Poly (acryloyl-L-proline methyl ester) hydrogels obtained by radiation polymerization for the controlled release of drugs

Radiation Physics and Chemistry

Volumn 57, Issue 3-6, 2000, Pages 471-475

  Carenza, M ^a   Caliceti, P ^b   Veronese, F M ^b   Martellini, F ^c   Higa, O Z ^c   Yoshida, M ^d   Katakai, R ^e  

^a CNR   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c INSTITUTO DE PESQUISAS ENERGÉTICAS E NUCLEARES   (Brazil)

^d JAPAN ATOMIC ENERGY AGENCY   (Japan)

^e GUNMA UNIVERSITY   (Japan)

Author keywords

Controlled release; Insulin; Radiation polymerization; Thermosensitive hydrogel

Indexed keywords

CONTROLLED DRUG DELIVERY; CROSSLINKING; ESTERS; HYDROGELS; INSULIN; POLYMERIZATION; SHRINKAGE; SWELLING; THERMAL EFFECTS;

HYPERGLYCEMIC LEVEL; POLYACRYLOYL PROLINE METHYL ESTER; RADIATION POLYMERIZATION;

RADIATION CHEMISTRY;

INSULIN; POLY(ACRYLOYLPROLINE METHYL ESTER); POLYMER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; CONFERENCE PAPER; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; CROSS LINKING; DRUG RELEASE; GLUCOSE BLOOD LEVEL; HEAT SENSITIVITY; HYDROGEL; MALE; NONHUMAN; POLYMERIZATION; POROSITY; RAT; STREPTOZOCIN DIABETES; TEMPERATURE;

EID: 0034026504     PISSN: 0969806X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-806X(99)00417-X     Document Type: Conference Paper

References (13)

1. Albin G., Horbett T.A., Ratner B.D. Glucose sensitive membranes for controlled delivery of insulin: insulin transport studies. J. Controlled Release. 2:1985;153-164.
2. Albin G., Horbett T.A., Miller S.R., Ricker N.L. Theoretical and experimental studies of glucose sensitive membranes. J. Controlled Release. 6:1987;267-291.
3. 1H-NMR relaxometry. Radiat. Phys. Chem. 55:1999;209-218.
4. Hoffman A.S. "Intelligent" polymers in medicine and biotechnology. Macromol. Symp. 98:1995;645-664.
5. Kabanov V. Ya. Preparation of polymeric biomaterials with the aid of radiation-chemical methods. Russ. Chem. Rev. 67:1998;783-816.
6. Kaetsu I. Biomedical materials, devices and drug delivery systems by radiation techniques. Radiat. Phys. Chem. 47:1996;419-424.
7. Martellini F., Higa O.Z., Takacs E., Safranj A., Yoshida M., Katakai R., Carenza M. Thermally reversible gels based on acryloyl-L-proline methyl ester as drug delivery systems. Radiat. Phys. Chem. 55:1999;185-192.
8. Miyajima M., Yoshida M., Sato H., Omichi H., Katakai R., Higuchi W.I. Controlled release of 9-β-D-arabinofuranosyladenine from thermo-responsive devices based on acryloyl-L-proline methyl ester. Int. J. Pharm. 95:1993;153-160.
9. Okano T. Biorelated Polymers and Gels. 1998;Academic Press, San Diego.
10. Trehan A., Ali A. Recent approaches in insulin delivery. Drug Dev. Ind. Pharm. 24:1998;589-597.
11. Yoshida M., Asano M., Kumakura M., Katakai R., Mashimo T., Yuasa H., Yamanaka H. Thermo-responsive hydrogels based on acryloyl-L-proline methyl ester and their use as long-acting testosterone delivery systems. Drug Des. Delivery. 7:1991;159-174.
12. Yoshida M., Omichi H., Katakai R. Light-scattering study of temperature-responsive poly(acryloyl-L-proline methyl ester). Eur. Polym. J. 28:1992;1141-1145.
13. Yoshida M., Safranj A., Katakai R. Polymerization, self-bridging, and degradation of acryloyl- and methacryloyl-L-proline methyl esters induced by radiation and characteristics of gel swelling. Macromolecules. 29:1996;2321-2323.