Preparation of poly(polyethylene glycol methacrylate-co-acrylic acid) hydrogels by radiation and their physical properties

Radiation Physics and Chemistry

Volumn 69, Issue 3, 2004, Pages 221-227

  Park, Sung Eun ^a   Nho, Young Chang ^b   Kim, Hyung Il ^a  

^a Chungnam National University   (South Korea)

^b Korea Atomic Energy Research Institute   (South Korea)

Author keywords

Hydrogels; Insulin; Oral delivery; pH responsive; Radiation

Indexed keywords

ACRYLICS; COPOLYMERS; CROSSLINKING; GAMMA RAYS; GELS; INSULIN; IONIZATION; IRRADIATION; MONOMERS; PH EFFECTS; POLYETHYLENE GLYCOLS; POLYMETHYL METHACRYLATES; SWELLING;

COMONOMERS;

HYDROGELS;

ACRYLIC ACID; ACRYLIC ACID COPOLYMER; CARBOXYL GROUP; INSULIN; MACROGOL DERIVATIVE; MACROGOL METHACRYLATE; METHACRYLIC ACID DERIVATIVE; POLY(POLYETHYLENE GLYCOL METHACRYLATE CO ACRYLIC ACID); UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL COMPOSITION; CROSS LINKING; GAMMA IRRADIATION; HYDROGEL; IONIZATION; PH; PHYSICAL PARAMETERS; RADIATION DOSE; SIMULATION; STOMACH JUICE; TECHNIQUE;

EID: 0347285294     PISSN: 0969806X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-806X(03)00473-0     Document Type: Article

References (16)

1. Bhattacharya A. Radiation and industrial polymer. Prog. Polym. Sci. 25:2000;371.
2. Caliceti P., Salmaso S., Lante A., Yoshida M., Katakai R., Martellini F., Mei L.H.I., Carenza M. Controlled release of biomolecules from temperature-sensitive hydrogels prepared by radiation polymerization. J. Control. Release. 75:2001;173.
3. Dorkoosh F.A., Verhoef J.C., Ambagts M.H.C., Rafiee-Tehrani M., Borchard G., Junginger H.E. Peroral delivery systems based on superporous hydrogel polymer. release characteristics for the peptide drugs buserelin, octreotide and insulin Eur. J. Pharm. Sci. 15:2002;433.
4. Hoffman A.S. Intelligent Polymers. 1997;American Chemical Society, Washington, DC.
5. Hoffman A.S. Hydrogels for biomedical applications. Adv. Drug Deliv. Rev. 43:2002;3.
6. Jabbari E., Nozari S. Swelling behavior of acrylic acid hydrogels prepared by γ-radiation crosslinking of polyacrylic acid in aqueous solution. Eur. Polym. J. 36:2000;2685.
7. Lowman A.M., Peppas N.A. Analysis of the complexation/decomplexation phenomena in polyelectrolyte networks. Macromolecules. 30:1997;4959.
8. Lowman, A.M., Morishita, M., Kajita, M., Nagai, T., Peppas, N.A., 1999. Oral Delivery of Insulin using pH-responsive Complexation Gels, J. Pharm. Sci. 88, 933.
9. Patel V.R., Amiji M.M. Preparation and characterization of freeze-dried chitosan-poly(ethylene oxide)hydrogels for site-specific antibiotic delivery in the stomach. Pharm. Res. 13:1996;588.
10. Peppas N.A., Keys K.B., Torres-Lugo M., Lowman A.M. Poly(ethylene glycol)-containing hydrogels in drug delivery. J. Control. Release. 62:1999;81.
11. Qiu Y., Park K.N. Environmental-sensitive hydrogels for drug delivery. Adv. Drug Deliv. Rev. 53:2001;321.
12. Ravichandran P., Shantha K.L., Rao P.K. Preparation, swelling characteristics and evaluation of hydrogels for stomach specific drug delivery. Int. J. Pharm. 154:1997;89.
13. Risbud M.V., Hardikar A.A., Bhat S.V., Bhonde R.R. pH-sensitive freeze-dried chitosan-polyvinyl pyrrolidone hydrogels as controlled release system for antibiotic delivery. J. Control. Release. 68:2000;23.
14. Rosiak J.M., Ulanski P. Synthesis of hydrogels by irradiation of polymers in aqueous solution. Radiat. Phys. Chem. 55:1999;139.
15. Siegel R.A., Falamarzian M., Firestone B.A., Moxley B.C. pH-controlled release from hydrophobic/polyelectrolyte copolymer hydrogels. J. Control. Release. 8:1988;179.
16. Ulanski P., Kadlubowski S., Rosiak J.M. Synthesis of poly(acrylic acid) nanogels by preparative pulse radiolysis. Radiat. Phys. Chem. 63:2002;533.