Is there a future in glucose-sensitive, responsive insulin delivery systems?

Journal of Drug Delivery Science and Technology

Volumn 14, Issue 4, 2004, Pages 247-256

  Peppas, N A ^a  

^a The University of Texas at Austin   (United States)

Author keywords

Biosensors; Diabetes; Glucose sensitive devices; Insulin release

Indexed keywords

GLUCOSE; GLUCOSE OXIDASE; INSULIN;

DEVICE; DIABETES MELLITUS; DRUG DELIVERY SYSTEM; DYNAMICS; HORMONE RESPONSE; HORMONE SENSITIVITY; HYDROGEL; INSULIN INFUSION; INSULIN RELEASE; INSULIN TREATMENT; REVIEW; STEADY STATE;

EID: 4344587649     PISSN: 11571489     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1773-2247(04)50045-x     Document Type: Review

References (90)

1. ASHCROFT F.M., ASHCROFT S.J H. - Insulin: Molecular Biology to Pathology. - Oxford, New York, 1992.
2. CURRY D.L., BENNETT L.L., GRODSKY G.M. - Dynamics of insulin secretion by perfused rat pancreas. - Endocrinology, 83, 572-583, 1968.
3. NOMURA M., SHICHIRI M., KAWAMORI R., YAMASAKI Y., IWAMA N., ABE H. - A mathematical insulin-secretion model and its validation in isolated rat pancreatic islets perfusion. - Comp. Biomed. Res., 17, 570-579, 1984.
4. PACINI G., COBELLI C. - Estimation of b-cell secretion and insulin hepatic extraction by the minimal modeling technique. - Comp. Methods Programs Biomed., 32, 241-248, 1990.
5. BERGMAN R., IDER Y., BOWDEN C., COBELLI C. - Quantitative estimation of insulin sensitivity. - Am. J. Physiol., 236, 667-677, 1979.
6. SORENSON J.T., COLTON C.K., HILLMAN R.S., SOELDNER J.S. - Use of a pharmacokinetic model of glucoe homeostasis for assessment of performance requirements for improved insulin therapy. - Diabetes Care, 5, 148-157, 1982.
7. OLLERTON R.L. - Application of optimal control theory to diabetes mellitus. - Int. J. Control, 50, 2503-2522, 1989.
8. FISHER M.E. - A semiclosed-loop algorithm for control of blood glucose levels in diabetes. - IEEE Trans. Biomed. Eng, 38, 57-61, 1991.
9. SORENSON J.T. - Ph.D. Thesis, Chemical Engineering, M.I.T., Cambridge, 1985.
10. PARKER R.S., DOYLE III F.J., PEPPAS N.A. - A model-based algorithm for blood glucose control for type I diabetes patients. - IEEE Eng. Med. Biol. Mag., 46, 148-157, 1999.
11. CHIN Y.L., CHOU J.C., SUN T.P., CHUNG W.Y., HSIUNG S.K. - A novel pH sensitive ISFET with on chip temperature sensing using CMOS standard process. - Sensors and Actuators, B: Chemical, 76, 582-593, 2001.
12. CINAR A. - GlucoSim: A web-Based Educational Simulation Package for Glucose-Insulin Levels in the Human Body. - http: //216.47.139.198/glucosim/ index.html, 2002.
13. GOUGH D.A., KREUTZ-DELGADO K., BREMER T.M. - Frequency characterization of blood glucose dynamics. - Annals of Biomedical Engr, 31, 91, 2003.
14. HAGLEITNER C., HIERLEMANN A., LANGE D., KUMMER A., KERNESS N., BRAND O., BALTES H. - Smart single-chip gas sensor microsystem. - Nature, 414, 293-296, 2001.
15. HAHN J., EDGAR T.F. - A gramian-based approach to non-linearity quantification and model classification. - IEC Research, 40, 5724, 2001.
16. HAHN J., EDGAR T.F. - An improved method for non-linear model reduction using balancing of empirical gramians. - Comp. Chem. Engng., 26, 1379, 2002.
17. LYNCH S.M., BEQUETTE B.W. - Model predictive control of blood glucose in type I diabetics using subcutaneous glucose measurements. - Proc. Amer. Cont. Conf., 4039, 2002.
