled delivery and uptake of ligands. Pharm. Rev. (2000) 52(2):207-236.
68. QIU Y, PARK K: Environment-sensitive hydrogels for drug delivery. Adv. Drug Deliver. Rev. (2001) 53(3):321-339.
69. KOST J, LANGER R: Responsive polymeric delivery systems. Adv. Drug Deliver. Rev. (2001) 46(1-3):125-148.
70. ZHANG K, WU XY: Modulated insulin permeation across a glucose-sensitive polymeric composite membrane. J. Control. Release (2002) 80:169-178.
71. BRAHIM S, NARINESINGH D, GUISEPPI-ELIE A: Bio-smart hydrogels: co-joined molecular recognition and signal transduction in biosensor fabrication and drug delivery. Biosens. Bioelectron. (2002) 17(11-12):973-981.
72. SOPPIMATH KS, AMINABHAVI TM, DAVE AM et al.: Stimulus-responsive 'smart' hydrogels as novel drug delivery systems. Drug Develop. Ind. Pharm. (2002) 28(8):957-974.
73. KANG SI, BAE YH: A sulfonamide based glucose-responsive hydrogel with covalently immobilized glucose oxidase and catalase. J. Control. Release (2003) 86(1):115-121.
74. PODUAL K, DOYLE F, PEPPAS NA: Modeling of water transport in and release from glucose-sensitive swelling-controlled release systems based on poly(diethylaminoethyl methacrylate-g-ethylene glycol). Ind. Eng. Chem. Res. (2004) 43(23):7500-7512.
75. MATSUMOTO A, KURATA T, SHIINO D et al.: Swelling and shrinking kinetics of totally synthetic, glucose-responsive polymer gel bearing phenylborate derivative as a glucose-sensing moiety. Macromolecules (2004) 37(4):1502-1510.
76. CHU LY, LIANG YJ, CHEN WM et al.: Preparation of glucose-sensitive microcapsules with a porous membrane and functional gates. Colloid. Surf. B Biointerf. (2004) 37(1-2):9-14.
77. CHU LY, LI Y, ZHU JH et al.: Control of pore size and permeability of a glucose-responsive gating membrane for insulin delivery. J. Control. Release (2004) 97:43-53.
78. STEIL GM, PANTELEON AE, REBRIN K: Closed-loop insulin delivery - the path to physiological glucose control. Adv. Drug Deliver. Rev. (2004) 56:125-144.
79. KIM YH, BAE YH, KIM SW: pH/temperature-sensitive polymers for macromolecular drug loading and release. J. Control. Release (1994) 28:143-152.
80. YU H, GRAINGER DW: Modified release of hydrophilic, hydrophobic and peptide agents from ionized amphiphilic gel networks. J. Control. Release (1995) 34(2):117-127.
81. HARIHARAN D, PEPPAS NA: Characterization, dynamic swelling behaviour and solute transport in cationic networks with applications to the development of swelling-controlled release systems. Polymer (1996) 37(1):149-161.
82. KAGATANI S, SHINODA T, KONNO Y et al.: Electroresponsive pulsatile depot delivery of insulin from poly(dimethylaminopropylacrylamide) gel in rats. J. Pharm. Sci. (1997) 86(11):1273-1277.
83. GOLDBART R, KOST J: Calcium responsive bioerodible drug delivery system. Pharm. Res. (1999) 16(9):1483-1486.
84. PARK TG: Temperature modulated protein release from pH/temperarure-sensitive hydrogels. Biomaterials (1999) 20(6):517-521.
85. RAMKISSOON-GANORKAR C, LIU F, BAUDYS M et al.: Modulating insulin-release profile from pH thermosensitive polymeric beads through polymer molecular weight. J. Control. Release (1999) 59(3):287-298.
86. KWOK CS, MOURAD PD, CRUM LA et al.: Self-assembled molecular structures as ultrasonically-responsive barrier membranes for pulsatile drug delivery. J. Biomed. Mater. Res. (2001) 57(2):151-164.
87. TRAITEL T, KOST J, LAPIDOT SA: Modeling ionic hydrogels swelling: Characterization of the non-steady state. Biotechnol Bioeng. (2003) 84(1):20-28.
88. ZRANG K, WU XY. Temperature and pH-responsive polymeric composite membranes for controlled delivery of proteins and peptides. Biomaterials (2004) 25(22):5281-5291.
89. NHO YC, LIM YM, LEE YM: Preparation, properties and biological application of pH-sensitive poly(ethylene oxide) (PEO) hydrogels grafted with acrylic acid(AAc) using gamma-ray irradiation. Radiat. Phys. Chem. (2004) 71(1-2):239-242.
90. PANAYIOTOU M, FREITAG R: Synthesis and characterisation of stimuli-responsive poly(N,N′-diethylacrylamide) hydrogels. Polymer (2005) 46(3):615-621.
91. GOLOMB G, SHAKED I, HOFFMAN A: Intrauterine administration of peptide drugs for systemic effect. Adv. Drug Deliver. Rev. (1995) 17(2):179-190.
92. EDELMAN ER, BROWN L, LANGER R: Quantification of insulin release from implantable polymer-based delivery systems and augmentation of therapeutic effect with simultaneous release of somatostatin. J. Pharm. Sci. (1996) 85(12):1271-1275.
93. BARICHELLO JM, MORISHITA M, TAKAYAMA K et al.: Absorption of insulin from Pluronic F-127 gels following subcutaneous administration in rats. Int. J. Pharm. (1999) 184(2):189-198.
94. CARENZA M, CALICETI P, VERONESE FM et al.: Poly(acryloyl-L-proline methyl ester) hydrogels obtained by radiation polymerization for the controlled release of drugs. Radiat. Phys. Chem. (2000) 57(3-6):471-475.
95. CALICETI P, SALMASO S, LANTE A et al.: Controlled release of biomolecules from temperature-sensitive hydrogels prepared by radiation polymerization. J. Control. Release (2001) 75(1-2):173-181.
96. SERSHEN S, WEST J: Implantable, polymeric systems for modulated drug delivery. Adv. Drug Deliver. Rev. (2002) 54(9):1225-1235.
97. SURINI S, AKIYAMA H, MORISHITA M et al.: Polyion complex of chitosan and sodium hyaluronate as an implant device for insulin delivery. STP Pharm. Sci. (2003) 13(4):265-268.
98. SURINI S, AKIYAMA H, MORISHITA M et al.: Release phenomena of insulin from an implantable device composed of a polyion complex of chitosan and sodium hyaluronate. J. Control. Release (2003) 90(3):291-301.
99. BAJPAI AK, BHANU S: In vitro release dynamics of insulin from a loaded hydrophilic polymeric nerwork. J. Mater. Sci. Mater. Med. (2004) 15(1):43-54.
100. SONI V, SINGH R, SRINIVASAN R et al.: Pulsatile insulin delivery through the ocular route. Drug Deliv. (1998) 5(1):47-51.
101. BARICHELLO JM, MORISHITA M, TAKAYAMA K et al.: Enhanced rectal absorption of insulin-loaded Pluronic (R) F-127 gels containing unsaturated fatty acids. Int. J. Pharm. (1999) 183(2):125-132.