Oral insulin delivery: The potential of thiolated chitosan-insulin tablets on non-diabetic rats

Journal of Controlled Release

Volumn 95, Issue 3, 2004, Pages 547-555

  Krauland, Alexander H ^a   Guggi, Davide ^a   Bernkop Schnürch, Andreas ^b  

^a UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Enzyme inhibitor; Glutathione; Insulin; Mucoadhesion; Oral administration; Thiolated polymer

Indexed keywords

ENZYME INHIBITION; ENZYMES; LIVING SYSTEMS STUDIES; POLYSACCHARIDES;

CHITOSAN; PHARMACOLOGY;

INSULIN;

BOWMAN BIRK INHIBITOR; CHITOSAN; ELASTATINAL; ENZYME INHIBITOR; GLUTATHIONE; INSULIN; POLYMER; THIOL DERIVATIVE;

ADHESION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; COVALENT BOND; DIABETES MELLITUS; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG OXIDATION; DRUG SYNTHESIS; ENTERIC COATED TABLET; GLUCOSE BLOOD LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REDUCTION KINETICS; TABLET FORMULATION;

ADHESIVES; ADMINISTRATION, ORAL; ANIMALS; BLOOD GLUCOSE; CHITIN; CHITOSAN; DELAYED-ACTION PREPARATIONS; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; GLUTATHIONE; IMIDOESTERS; INSULIN; INSULIN INFUSION SYSTEMS; INTESTINAL MUCOSA; MUCUS; OLIGOPEPTIDES; RATS; SULFHYDRYL COMPOUNDS; SWINE; TABLETS; TECHNOLOGY, PHARMACEUTICAL; TRYPSIN INHIBITOR, BOWMAN-BIRK SOYBEAN;

EID: 1542509567     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2003.12.017     Document Type: Article

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