18. LYNCH S.M., BEQUETTE B.W. - Estimation-based model predictive control of blood glucose in type I diabetics: a simulation study. - Proc. IEEE 27th Annual Northeast Bioengr. Conf., 79, 2001.
19. PARKER R.S., DOYLE III F.J., PEPPAS N.A. - The intravenous route to blood glucose control. - IEEE Engr. in Medicine and Biology, 20, 65-73, 2001.
20. PODUAL K., DOYLE III F.J., PEPPAS N.A. - Preparation and characterization of the dynamic response of cationic copolymer hydrogels containing glucose oxidase. - Polymer, 41, 3975-3983, 2000.
21. PODUAL K., DOYLE III F.J., PEPPAS N.A. - Glucose-sensitivity of glucose oxidase-containing cationic copolymer hydrogels having poly(ethylene glycol) grafts. - J. Controlled Release, 67, 9-17, 2000.
22. SELAM J.-L., CHARLES M. A. - Devices for insulin administration. - Diabetes Care, 13, 955-979, 1990.
23. KENNEDY F. P. - Recent developments in insulin delivery techniques: Current status and future potential. - Drugs, 42, 213-227, 1991.
24. BUCHWALD H., ROHDET. D., KERNSTINE K. - Insulin delivery by implanted pumps: a chronic treatment for diabetes. - Trans. Am. Soc. Artif. Intern. Organs, 35, 5-7, 1989.
25. BRENNAN J.R., GEBHART S.S.P., BLACKHARD W.G. - Pump-induced insulin aggregation: a problem with the Biostator. - Diabetes, 34, 353-359, 1985.
26. LACY P.E. - Treating diabetes with transplanted cells. - Scientific American, 275, 50-58, 1995.
27. HOFFMAN A. S. - Conventional and environment-sensitive hydrogels for medical and industrial uses: a review paper. - Polym. Preprints, 31 (1), 220-221, 1990.
28. KOST J., LANGER R. - Equilibrium swollen hydrogels in controlled release applications. - In: Hydrogels in Medicine and Pharmacy, N.A. Peppas Ed., CRC Press, Boca Raton, 1986, 3, 95-107.
29. PEPPAS N.A. - Other biomedical applications of hydrogels. - In: Hydrogels in Medicine and Pharmacy, N.A. Peppas Ed., CRC Press, Boca Raton, 1986, 3, 177-194.
30. RATNER B. - Biomedical applications of hydrogels: critical appraisal and review. - In: Biocompatibility of Clinical Implant Materials, D.F. Williams Ed., CRC Press, Boca Raton, 1981, 2, 145-153.
31. PEPPAS N.A., KORSM EYER R.W. - Dynamic swollen hydrogels in controlled release applications. - In: Hydrogels in Medicine and Pharmacy, N.A. Peppas Ed., CRC Press, Boca Raton, 1986, 3, 109-135.
32. LU L., MIKOS A.G. - Importance of new processing techniques in tissue engineering. - MRS Bull., 21, 28-32, 1996.
33. LANGER R., HSIEH D.S.T., RHINEW., FOLKMAN J. - Control of release kinetics of macromolecules from polymers. - J. Membr. Sci., 7, 330-350, 1980.
34. LANGER R. - Polymeric delivery systems for controlled drug release. - Chem. Eng. Comm., 6, 1, 1980.
35. FALAMARZlAN M., MOXLEY B.C., FIRESTONE B.A., SIEGEL R.A. - pH sensitive drug release from hydrophobic polyelectrolyte hydrogels. - Proceed. Intern. Control. Rel. Bioact. Mater., 15, 23, 1988.
36. KOPECEK J., KOPECKOVA P. - Targetable polymeric drugs. - Polym. Preprints, 31, 196-197, 1990.
37. BRANNON-PEPPAS L. - Novel vaginal drug release applications. - Adv. Drug Deliv. Revs., 11, 169-177, 1993.
38. MALLAPRAGADA S.K., PEPPAS N.A. - Dissolution mechanism of semicrystalline poly(vinyl alcohol) in water. - J. Polym. Sci. Part B - Polym. Phys., 34, 1339-1346, 1996.
