Temperature and pH-responsive polymeric composite membranes for controlled delivery of proteins and peptides

Biomaterials

Volumn 25, Issue 22, 2004, Pages 5281-5291

  Zhang, Kai ^a,b   Wu, Xiao Yu ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b Patheon Inc   (Canada)

Author keywords

Controlled drug release; Membrane; Nanoparticle; Peptide; Protein; Thermally responsive material

Indexed keywords

ESTERS; INSULIN; MATHEMATICAL MODELS; MORPHOLOGY; PARTICLE SIZE ANALYSIS; PH EFFECTS; POLYMERIC MEMBRANES; SCANNING ELECTRON MICROSCOPY; VITAMINS;

NANOPARTICLES; PERMEABILITY; POLYMERIC COMPOSITE MEMBRANES; THERMAL SENSITIVITY;

PROTEINS;

COPOLYMER; CYANOCOBALAMIN; INSULIN; LEUPRORELIN; LYSOZYME; METHACRYLIC ACID; MOMANY PEPTIDE; N BENZOYLTYROSINE ETHYL ESTER; N ISOPROPYLACRYLAMIDE METHACRYLIC ACID COPOLYMER; NANOPARTICLE; PEPTIDE; PEPTIDE DERIVATIVE; POLY(N ISOPROPYLACRYLAMIDE); PROTEIN; RECOMBINANT HUMAN INSULIN; UNCLASSIFIED DRUG;

ARTICLE; ARTIFICIAL MEMBRANE; COMPOSITE MATERIAL; CONTROLLED DRUG RELEASE; HYDROPHOBICITY; MEMBRANE PERMEABILITY; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; STIMULUS RESPONSE; TEMPERATURE DEPENDENCE;

ACRYLAMIDES; DRUG DELIVERY SYSTEMS; GELS; HYDROGEN-ION CONCENTRATION; INSULIN; LEUPROLIDE; MEMBRANES; MEMBRANES, ARTIFICIAL; MICROSCOPY, ELECTRON, SCANNING; MODELS, BIOLOGICAL; MURAMIDASE; PEPTIDES; PERMEABILITY; POLYMERS; POLYMETHACRYLIC ACIDS; PROTEINS; TEMPERATURE; TIME FACTORS; VITAMIN B 12;

EID: 1942446329     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2003.12.032     Document Type: Article

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