39. MALLAPRAGADA S.K., PEPPAS N.A., COLOMBO P. - Modification of drug release profiles and swelling behavior of poly(vinyl alcohol) due to the presence of a crystalline phase. - Polym. Mater. Sci., Engin. Proceed., 74, 416-417, 1996.
40. KORSMEYER R.W., PEPPAS N.A. - Effect of the morphology of hydrophilic polymeric matrices on the diffusion and release of water soluble drugs. - J. Membr. Sci., 9, 211-227, 1981.
41. SIEGEL R.A., FIRESTONE B.A. - pH-Dependent equilibrium swelling properties of hydrophobic polyelectrolyte copolymer gels. - Macromolecules, 21, 3254-3259, 1988.
42. BELL C.L., PEPPAS N.A. - Swelling/syneresis phenomena in gel-forming interpolymer complexes. - J. Biomater. Sci., Polym. Ed., 7, 671-683, 1996.
43. FIRESTONE B.A., SIEGEL R.A. - Swelling equilibria and kinetics in pH-sensitive hydrophobic membranes. - Proceed. Intern. Control. Rel. Bioact. Mater., 14, 81-82, 1987.
44. FIRESTONE B.A., SIEGEL R.A. - Dynamic pH dependent swelling properties of a hydrophobic polyelectrolyte gel. - Polym. Comm., 29, 204-208, 1988.
45. SIEGEL R.A., FALAMARZlAN M., FIRESTONE B.A., MOXLEY B.C. - pH-controlled release from hydrophobic/polyelectrolyte copolymer hydrogels. - J. Contr. Release, 8, 179-182, 1988.
46. SIEGEL R.A., FIRESTONE B.A. - Buffer and ionic strength effects on swelling of polyelectrolyte hydrogels. - Proceed. Intern. Control. Rel. Bioact. Mater., 15, 24-25, 1988.
47. SIEGEL R.A., JOHANES I., FIRESTONE B.A. - Buffer effects on swelling kinetics of pH-sensitive gels. - Proceed. Intern. Control. Rel. Bioact. Mater., 16, 197-198, 1989.
48. FIRESTONE B.A., SIEGEL R.A. - Kinetics and mechanisms of water sorption in hydrophobic, ionizable copolymer gels. - J. Appl. Polym. Sci., 43, 901-914, 1991.
49. SIEGEL R.A., JOHANNES I., HUNT C.A., FIRESTONE B.A. - Buffer effects on swelling in polybasic gels. - Pharm. Res., 9 (1), 76-81, 1992.
50. CORNEJO-BRAVO J.M., SIEGEL R.A. - Water vapor sorption behavior of copolymers of N,N-diethylaminoethyl methacrylate and methyl methacrylate. - Biomaterials, 17 (12), 1187-1193, 1996.
51. HARIHARAN D., PEPPAS N.A. - Characterization, dynamic swelling behavior and solute transport in cationic networks with application to the development of swelling-controlled release systems. - Polymer, 37 (1), 149-158, 1996.
52. AM ENDE M.T., HARIHARAN D., PEPPAS N.A. - Factors influencing drug and protein transport and release from ionic hydrogels. - React. Polym., 25, 127-137, 1995.
53. SEMINOFF L., OLSEN G., ZHENG J., KIM S.W. - Self-regulated insulin release. - Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 15, 160-161, 1988.
54. MIYATA M., JIKIHARA A., NAKAMAE K., URAGAMI T., HOFFMAN A.S., KINOMURA K., OKUMURA M. - Preparation of glucose-sensitive hydrogels by entrapment or copolymerization of concanavalin A in a glycosyloxyethyl methacrylate hydrogel. - In: Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems, Ogata, N., Kim, S. W., Feijen, J. and Okano, T. Eds., Wiley, New York, 1996, pp. 237-240.
55. SHINO D., KATAOKA K., KOYAMA Y., YOKOHAMA M., OKANO T., SAKURAI Y. - A self-regulated insulin delivery system using boronic acid gel. - J. Intell. Mater. Struc., 5, 311-314, 1994.
56. SHINO D., MURATA Y., KUBO A., KATAOKA K., KOYAMA Y., KIKUCHI A., YOKOHAMA M., OKANOT., SAKURAI Y., OKANO T. - Amine containing phenylboronic acid gel for glucose-responsive insulin release under physiological pH. - J. Controlled Release, 37, 269-276, 1995.
57. ALBIN G., HORBETT T. A., RATNER B.D. - Glucose-sensitive membranes for controlled release of insulin. - In: Pulsed and Self-Regulated Drug Delivery, CRC Press, Boca Raton, 1990, pp. 160-185.
58. HELLER J. - Chemically self-regulated drug delivery systems. - J. Controlled Release, 8, 111-125, 1988.
59. HELLER J., CHANGE A.C., RODD G., GRODSKY G.M. - Release of insulin from pH-sensitive poly(ortho esters). - J. Controlled Release, 13, 295-302, 1990.
60. CHANDY T., SHARMA C.P. - Glucose-responsive insulin release from poly(vinyl alcohol)-blended polyacrylamide membranes containing glucose oxidase. - J. Appl. Polym. Sci., 46, 1159-1167, 1992.
61. ALBIN G., HORBETT T.A., RATNER B.D. - Glucose sensitive membranes for controlled delivery of insulin: insulin transport studies. - J. Controlled Release, 2, 153-164, 1985.
62. ALBIN G., HORBETT T.A., MILLER S.R., RICKER N.L. - Theoretical and experimental studies of glucose-sensitive membranes. - J. Controlled Release, 6, 267-291, 1987.
63. KLUMB L.A., HORBETT T.A. - Design of insulin delivery devices based on glucose sensitive membranes. - J. Controlled Release, 18, 59-80, 1992.
64. CARTIER S., HORBETT T.A., RATNER B.D. - Glucose-sensitive membrane coated porous filters for control of hydraulic permeability and insulin delivery from a pressurized reservoir. - J. Membr. Sci., 106, 17-24, 1995.
65. GOLDRAICH M., KOST J. - Glucose-sensitive polymeric matrices for controlled drug delivery. - Clin. Mater., 13, 135-142, 1993.
66. ISHIHARA K., KOBAYASHI M., ISHIMARU N., SHINOHARA I. - Glucose induced permeation control of insulin through a complex membrane consisting of immobilized glucose oxidase. - Polym. J., 16 (8), 625-631, 1984.
67. ISHIHARA K., MATSUI K. - Glucose-responsive insulin release from polymer capsule. - J. Polym. Sci. Polym. Lett. Ed., 24, 413-417, 1986.
68. ISHIHARA K., KOBAYASHI M., SHINOHARA I. - Insulin permeation through amphiphilic polymer membranes having 2-hydroxyethyl methacrylate moeity. - Polym. J., 16 (8), 647-651, 1984.
69. ITO Y., CASOLARO M., KONO K., IMANISHI Y. - An insulin releasing system which is responsive to glucose. - J. Controlled Release, 10, 195-203, 1989.
70. PODUAL K., DOYLE III F.J., PEPPAS N.A. - Dynamic behavior of glucose-oxidase-containing microparticles of poly(ethylene glycol)-grafted cationic hydrogels in an environment of changing pH. - Biomaterials, 21, 1439-1450, 2000.
71. LANGER R., PEPPAS N.A. - Advances in biomaterials, drug delivery, and bionanotechnology. - AIChE J., 49, 2990-3006, 2003.
72. FOSS A.C., GOTO T., MORISHITA M., PEPPAS N.A. - Development of Acrylic-Based Copolymers for Oral Insulin Delivery. - Europ. J. Pharm. Biopharmac., 57, 163-169, 2004.
73. PEPPAS N.A. - Kinetics of smart hydrogels. - In: Reflexive Polymers and Hydrogels: Understanding and Designing Fast-responsive Polymeric Systems, N. Yui, R. Mrsny and K. Park, Eds., CRC Press, Boca Raton, 2004, pp. 99-113.
74. MORISHITA M., GOTO T., PEPPAS N.A., JOSEPH J.I., TORJMAN M.C., MUNSICK C., NAKAMURA K., TAKAYAMA K., LOWMAN A.M. - Mucosal insulin delivery systems based on complexation polymer hydrogels: effect of particle size on insulin enteral absorption. - J. Controlled Release, 97, 115-124, 2004.
75. PEPPAS N.A. - Devices based on intelligent biopolymers for oral protein delivery. - Intern. J. Pharmac., 277, 11-17, 2004.
76. PODUAL K., DOYLE III F.J., PEPPAS N.A. - Glucose-sensitive cationic hydrogels: preparation characterization and modeling of swelling properties. - In: Biomaterials Carriers for Drug Delivery, and Scaffolds for Tissue Engineering, N.A. Peppas, D.J. Mooney, A.G. Mikos and L. Brannon-Peppas Eds., AIChE, New York, 1997, pp. 190-192.
77. PODUAL K., DOYLE III F.J., PEPPAS N.A. - Preparation and characterization of the dynamic response of cationic copolymer hydrogels containing glucose oxidase. - Polymer, 41,3975-3983, 2000.
78. PODUAL K., DOYLE III F.J., PEPPAS N.A. - Glucose-sensitivity of glucose oxidase-containing cationic copolymer hydrogels having poly(ethylene glycol) grafts. - J. Controlled Release, 67, 9-17, 2000.
79. PARKER R.S., RABINOVITCH K.L., DOYLE III F.J., PEPPAS N.A. - Control analysis of pancreas models for optimal insulin delivery. - In: Biomaterials Carriers for Drug Delivery, and Scaffolds for Tissue Engineering, N.A. Peppas, D.J. Mooney, A.G. Mikos and L. Brannon-Peppas Eds., AIChE, New York, 1997, pp. 319-321.
80. DOYLE III F.J., DORSKI C.M., HARTING J.E., PEPPAS N.A. - Control and modeling of drug delivery devices for treatment of diabetes. - Proc. Am. Cont. Conf., 776-780, 1995.
81. DORSKI C.M., DOYLE III F.J., PEPPAS N.A. - Glucose-responsive complexation hydrogels. - Polym. Preprints, 37(1), 475-476, 1996.
82. PODUAL K., PEPPAS N.A., DOYLE III F.J. - Insulin release from pH-sensitive cationic hydrogels. - Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 25, 56-57, 1998.
83. PODUAL K., DOYLE III F.J., PEPPAS N.A. - Dynamic behavior of glucose-oxidase-containing microparticles of poly(ethylene glycol)-grafted cationic hydrogels in an environment of changing pH. - Biomaterials, 21, 1439-1450, 2000.
84. SCHWARTE L.M., PEPPAS N.A. - Preparation and characterization of PEG-containing pH-sensitive, cationic hydrogels for drug delivery applications. - Polym. Prepr., 38 (2) 596-597, 1997.
85. PARKER R.S., DOYLE III F.J., PEPPAS N.A. - A model-based algorithm for blood glucose control in type I diabetic patients. - IEEE Trans. Biomed. Eng., 46, 148-157, 1999.
86. SCHWARTE L.M., PODUAL K., PEPPAS N.A. - Cationic hydrogels for controlled release of proteins and other macromolecules. - In: Tailored Polymeric Materials for Controlled Delivery Systems, I. McCulloch and S.W. Shalaby Eds., ACS Symposium Series, ACS, Washington, 1999, Vol. 709, pp. 56-66.
87. PARKER R.S., WARD J.H., DOYLE III F.J., PEPPAS N.A. - Robust control in diabetes using a physiological model. - AIChE J. 46, 2537-2549, 2000.
88. DORSKI C.M., DOYLE III F.J., PEPPAS N.A. - Preparation and characterization of glucose-sensitive P(MAA-g-EG) hydrogels. - Polym. Mater. Sci. Eng. Proceed., 76, 281-282, 1997.
89. HASSAN C.M., DOYLE III F.J., PEPPAS N.A. - Dynamic behavior of glucose-responsive poly(methacrylic acid-g-ethylene glycol) hydrogels. - Macromolecules, 30, 6166-6173, 1997.
90. SCHWARTE L.M., PEPPAS N.A. - Novel poly(ethylene glycol)-grafted cationic hydrogels: preparation, characterization and diffusive properties. - Polymer, 39, 6057-6066, 1998.